Precipitation-hardened nickel-based superalloys have been widely used as high temperature structural materials in gas turbine engine applications for more than 50 years. Powder metallurgy (P/M) technology was introduced as an innovative manufacturing process to overcome severe segregation and poor workability of alloys with high alloying contents. The excellent mechanical properties of P/M superalloys also depend upon the characteristic microstructures, including grain size and size distribution of γ′ precipitates. Heat treatment is the most critical processing step that has ultimate influences on the microstructure, and hence, on the mechanical properties of the materials. The main objective of this research was to study the γ′ precipitation kinetics in various cooling circumstances and also study the strength response to the cooling history in two model alloys, Rne88DT and U720LI. The research is summarized below: ACKNOWLEDGMENTS The author wishes to express her sincere thanks to her advisor, Dr. Keh-Minn Chang, for his continuously support, encouragement, and guidance he provided in the years passed. She would like to thank her colleagues Dr. Xingbo Liu and Dr. Zhengdong Long for their constructive suggestion on thermodynamic calculation and modeling approaches. Miss Li Yang, Mr. Matthew Burris, Mr. Robert Coulter and Dr. Longzou Ma provided their assistance at different stages during the research. Their contributions are also highly appreciated. The author would like to give Drs. David U. Furrer and Ganshu Sheng great appreciation for their generous support and constructive advice. She also appreciates the support from Diane Schwegler-Berry, NIOSH, Morgantown, WV, with the scanning electron microscope (SEM) operations. A special thanks is extended to Dr. Wanhong Yang for his solid assistance on the thermodynamic simulation and year-round encouragement. Finally, the author would like to acknowledge all the committee members for their time in reviewing the proposal and the dissertation, and their comments on various topics. v TABLE OF CONTENT CHAPTER 1. INTRODUCTION.