Properties of the poly(vinyl alcohol)/chitosan blend and its effect on the culture of fibroblast in vitro

Chuang, Wei‐Ching; Young, Tai‐Horng; Yao, Chun‐Hsu; Chiu, Wen‐Yen

doi:10.1016/s0142-9612(99)00054-x

Cited by 259 publications

(152 citation statements)

References 10 publications

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“…In general the same amount of water had a greater plasticizing effect on HPMC 603 than not HPMC 615 being the decrease of HPMC 603 T g greater than that of HPMC 615. PVA 4-98 presents a dry T g much lower, in the order of 50°C [52,53].…”

Section: Water Content Effectmentioning

confidence: 96%

Thermo-physical characterization of Pharmacoat® 603, Pharmacoat® 615 and Mowiol® 4-98

Perfetti

Alphazan

Wildeboer

et al. 2011

J Therm Anal Calorim

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Hydroxypropyl methylcellulose (HPMC) and polyvinyl alcohol (PVA) are important polymers in pharmaceutical, food and other industries being largely used as encapsulation agents. The characterization of two reference grades of HPMC (Pharmacoat Ò 603 and Pharmacoat Ò 615) and one reference grade of PVA (Mowiol Ò 4-98), through X-ray diffraction (XRD) and thermogravimetry (TG) is described. Specific analyses were performed by means of dynamic vapour sorption analysis of water adsorption/ desorption from vapours at 10, 25, 40, 55 and 70°C. Guggenheim-Anderson-de Boer (GAB), Brunauer-EmmettTeller (BET), Park and n-layer BET models were successfully used to fit the experimental data. The glass transition temperature as function of water content was measured by means of differential scanning calorimetry (DSC). The experimental data were analysed according to Linear, Gordon-Taylor, Fox and Roos equations. XRD

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Section: Water Content Effectmentioning

confidence: 96%

Thermo-physical characterization of Pharmacoat® 603, Pharmacoat® 615 and Mowiol® 4-98

Perfetti

Alphazan

Wildeboer

et al. 2011

J Therm Anal Calorim

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“…In the tissue engineering field, the knowledge of cell/ biomaterial interactions is the key issue [16], being the knowledge of the material biocompatibility a fundamental parameter for successful membrane and scaffold development [17]. Cell culture techniques have been extensively used for the study of cell/biomaterial interactions allowing the investigation of the biomaterial cytotoxicity and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Osteoblast, fibroblast and in vivo biological response to poly(vinylidene fluoride) based composite materials

Costa

Ribeiro

Lopes

et al. 2012

J Mater Sci: Mater Med

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Electroactive materials can be taken to advantage for the development of sensors and actuators as well as for novel tissue engineering strategies. Composites based on poly(vinylidene fluoride), PVDF, have been evaluated with respect to their biological response. Cell viability and proliferation were performed in vitro both with Mesenchymal Stem Cells differentiated to osteoblasts and Human Fibroblast Foreskin 1. In vivo tests were also performed using 6-weekold C57Bl/6 mice. It was concluded that zeolite and clay composites are biocompatible materials promoting cell response and not showing in vivo pro-inflammatory effects which renders both of them attractive for biological applications and tissue engineering, opening interesting perspectives to development of scaffolds from these composites. Ferrite and silver nanoparticle composites decrease osteoblast cell viability and carbon nanotubes decrease fibroblast viability. Further, carbon nanotube composites result in a significant increase in local vascularization accompanied an increase of inflammatory markers after implantation.

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“…Hydrogels are known to exhibit good biocompatibility and are highly responsive to external media such as temperature, pH, electrical pulses, etc. (Candy and Sharma [ 7], Chuang et al [ 8], Kim et al [ 9] Yazdani and Retuert [10].…”

Section: Introductionmentioning

confidence: 99%

New oil modified acrylic polymer for pH sensitive drug release: Experimental results and statistical analysis

Panja

Chattopadhyay²

2015

JNS

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Abstract:We report results of an experimental study, complemented by detailed statistical analysis of the experimental data, on the development of a more effective control method of drug delivery using a pH sensitive acrylic polymer. New copolymers based on acrylic acid and fatty acid are constructed from dodecyl castor oil and a tercopolymer based on methyl methacrylate, acrylic acid and acryl amide were prepared using this new approach. Water swelling characteristics of fatty acid, acrylic acid copolymer and tercopolymer respectively in acid and alkali solutions have been studied by a stepchange method. The antibiotic drug cephalosporin and paracetamol have also been incorporated into the polymer blend through dissolution with the release of the antibiotic drug being evaluated in bacterial stain media and buffer solution. Our results show that the rate of release of paracetamol getss affected by the pH factor and also by the nature of polymer blend. Our experimental data have later been statistically analyzed to quantify the precise nature of polymer decay rates on the pH density of the relevant polymer solvents. The time evolution of the polymer decay rates indicate a marked transition from a linear to a strictly non-linear regime depending on the whether the chosen sample is a general copolymer (linear) or a tercopolymer (non-linear). Non-linear data extrapolation techniques have been used to make probabilistic predictions about the variation in weight percentages of retained polymers at all future times, thereby quantifying the degree of efficacy of the new method of drug delivery. Indexing Terms/Key words:

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Properties of the poly(vinyl alcohol)/chitosan blend and its effect on the culture of fibroblast in vitro

Cited by 259 publications

References 10 publications

Thermo-physical characterization of Pharmacoat® 603, Pharmacoat® 615 and Mowiol® 4-98

Thermo-physical characterization of Pharmacoat® 603, Pharmacoat® 615 and Mowiol® 4-98

Osteoblast, fibroblast and in vivo biological response to poly(vinylidene fluoride) based composite materials

New oil modified acrylic polymer for pH sensitive drug release: Experimental results and statistical analysis

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