Properties of Specialist Fibres and Bragg Gratings for Optical Fiber Sensors

Canning, John

doi:10.1155/2009/871580

Cited by 32 publications

(21 citation statements)

References 99 publications

(134 reference statements)

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“…To overcome the drawback of traditional biosensor which is usually time consuming, complicated, labeling required and hazardous, fiber optic sensing technology has been proposed by employing fiber Bragg gratings (FBGs), long period gratings (LPGs), and tilted fiber gratings (TFGs) with the advantages of label-free, real-time, multiplex and in-line determination (Wang and Wolfbeis, 2013;James and Tatam, 2003;Albert et al, 2013;Cusano et al, 2014;Zhou et al, 2004). However, the major challenge in fiber sensor field is the lack of sensitivity for applications with small biomolecules and low concentration of analyte (Fan and White, 2011;Canning, 2009). To improve the biosensing performance, techniques have been developed to accelerate the device sensitivity, for instance by cladding etching, side polishing and fiber tapering (Chen et al, 2005;Jang et al, 2009;Zhao et al, 2004;Ding et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Graphene oxide functionalized long period grating for ultrasensitive label-free immunosensing

Liu

Cai

et al. 2017

Biosensors and Bioelectronics

109

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We explore graphene oxide (GO) nanosheets functionalized dual-peak long period grating (dLPG) based biosensor for ultrasensitive label-free antibody-antigen immunosensing. The GO linking layer provides a remarkable analytical platform for bioaffinity binding interface due to its favorable combination of exceptionally high surface-to-volume ratio and excellent optical and biochemical properties. A new GO deposition technique based on chemical-bonding in conjunction with physical-adsorption was proposed to offer the advantages of a strong bonding between GO and fiber device surface and a homogeneous GO overlay with desirable stability, repeatability and durability. The surface morphology of GO overlay was characterized by Atomic force microscopy, Scanning electron microscope, and Raman spectroscopy. By depositing the GO with a thickness of 49.2 nm, the sensitivity in refractive index (RI) of dLPG was increased to 2538 nm/RIU, 200% that of non-coated dLPG, in low RI region (1.333-1.347) where bioassays and biological events were usually carried out. The IgG was covalently immobilized on GO-dLPG via EDC/NHS heterobifunctional cross-linking chemistry leaving the binding sites free for target analyte recognition. The performance of immunosensing was evaluated by monitoring the kinetic bioaffinity binding between IgG and specific anti-IgG in real-time. The GO-dLPG based biosensor demonstrates an ultrahigh sensitivity with limit of detection of 7 ng/mL, which is 10-fold better than non-coated dLPG biosensor and 100-fold greater than LPG-based immunosensor. Moreover, the reusability of GO-dLPG biosensor has been facilitated by a simple regeneration procedure based on stripping off bound anti-IgG treatment. The proposed ultrasensitive biosensor can be further adapted as biophotonic platform opening up the potential for food safety, environmental monitoring, clinical diagnostics and medical applications.

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Section: Introductionmentioning

confidence: 99%

Graphene oxide functionalized long period grating for ultrasensitive label-free immunosensing

Liu

Cai

et al. 2017

Biosensors and Bioelectronics

109

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“…LPGs or tilted FBGs (TFBGs) [35][36][37][38]. However, all proposed MMOF Bragg grating (MOFBG) sensors are using the large-hole MOF and thus not ideal for e.g.…”

Section: Microstructured Optical Fiber Bragg Grating Microfluidic Sensormentioning

confidence: 99%

Advances in optical fiber Bragg grating sensor technologies

et al. 2012

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Abstract:The authors review their recent advances in the development of optical fiber Bragg grating (FBG) sensor technologies. After a brief review of the fiber grating sensors, several newly developed FBG sensors are described. With the continuous development of fiber materials, microstructures and post-processing technologies, FBG sensors are still creative after the first demonstration of permanent gratings thirty years ago.

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“…Over the last decade, the biosensors based on optical fibers have attracted great attention and made rapid advances 1 . Fiber optic sensor can provide higher sensitivity and selectivity than the traditional sensors 2,3 .…”

Section: Introductionmentioning

confidence: 99%

Label-free oligonucleotide biosensor based on dual-peak long period fiber grating

Chen

Liu

Cardoso³

et al. 2016

SPIE Proceedings

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We report the simplification and development of biofunctionalization methodology based on one-step 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC)-mediated reaction. The dual-peak long period grating (dLPG) has been demonstrated its inherent ultrahigh sensitivity to refractive index (RI), achieving 50-fold improvement in RI sensitivity over a standard LPG sensor used in low RI range. With the simple and efficient immobilization of unmodified oligonucleotides on sensor surface, dLPG-based biosensor has been used to monitor the hybridization of complementary oligonucleotides showing a detectable oligonucleotide concentration of 4 nM with the advantages of label-free, real-time, and ultrahigh sensitivity.

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Properties of Specialist Fibres and Bragg Gratings for Optical Fiber Sensors

Cited by 32 publications

References 99 publications

Graphene oxide functionalized long period grating for ultrasensitive label-free immunosensing

Graphene oxide functionalized long period grating for ultrasensitive label-free immunosensing

Advances in optical fiber Bragg grating sensor technologies

Label-free oligonucleotide biosensor based on dual-peak long period fiber grating

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