Properties of POPC/POPE supported lipid bilayers modified with hydrophobic quantum dots on polyelectrolyte cushions

Kolasińska-Sojka, Marta; Wlodek, Magdalena; Szuwarzyński, Michał; Kereı̈che, Sami; Kováčik, Ľubomír; Warszyński, Piotr

doi:10.1016/j.colsurfb.2017.07.046

Cited by 4 publications

(6 citation statements)

References 41 publications

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“…The lipid bilayers self‐assemble into an energetically favorable structure with the hydrophilic headgroups exposed to the aqueous environment, sandwiching a bilayer of hydrophobic acyl chains, which offer a favorable environment for the encapsulation of hydrophobic molecules. This property has therefore been utilized to produce liposomes with lipid bilayers containing a variety of hydrophobic NPs (Figure a) . The conventional thin‐film hydration method is commonly used for the encapsulation of hydrophobic NPs within a lipid bilayer.…”

Section: Methods and Effects Of Incorporating Inorganic Nps Into Drugmentioning

confidence: 99%

“…This property has therefore been utilized to produce liposomes with lipid bilayers containing a variety of hydrophobic NPs (Figure 2a). [28,29] The conventional thin-film hydration method is commonly used for the encapsulation of hydrophobic NPs within a lipid bilayer. In this method, a mixture of lipids and hydrophobic NPs is dispersed in an organic solvent, which is evaporated to form a dry lipid film.…”

Section: Np Encapsulation Within the Lipid Bilayermentioning

confidence: 99%

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Stimuli‐Responsive Release of Antimicrobials Using Hybrid Inorganic Nanoparticle‐Associated Drug‐Delivery Systems

Moorcroft

Jayne

Evans

et al. 2018

Macromolecular Bioscience

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Recently, the combination of metallic nanoparticles (NPs) of Au, Ag, Fe2O3, and Fe3O4 with traditional soft matter drug‐delivery systems has emerged as a promising strategy to achieve site‐specific and controlled release of antimicrobial agents. By harnessing the plasmonic and magnetic properties of inorganic NPs, the disruption of antibiotic‐loaded liposomes, polymersomes, and hydrogels can be remotely triggered by mechanisms such as photo‐ and magneto‐thermal effects, microbubble cavitation, magnetic positioning, and pH‐changes, hence offering significant advantages in improving antibacterial efficacy, reducing side effects, and in overcoming antimicrobial resistance. This review highlights the latest development of stimuli‐responsive antibiotic delivery systems incorporating inorganic NPs. The methods employed for preparation of hybrid inorganic NP‐associated drug‐delivery systems and the effects this has upon the system are discussed. Finally, a detailed exposition of the NP‐mediated triggering mechanisms is provided and pertinent examples of their use in antimicrobial applications are presented.

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Section: Methods and Effects Of Incorporating Inorganic Nps Into Drugmentioning

confidence: 99%

Section: Np Encapsulation Within the Lipid Bilayermentioning

confidence: 99%

Stimuli‐Responsive Release of Antimicrobials Using Hybrid Inorganic Nanoparticle‐Associated Drug‐Delivery Systems

Moorcroft

Jayne

Evans

et al. 2018

Macromolecular Bioscience

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“…We have also observed this behaviour in the case of the formation of POPC/POPE supported lipid bilayer with hydrophobic quantum dots (QDs) on PLL terminated polyelectrolyte films. 63 In that case, the presence of QDs may be an important factor affecting the stability of liposomes. The final lipid layer structure on the PEM cushion was an interplay between the interactions of liposomes with the support and other interactions among lipid molecules within liposomes which are affected by the presence of QDs.…”

Section: Positively Terminated Multilayers Negatively Terminated Multmentioning

confidence: 99%

“…The final lipid layer structure on the PEM cushion was an interplay between the interactions of liposomes with the support and other interactions among lipid molecules within liposomes which are affected by the presence of QDs. 63…”

Section: Positively Terminated Multilayers Negatively Terminated Multmentioning

confidence: 99%

Interfacial and structural characteristics of polyelectrolyte multilayers used as cushions for supported lipid bilayers

et al. 2017

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The surface properties of polyelectrolyte multilayers (PEMs) obtained via sequential adsorption of oppositely charged polyions from their solutions and used as cushions for supported lipid bilayers were investigated. Five types of polyelectrolytes were used: cationic polyethyleneimine (PEI), poly(diallyldimethylammonium)chloride (PDADMAC), and poly-l-lysine hydrobromide (PLL); and anionic polysodium 4-styrenesulfonate (PSS) and poly-l-glutamic acid sodium (PGA). The wettability and surface free energy of the PEMs were determined by contact angle measurements using sessile drop analysis. Electrokinetic characterisation of the studied films was performed by streaming potential measurements of selected multilayers and the structure of the polyelectrolyte multilayer was characterized by synchrotron X-ray reflectometry. The examined physicochemical properties of the PEMs were correlated with the kinetics of the formation of supported lipid bilayers atop the PEM cushion.

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“…Another advantage of this method is the capacity and ease to incorporate functionalized additives (e.g. amphiphilic proteins [16], metal nanoparticles [17] or quantum dots [18,19]) to the membrane.…”

Section: Introductionmentioning

confidence: 99%

Structural evolution of supported lipid bilayers intercalated with quantum dots

Wlodek

Slastanova

Fox

et al. 2020

Journal of Colloid and Interface Science

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Properties of POPC/POPE supported lipid bilayers modified with hydrophobic quantum dots on polyelectrolyte cushions

Cited by 4 publications

References 41 publications

Stimuli‐Responsive Release of Antimicrobials Using Hybrid Inorganic Nanoparticle‐Associated Drug‐Delivery Systems

Stimuli‐Responsive Release of Antimicrobials Using Hybrid Inorganic Nanoparticle‐Associated Drug‐Delivery Systems

Interfacial and structural characteristics of polyelectrolyte multilayers used as cushions for supported lipid bilayers

Structural evolution of supported lipid bilayers intercalated with quantum dots

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