We study the extension of total variation (TV), total deformation (TD), and (second-order) total generalized variation (TGV 2 ) to symmetric tensor fields. We show that for a suitable choice of finite-dimensional norm, these variational seminorms are rotation-invariant in a sense natural and well suited for application to diffusion tensor imaging (DTI). Combined with a positive definiteness constraint, we employ these novel seminorms as regularizers in Rudin-Osher-Fatemi (ROF) type denoising of medical in vivo brain images. For the numerical realization, we employ the ChambollePock algorithm, for which we develop a novel duality-based stopping criterion which guarantees error bounds with respect to the functional values. Our findings indicate that TD and TGV 2 , both of which employ the symmetrized differential, provide improved results compared to other evaluated approaches.