Properties of Cordyceps Sinensis: A review

Chen, Peter Xin; Wang, Sunan; Nie, Shaoping; Marcone, Massimo F.

doi:10.1016/j.jff.2013.01.034

Cited by 120 publications

(72 citation statements)

References 53 publications

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“…Cordyceps sinensis, a Chinese caterpillar fungus, is known to be one of the most valuable and effective Chinese medicinal herbs, which possesses potential antioxidant, immunomodulatory, antitumor and anti-inflammatory properties (1). Paecilomyces hepiali, a parasitic fungus generally found in Cordyceps sinensis, contains similar chemical constituents and exhibits similar bioactivities (2).…”

Section: Introductionmentioning

confidence: 99%

Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract

Wang

Liu

et al. 2015

Molecular Medicine Reports

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Abstract. Paecilomyces hepiali, one of the most valuable and effective Chinese medicinal herbs, possesses potential antioxidant, immunomodulatory, antitumor and anti-inflammatory properties. The present study aimed to investigate the antifatigue and antihypoxic effects of Paecilomyces hepiali extract (PHC) in a mouse model. Using a rotating rod, forced swimming and running assessment, the antifatigue activity of PHC was determined. PHC administration for 7 days had no effect on mouse horizontal or vertical movement, indicating no neurotoxicity at the selected doses was observed. Using a normobaric hypoxia, sodium nitrite toxicosis and acute cerebral ischemia assessments, PHC was confirmed to possess antihypoxic effects. PHC treatment for 7 days significantly enhanced the serum and liver levels of adenosine triphosphate, superoxide dismutase and glutathione peroxidase, prior to and following 60 min of swimming. The levels of antioxidant-associated proteins in the livers of the mice were analyzed using western blotting. PHC effectively increased the expression levels of phosphorylated (p)-5'-monophosphate (AMP)-activated protein kinase (AMPK), p-protein kinase B (AKT) and p-mammalian target of rapamycin (mTOR). The results of the present study demonstrated that PHC efficiently enhanced endurance from fatigue and had antihypoxic effects through elevation of the antioxidant capacity in the serum and liver, at least in part through the AMPK and AKT/mTOR pathways. These results indicate the potential of this natural product as an antioxidant in the treatment of fatigue, hypoxia and their associated diseases.

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Section: Introductionmentioning

confidence: 99%

Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract

Wang

Liu

et al. 2015

Molecular Medicine Reports

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“…[7,8,12,14,15,24,39,48,52,66,67,83,92,98,107,121,136,140,161,162,167,173,177,178,180,188,194,200,207,208,[210][211][212]. [164].…”

Section: 배지 균사체 및 자실체 생산mentioning

confidence: 99%

Properties of the Silkworm (Bombyx mori) Dongchunghacho, a Newly Developed Korean Medicinal Insect-borne Mushroom: Mass-production and Pharmacological Actions

Lee¹,

Kim²,

Park³

et al. 2017

Journal of Life Science

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Cordyceps is a traditional Chinese medicinal herb well-known in China, Korea and Japan since B.C. 2,000. The original entomopathogenic fungus, Cordyceps sinensis belonging to the genus Cordyceps could not be found inside Korean peninsula due to the absence of the host insect for the corresponding entomogenous fungus. The development of artificial production methods of Korean type Cordyceps using the silkworm Bombyx mori as in vivo culture medium for the the entomopathogenic fungus Paecilomyces tenuipes is the first, and wonderful occasion in the research history of insect industry of this global world. The aim of this article is to review the historical research background, mass-production methods, and pharmacological effects of the silkworm-dongchunghacho (Paecilomyces tenuipes) which is a newly developed Korean medicinal insect-borne mushroom, and another non-insect-borne medicinal mushroom (Cordyceps militaris and Cordyceps pruinosa). Their biological actions include anti-tumor, immunostimulating, anti-fatigue, anti-stress, anti-oxidant, anti-aging, anti-diabetic, anti-inflammatory, anti-thrombosis, hypolipidaemic and insecticidal effects. The bioactive principles are protein-bound polysaccharides (hexose, hexosamin), cordycepin, D-manitol, acidic polysaccharide etc. Protein-bound polysaccharides and n-butanol fractions were demonstrated to show a significant anti-tumor activities but did not show a cytotoxicities. D-mannitol exhibited a significant prolongation of the life span in tumor bearing mice. Ergosterol did not show an efficient anti-tumor activity, but showed a significant phagocytosis enhancing activity. Anti-tumor activity of silkworm-dongchunghacho might be attributed to immuno-stimulating activities rather than cytotoxic effects [164]. Also this review comprises the breeding of Dongchunghacho varieties, optimization of culture conditions, improvement of learning and memory by Dongchunghacho, application of them as foods and chemical constituents.

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“…The cordyceps fungi are a group of parasitical macrofungi that mainly parasitize insects, other arthropods, and other fungi (Zhang et al 2012). Up to now, over 400 species of cordyceps fungi have been reported and most of them have been valuable traditional Chinese medicine and food for centuries (Chen et al 2013). All of the cordyceps fungi were originally assigned to the genus Cordyceps , family Clavicipitaceae (Kirk et al 2001).…”

Section: Macrofungi Parasitizing Animalsmentioning

confidence: 99%

Diversity, population genetics, and evolution of macrofungi associated with animals

Tang

Zhang

et al. 2015

Mycology

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Macrofungi refers to all fungi that produce visible fruiting bodies. These fungi are evolutionarily and ecologically very divergent. Evolutionarily, they belong to two main phyla, Ascomycota and Basidiomycota, and many of them have relatives that cannot form visible fruiting bodies. Ecologically, macrofungi can be associated with dead organic matter, plants, and animals. Here we review our current understanding of population structure and biogeography of macrofungi associated with animals. Their interactions, functions, and patterns of coevolution are described and discussed. Our focus is on studies using molecular markers. Our analyses suggest that the types of fungi–animal associations play an important role in the structure of these animal-associated fungal populations.

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Properties of Cordyceps Sinensis: A review

Cited by 120 publications

References 53 publications

Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract

Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract

Properties of the Silkworm (Bombyx mori) Dongchunghacho, a Newly Developed Korean Medicinal Insect-borne Mushroom: Mass-production and Pharmacological Actions

Diversity, population genetics, and evolution of macrofungi associated with animals

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