Properties of Avermectin Delivery System Using Surfactant-Modified Mesoporous Activated Carbon as a Carrier

Abstract

The sensitivity of avermectin to several environmental factors, especially light, causes low pesticidal activity and environmental pollution. In this study, surfactant-modified mesoporous activated carbon (MAC) was employed to absorb avermectin (Av) in order to improve its photostability and allow for sustained release of avermectin. The results suggest that sodium dodecyl sulfate (SDS) modified MAC has excellent absorption of avermectin, and the absorption can be represented by the Langmuir isotherm model. The Av-MAC-SDS delivery system significantly improves sustained release of avermectin and also effectively inhibits the photodegradation of avermectin. These results indicate that SDS-modified MAC can be used as a carrier for avermectin to improve its pesticidal activity and reduce pesticide residues.

Azobenzene-Avermectin B1a Derivatives for Optical Modulation of Insect Behaviors

“…23 These complicated molecules have attracted significant attention because of their high efficiency and low vertebrate toxicity. 24 Many derivatives modified at different positions were obtained by chemical manipulation or mutations. Some of them have been commercialized, such as ivermectin, emamectin, doramectin, eprinomectin, and selamectin.…”

“…Avermectins and other macrocyclic lactones are positive allosteric modulators of ligand-gated chloride channels, especially the glutamate-gated chloride channels (GluCls). , Avermectins are a complex of eight 16-membered ring lactones isolated from the fermentation broth of Streptomyces avermitilis with a broad spectrum of anthelmintic and insecticidal activities and widely used in veterinary medicine, agriculture, and human health, most notably as the miracle drug for onchocerciasis. − Among them, avermectin B1a is the most effective product against insects and mites . These complicated molecules have attracted significant attention because of their high efficiency and low vertebrate toxicity . Many derivatives modified at different positions were obtained by chemical manipulation or mutations.…”