Properties Evaluation of Gd2O3-DEG as New Contrast Agent Nanomagnetic Particles Comparing to Gd-DTPA in MRI

Abstract

Abstract-Magnetic resonance imaging (MRI) is widely used for imaging purposes. However, the sensitivity and intrinsic contrast of the MRI is low. In order to improve the quality of images Gd-DTPA (commercial Magnevist) is normally. Because of some limitations of low molecular weight of gadolinium chelates, nanoparticles gadolinium based contrast agents are proposed. In this study, we synthesized Gd-DTPA and compared its effects with Gd 2 O 3 -DEG nanoparticles. The samples were prepared at concentrations of 0.3, 0.6, 0.9 and 1.2 mM respectively by adding 1.5 ml deionized water. The corresponding Gd 2 O 3 -DEG nanoparticles diameter was measured about 80 nm. An in vitro study was performed using a 1.5 T scanner with standard spin echo protocol. Clearly, the signal amplitudes in both cases were increased with the Gd concentration at constant relaxation time. Also, a linear relation between signal intensity and longitudinal relaxation rate (R1) was observed with a correlation coefficient close to 1. The values of 4.30 and 14.27 (s -1 .mM -1 ) were achieved for Gd-DTPA and Gd 2 O 3 -DEG nanoparticles special relaxivity, respectively.