Properdin Levels in Infectious and Noninfectious Disease

Hinz, Carl F.

doi:10.1111/j.1749-6632.1956.tb40132.x

Cited by 45 publications

(9 citation statements)

References 3 publications

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“…Although properdin levels less than 1 unit per ml. have been reported in human disease, it has not been stated whether these levels altered the bactericidal power of the serum (13).…”

mentioning

confidence: 99%

A Study of the Relationship of the Normal Bactericidal Activity of Human Serum to Bacterial Infection*

Roantree¹,

Rantz²

1960

J. Clin. Invest.

191

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The potent heat-labile bactericidal property of fresh mammalian defibrinated blood or serum in vitro has been known since the studies of Nuttall (1) and Buchner (2) over 70 years ago. By 1928, it had been shown that serum components very like those of complement were necessary for this action (3). Although a number of investigators in the fields of bacteriology and immunology have interested themselves in this bactericidal power of fresh serum, little notice has been taken of it in clinical medicine, probably, as noted elsewhere (4), because it has been believed to be of doubtful effect in vivo.Interest has been revived in the bactericidal activity of serum by the work of Pillemer, Wardlaw and associates (5, 6). They described a normally occurring serum protein of large molecular weight which they named properdin. They attributed the bactericidal property of serum, in part at least, to the presence of properdin, which acted with the four components of complement in the presence of magnesium to kill the bacteria.The findings of Wardlaw and Pillemer (6) confirmed those of Mackie and Finkelstein (7) that the bacterial strains sensitive to the effect of serum are principally from species of gram-negative bacilli and that the degree of sensitivity is a characteristic of the strain rather than of the genus. However, whereas Wardlaw and Pillemer have described the action of the properdin system as being nonspecific and unrelated to antibody, Mackie and Finkelstein presented data showing that the absorption of a serum in the cold by a sensitive strain resulted in the removal of the killing effect only for that strain, leaving the effect

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“…Although properdin levels less than 1 unit per ml. have been reported in human disease, it has not been stated whether these levels altered the bactericidal power of the serum (13).…”

mentioning

confidence: 99%

A Study of the Relationship of the Normal Bactericidal Activity of Human Serum to Bacterial Infection*

Roantree¹,

Rantz²

1960

J. Clin. Invest.

191

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“…No consistent abnormalities in antibody formation, properdin levels or leukocyte phagocytosis have been demonstrated in patients with acute leukemia (6)(7)(8)(9)(10). Several experimental studies, however, have now demonstrated defects in the inflammatory cellular response of such patients.…”

Section: Methods Of Fillingmentioning

confidence: 95%

“…The age distribution of these patients was * Submitted for publication July 3, 1963;accepted November 8,1963.…”

Section: Methodsmentioning

confidence: 99%

Quantitative Studies of the Local Exudative Cellular Reaction in Acute Leukemia *

Perillie¹,

Finch²

1964

J. Clin. Invest.

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“…Admission laboratory work revealed Hb., 14 (Figure). H. influenzae, Type B, was also isolated from two blood cultures.…”

Section: Description Of Casesmentioning

confidence: 99%

Hemophilus Influenzae Infection in Adults

Kaplan¹

1958

AMA Arch Intern Med

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Properdin Levels in Infectious and Noninfectious Disease

Cited by 45 publications

References 3 publications

A Study of the Relationship of the Normal Bactericidal Activity of Human Serum to Bacterial Infection*

A Study of the Relationship of the Normal Bactericidal Activity of Human Serum to Bacterial Infection*

Quantitative Studies of the Local Exudative Cellular Reaction in Acute Leukemia *

Hemophilus Influenzae Infection in Adults

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