The recent water supply crisis in São Paulo showed the importance of regulation in the sanitation sector in the State of São Paulo. Therefore, this article aims to help in designing regulation by verifying the existence of economies of scale and of scope in the sanitation sector in São Paulo. For this, a database was constructed based on internal data from SABESP, together with operational data extracted from SNIS. The Evans and Heckman (1983) methodology was used with this database to evaluate economies of scale and of scope. The results enable us to conclude that the existence of diseconomies of scale is extremely rare in the cities served by SABESP.However, the evidence is weaker with relation to economies of scope. Nevertheless, in the vast majority of the cities served by SABESP, supplying water and sewerage services together within one company is cheaper than separating them between two companies focused on different services. In light of the results, we can conclude that initiatives that aim towards the structural separation of integrated water operators tend to generate inefficiencies on the production side, meaning supplying the services is less economical. These results are consistent with the international literature, which according to Abbott and Cohen (2009) indicates the existence of economies of scale up to a certain point, together with economies of scope in water and sewerage activities.