Propacetamol and ketoprofen after thyroidectomy

Abstract

In the immediate postoperative period after thyroid surgery performed using remifentanil, the concomitant use of propacetamol and ketoprofen does not improve analgesia compared with ketoprofen alone.

Analgesic efficacy and safety of nonsteroidal anti-inflammatory drugs after transurethral resection of prostate

“…Differences in pain scores were significant 6 hours after surgery. This result is in accordance with our knowledge on the analgesic properties of NSAIDs (13,14). The ideal postoperative analgesic treatment should provide rapid and effective pain relief, have a low incidence of adverse effects, and minimal impact on major organ systems.…”

“…The ideal postoperative analgesic treatment should provide rapid and effective pain relief, have a low incidence of adverse effects, and minimal impact on major organ systems. NSAIDs have been shown to be as potent as opioids in adults and in children for major surgery (13,15). Ehrlich et al reported that early aspirin initiation after lower urinary tract surgery does not appear to carry an increased risk of postoperative bleeding.…”

A Comparative Study of Effect of Intravenous Lidocaine Infusion, Gabapentin and Their Combination on Postoperative Analgesia after Thyroid Surgery

“…Although (NSAID) may be beneficial analgesics, many surgeons do not prefer them in thyroidectomy patients to limit the risk of postoperative bleeding [4] [5]. On the other hand, opioids have been associated with some adverse events as respiratory depression and frequent postoperative nausea and vomiting [6] [7].…”

Combined analgesics for postoperative pain therapy

“…Von den 25 analysierten Arbeiten verglichen insgesamt 23 Studien Paracetamol in unterschiedlichen Applikationsformen oder dessen "pro-drug" Propacetamol, das nach i.v.-Gabe zu 50% zu seiner aktiven Form Paracetamol metabolisiert wird, mit verschiedenen Nichtopioidanalgetika: Acht Studien mit Diclofenac [3,6,14,15,19,23,25,26], vier Studien mit Ketoprofen [1,2,12,14], zwei Studien mit Ibuprofen [8,44], eine mit Ibuprofen und dem COX-2-Hemmer Rofecoxib [30], drei weitere nur mit den COX-2-Hemmern Rofecoxib und Celecoxib [17,18,27], eine mit Suprofen [11], eine mit und ohne Ketorolac vs. Morphin [22], eine mit Fenoprofen [10], eine mit Tenoxicam [43] und eine mit ASS mit und ohne Koffein [32]. Je eine weitere Studie untersuchte ASS zusammen mit Mefenaminsäure [29] sowie Diclofenac mit Azapropazon [38].…”