A Comparative Study of Effect of Intravenous Lidocaine Infusion, Gabapentin and Their Combination on Postoperative Analgesia after Thyroid Surgery

Shal, Sahar El

doi:10.4236/ojanes.2017.79030

Cited by 5 publications

(13 citation statements)

References 47 publications

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“…Previous studies have found that intravenous infusion of lignocaine attenuates haemodynamic response associated with intubation and extubation of trachea ( 1 , 5 - 8 ). The combination of verapamil with lignocaine ( 7 ) and also drugs like diltiazem ( 6 ) have also found to attenuate haemodynamic response. Many previous studies show lignocaine infusion being used for postoperative pain relief ( 9 - 11 ).…”

Section: Discussionmentioning

confidence: 99%

“…Many drugs have been recommended for the attenuation of haemodynamic response during intubation and extubation of the trachea like remifentanil ( 1 ), lidocaine ( 2 ), magnesium sulfate ( 3 ), clonidine ( 4 ) esmolol ( 5 ), and dexmedetomidine ( 6 ). Recent studies have demonstrated that perioperative lignocaine infusion is also useful in reducing postoperative pain ( 7 - 10 ). Very few previous studies have demonstrated both the effect of lignocaine infusion that is attenuation of haemodynamic response to intubation and extubation of trachea and postoperative analgesia ( 11 - 13 ).…”

Section: Introductionmentioning

confidence: 99%

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Effect of Perioperative Intravenous Lignocaine Infusion on Haemodynamic Responses and postoperative Analgesia in Laparoscopic Cholecystectomy Surgeries

2018

Anesth Pain Med

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BackgroundDuring general anaesthesia, intubation of trachea and extubation of trachea are often associated with increase in haemodynamic response. Laparoscopic cholecystectomy is a minimal access surgery; postoperatively patients may experience moderate to severe pain. It is well known that lignocaine is useful in attenuating haemodynamic response to intubation and extubation. Previous studies also state that perioperative lignocaine infusion provides postoperative analgesia as well. We hypothesize that perioperative intravenous lignocaine infusion can both attenuate haemodynamic responses to intubation and extubation of trachea and also provide good postoperative analgesia in laparoscopic cholecystectomy surgeries.MethodsDouble blinded randomized controlled trial was undertaken at the department of anesthesia, Sri Siddartha medical college. In group A, 0.9% normal saline was used as placebo for perioperative intravenous infusion. In group B, preservative free 1.5 mg/kg 2 % lignocaine (Loxicard) diluted with normal saline to 1% given at 10 minutes to induction as bolus, followed by an infusion of 1.5 mg/kg/h. till 1 hour postoperatively.ResultsIn Group B there was a statistically less rise in heart rate [HR] and mean blood pressure [MBP] during intubation and extubation of trachea compared to group A. In group B there was a statistically significant increase in the mean pain free period postoperatively compared to group A.ConclusionsPerioperative intravenous infusion of lignocaine attenuates haemodynamic response during the intubation and extubation of the trachea. In addition, it also increases the mean pain free period postoperatively.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Perioperative Intravenous Lignocaine Infusion on Haemodynamic Responses and postoperative Analgesia in Laparoscopic Cholecystectomy Surgeries

2018

Anesth Pain Med

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“…Pain severity is subjective and highly variable, and it is important to ameliorate pain. The aim of postoperative pain control is to reduce the pain felt by the patient, and various studies have been performed for the reduction of post-thyroidectomy pain 2,10,15,16 .…”

Section: Discussionmentioning

confidence: 99%

“…Lidocaine has analgesic, antihyperalgesic, and anti-inflammatory properties and thus has many beneficial effects in many surgeries 7,8 . Several studies have shown that intravenous IV lidocaine use in the intraoperative period reduces postoperative pain [9][10][11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

Analgesic efficacy of Intraoperative lidocaine infusion in patients undergoing thyroidectomy

Akgul

Gözeler

Kars

et al. 2023

Rev. Assoc. Med. Bras.

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OBJECTIVE: A significant proportion of patients may experience moderate pain requiring treatment in the postoperative first 24 h following thyroidectomy. The aim of this study was to investigate the evaluation of postoperative patient-reported pain from intraoperative intravenous infusion of lidocaine in patients undergoing thyroidectomy surgery. METHODS: A total of 40 patients with American Society of Anesthesiologists physical status classifications I and II, aged 18-65 years, who were scheduled for elective thyroidectomy with the same indications under general anesthesia at the Ataturk University Medical Faculty's Ear, Nose, and Throat Clinic between November 2019 and February 2020, were divided into two equal groups as randomized and double-blind. Before induction of anesthesia, patients in the lidocaine group were given 1.5 mg/kg lidocaine IV bolus infusion during the operation and until the end of the first postoperative hour, followed by a continuous infusion of 1.5 mg/kg/h. Patients in the control group were given 0.9% isotonic solution according to the same protocol. In the postoperative period, 50 mg of dexketoprofen trometamol was administered and repeated every 12 h. Postoperative pain scores, additional analgesia, and side effects were recorded. RESULTS: Postoperative pain scores were significantly lower in the lidocaine group (n=20) compared to the control group (n=20) at 30 min and 1st, 2nd, 4th, 8th, and 12th h postoperatively (p < 0.05). Additional analgesia requirements were also significantly lower in the lidocaine group than in the control group (p<0.05). CONCLUSION: We recommended the use of intravenous lidocaine infusion intraoperatively in thyroidectomy surgery as it reduces pain scores.

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“…A sum of 11 RCTs [17][18][19][29][30][31][32][33][34][35][36] with 761 patients involved in the meta-analysis (381 in Lido group and 380 in Con group). Out of these RCTs, six studies were published in English [17][18][19][29][30][31] and ve in Chinese [32][33][34][35][36]. The year of publication ranged from 2014 to 2022; the main ASA status was I-II, and only one study involved patients ranked as ASA III [17].…”

Section: Study Characteristicsmentioning

confidence: 99%

Effects of Perioperative Lidocaine Infusion on Pain Management and Quality of Recovery Following Thyroid Surgery: A Systematic Review and Meta-analysis

Tang

et al. 2023

Preprint

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Background Thyroid surgery is often considered minor, and the postoperative pain is usually ignored. However, according to previous researches, the pain after thyroid surgery ranged from moderate to severe. Poorly controlled pain may lead to a series of adverse events, including dissatisfaction of patients, bad recovery, and extended hospital stay. Intravenous infusion of lidocaine has been proven to be effective in relieving pain after cholecystectomy, spinal surgery, and colorectal surgery. This meta-analysis was designed to explore the effects of lidocaine infusion on pain management and quality of recovery after thyroid surgery. Methods We conducted a comprehensive search of the Cochrane Library, PUBMED, Web of Science, EMBASE, China National Knowledge Infrastructure (CNKI), Wanfang, VIP, and China Biomedical Literature Database (CBM) from inception to September 12, 2022. Based on our previously established inclusion and exclusion criteria, eligible studies were involved. The primary outcomes were postsurgical pain scores and quality of recovery. The secondary outcomes included opioids consumption, hemodynamics variables, time to awareness and extubation, and adverse events. All analyses were performed using the random effects model with RevMan 5.4 software. We also evaluated the evidence quality of results by GRADEprofiler 3.6. Results A sum of 11 RCTs with 761 patients were involved. Compared to the controlled group, lidocaine reduced pain scores at 2h, 4h, 8h, and 12h after surgery, but not at 24h and 48h. Besides, lidocaine also facilitated recovery (mean difference [MD] = 7, 95% CI [4.78–9.25], P = 0.40, I2 = 0%), reduced opioids consumption during surgery (MD=-5.61, 95% CI [-7.90, -3.31], P = 0.97, I2 = 0%), and lowered the incidence of cough during extubation (RR = 0.41, 95% CI [0.30, 0.56], P = 0.34, I2 = 10%). No lidocaine-related adverse events was found in our meta-analysis. Conclusions Perioperative infusions of lidocaine could alleviate postoperative pain and facilitate recovery on the first day after surgery, without causing adverse events. Considering the high heterogeneity and relatively low quality of evidence among most of the results, further validation is reasonable.

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A Comparative Study of Effect of Intravenous Lidocaine Infusion, Gabapentin and Their Combination on Postoperative Analgesia after Thyroid Surgery

Cited by 5 publications

References 47 publications

Effect of Perioperative Intravenous Lignocaine Infusion on Haemodynamic Responses and postoperative Analgesia in Laparoscopic Cholecystectomy Surgeries

Effect of Perioperative Intravenous Lignocaine Infusion on Haemodynamic Responses and postoperative Analgesia in Laparoscopic Cholecystectomy Surgeries

Analgesic efficacy of Intraoperative lidocaine infusion in patients undergoing thyroidectomy

Effects of Perioperative Lidocaine Infusion on Pain Management and Quality of Recovery Following Thyroid Surgery: A Systematic Review and Meta-analysis

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