Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics

Galati, Giuseppe; Sabzevari, Omid; Wilson, John X.; O’Brien, Peter J.

doi:10.1016/s0300-483x(02)00198-1

Cited by 466 publications

(319 citation statements)

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“…This is despite the fact that there is no consensus as to its modes of action (Bhullar & Hubbard, 2015; Bitterman & Chung, 2015). In particular, RSV might act as an antioxidant, but other redox effects have also been documented (e.g., Miura et al ., 2000; Stivala et al ., 2001; Galati et al ., 2002; Ahmad et al ., 2003, 2005; Zheng et al ., 2006; de la Lastra & Villegas, 2007; Gadacha et al ., 2009; Queiroz et al ., 2009; Gueguen et al ., 2015). In addition, numerous distinct specific targets have been identified and characterized (reviewed in Bhullar & Hubbard, 2015; Bitterman & Chung, 2015).…”

Section: Introductionmentioning

confidence: 99%

Antioxidants reveal an inverted U‐shaped dose‐response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans

et al. 2016

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SummaryReactive oxygen species (ROS) are potentially toxic, but they are also signaling molecules that modulate aging. Recent observations that ROS can promote longevity have to be reconciled with the numerous claims about the benefits of antioxidants on lifespan. Here, three antioxidants [N‐acetylcysteine (NAC), vitamin C, and resveratrol (RSV)] were tested on Caenorhabditis elegans mutants that alter drug uptake, mitochondrial function, and ROS metabolism. We observed that like pro‐oxidants, antioxidants can both lengthen and shorten lifespan, dependent on concentration, genotypes, and conditions. The effects of antioxidants thus reveal an inverted U‐shaped dose–response relationship between ROS levels and lifespan. In addition, we observed that RSV can act additively to both NAC and paraquat, to dramatically increase lifespan. This suggests that the effect of compounds that modulate ROS levels can be additive when their loci of action or mechanisms of action are sufficiently distinct.

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Section: Introductionmentioning

confidence: 99%

Antioxidants reveal an inverted U‐shaped dose‐response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans

et al. 2016

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“…Also, flavonoids containing phenol B rings (33) and in general dietary polyphenols (34) can be oxidized by peroxidase/H 2 O 2 to give reactive aryloxy radicals.…”

Section: Enzymatic Methods For Total Polyphenols Determinationmentioning

confidence: 99%

New Enzymatic Method for the Determination of Total Phenolic Content in Tea and Wine

Stevanato¹,

Fabris²,

Momo³

2004

J. Agric. Food Chem.

105

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A new spectrophotometric enzymatic method for the determination of total phenol content in tea and wine has been developed. The method is based on the peroxidase-catalyzed oxidation, by hydrogen peroxide, of phenols to phenoxyl radicals, which can react with aromatic substrates to form intensely colored adducts. In comparison with the widely used Folin-Ciocalteu method, this method appears to be more specific and more rapid and as a whole is not affected by the common interfering substances such as ascorbate, citrate, and sulfite. Numerous samples of teas and wines were analyzed by using the new method, and the results compared with those obtained by using the Folin and scavenging of DPPH methods. The differences of the total phenols content found by applying the three methods are discussed in terms of the different specificities of the analytical basis.

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“…These compounds are reported to have high scavenging ability due to the presence of an O-dihydroxy structure in the caffeoyl moiety, which confers great stability to the radical form and participates in the electron delocalisation (Braca et al, 2003). The presence of high contents of caffeic acid derivatives may also contribute to its lower pro-oxidant effect, because of the presence of a catechol ring (Galati, Sabzevari, Wilson, & OÕ Brien, 2002).…”

Section: Antioxidant Activitymentioning

confidence: 99%

Antioxidative properties of tronchuda cabbage (Brassica oleracea L. var. costata DC) external leaves against DPPH, superoxide radical, hydroxyl radical and hypochlorous acid

et al. 2006

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The ability of the aqueous extract of tronchuda cabbage (Brassica oleracea L. var. costata DC) external leaves to act as a scavenger of DPPH Å and reactive oxygen species (superoxide radical, hydroxyl radical and hypochlorous acid) was investigated. A phytochemical study was also undertaken, and thirteen phenolic compounds and five organic acids were identified and quantified. Tronchuda cabbage extracts exhibited antioxidant capacity in a concentration-dependent manner in all assays, although some pro-oxidant effect was also noticed. The samples with higher phenolic and organic acid contents displayed the major antioxidant potentials.

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Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics

Cited by 466 publications

References 50 publications

Antioxidants reveal an inverted U‐shaped dose‐response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans

Antioxidants reveal an inverted U‐shaped dose‐response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans

New Enzymatic Method for the Determination of Total Phenolic Content in Tea and Wine

Antioxidative properties of tronchuda cabbage (Brassica oleracea L. var. costata DC) external leaves against DPPH, superoxide radical, hydroxyl radical and hypochlorous acid

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