Promotion of intestinal carcinogenesis by Streptococcus bovis

Ellmerich, Stéphan; Schöller, M; Duranton, B; Gossé, Francine; Galluser, M.; Klein, Jean‐Paul; Raul, Françis

doi:10.1093/carcin/21.4.753

Cited by 219 publications

(168 citation statements)

References 18 publications

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“…This group also reported no significant associations of S. bovis with malignant colon tissue using culture techniques, but a study using qPCR detected significantly more S. bovis DNA in tumor tissue compared with normal tissue in the same host [83]. An increase in polyamines associated with an increase in ACF was reported after S. bovis administration [84]. A recent metaanalysis suggests that a specific biotype, Streptococcus gallolyticus (S. bovis Biotype 1), is more closely associated with CRC [66].…”

Section: Evidence For Correlations Of Microbiota With Crcmentioning

confidence: 97%

Evidence for Contributions of Gut Microbiota to Colorectal Carcinogenesis

Culpepper¹,

Mai

2012

Curr Nutr Rep

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The contributions of the commensal gut microbiota to the maintenance of human health have long been contemplated. Whereas earlier studies were limited by an inability to analyze microbiota in sufficient depth, recent advances in the application of high throughput sequencing have allowed for an in-depth microbiota analysis in large numbers of individuals. Multiple lines of evidence have been generated that are supportive of an active role of gut microbiota in colorectal carcinogenesis. Although no single microbe has yet been shown to be causally linked to CRC, contributions of the gut microbiota to colorectal carcinogenesis are evident. Further advances in the field, which should include prospective studies in high-risk cohorts, should generate the data needed to start translating findings into microbiota-based screening and prevention regimen that can help to reduce the burden of CRC.

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Section: Evidence For Correlations Of Microbiota With Crcmentioning

confidence: 97%

Evidence for Contributions of Gut Microbiota to Colorectal Carcinogenesis

Culpepper¹,

Mai

2012

Curr Nutr Rep

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“…Men tend to be more affected than women (1.7:1); however, the age of the affected individuals increased from 30-40 years in the pre-antibiotic era to 47-69 in the recent years. In developed countries, the degenerative valvular alterations and prostheses, and no longer rheumatic disease, are the most important predisposing factors for the occurrence of endocarditis 1,3,4 .…”

Section: Discussionmentioning

confidence: 99%

“…It represents from 7% to 14% of the cases of subacute endocarditis and is often associated with colonic neoplasia. The incidence of this association is around 18% to 62% 4 . The colonic neoplasia can appear years after the infectious event.…”

Section: Discussionmentioning

confidence: 99%

Endocardite infecciosa por Streptococcus bovis em paciente com carcinoma colônico

Barcelos¹,

Teixeira²,

Alves³

et al. 2010

Arq. Bras. Cardiol.

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Bacterial endocarditis; adenocarcinoma; Streptococcus bovis; aortic valve insufficiency.We report the case of a 66 year-old female patient with infectious endocarditis due to Streptococcus bovis and adenocarcinoma of the colon that developed acute aortic insufficiency. She was submitted to aortic valve replacement surgery and later to tumor resection (right hemicolectomy). It is important to emphasize the need for complementing the study of the colon, even in asymptomatic individuals, when infectious endocarditis due to S. bovis is diagnosed. After being stabilized, she was referred to the Cardiology Infirmary for investigation. Infectious Endocarditis due toAt the time, she reported a picture of fatigue at exertion for the previous three years and a worsening of the situation for a month prior to hospitalization, associated with febrile episodes (no predilection for the time of the day), nausea and generalized arthralgia. At the physical examination, the patient was febrile, pale (+/4+), presented diastolic murmur with aortic focus and aortic accessory (+++/4+), as well as pulmonary crackles. The remainder of the physical examination was normal. Laboratory assessment: hemoglobin = 11g/dl, hematocrit = 32%, hemosedimentation velocity (HSV) = 120 mm. The chest x-ray showed enlargement of the cardiac area. The echocardiogram showed slightly increased left atrium and ventricle. The pulmonary arterial pressure was 42 mmHg. The aortic valve was thickened, with a cusp fragment projecting to the LVOT (left ventricular outflow tract) in diastole. She presented a slight MI and significant AI. The left ventricular (LV) systolic function was preserved. The transesophageal echocardiogram (Figure 1 Therapy with crystalline penicillin and amikacin was initiated even before the result of the blood cultures was available. On the subsequent days, the patient presented a good clinical picture evolution and symptom improvement without fever. She received amikacin for 14 days and penicillin for 28 days.A colonoscopy was carried out, which disclosed the presence of a sessile polyp in the transversal colon and a plane tumor at the hepatic angle (Figure 2). The histopathological analysis showed it was a well-differentiated and infiltrating adenocarcinoma.After the end of the antibiotic therapy, a new control echocardiogram showed the persistence of the significant aortic failure and the patient was referred to aortic valve replacement surgery. The surgical procedure was uneventful and the patient presented a favorable postoperative evolution, which allowed her hospital discharge on the 6 th postoperative day. The valve culture was negative.

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“…It would be of interest to substantiate any relationship between bacterial colonic carriage, colonic polyps and the type of polyp and its malignant potential (Boleij et al, 2009a;Schlegel et al, 2003). Contrary to the more commonly reported association between S. bovis/gallolyticus bacteremia and colorectal cancer, a link to pre-neoplastic adenomatous polyps was less frequently reported (Burns et al, 1985;Ellmerich et al, 2000a). Nevertheless, the relationship between colorectal bacterial infection and the progressive development of malignant disease in pre-neoplastic adenomatous polyps was supported by recent reports (Abdulamir et al, 2009;Kahveci et al, 2010;Murinello et al, 2006).…”

Section: The Association Of Premalignant Colorectal Lesions With S Bmentioning

confidence: 99%