Streptococcus bovis/gallolyticus Induce the Development of Colorectal Cancer

Abdulamir, Ahmed Sahib; Hafidh, Rand R.; Bakar, Fatimah Abu

doi:10.5772/29638

Cited by 2 publications

(3 citation statements)

References 64 publications

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“…nucleatum were higher in CRC patients and those with high-grade dysplasia lesions in comparison with those who had normal mucosa. Another important bacterial marker is S. bovis which has been linked to the development of CRC over a long period of time [ 41 ]. Corredoira et al [ 42 ] reported the connection of S. bovis with colon cancer in patients took into account the presence of premalignant adenomas which are usually considered as early-stage precursors of carcinomas.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the predictive performance of gut microbiota for the early-stage colorectal cancer

et al. 2022

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Background Colorectal cancer (CRC) has been regarded as one of the most frequently diagnosed malignancies among the leading causes of cancer-related morbidity and mortality globally. Diagnosis of CRC at the early-stages of tumour might improve the survival rate of patients. The current study sought to determine the performance of fecal Fusobacterium nucleatum (F. nucleatum) and Streptococcus bovis (S. bovis) for timely predicting CRC. Methods Through a case–control study, the fecal sample information of 83 individuals (38 females, 45 males) referring to a hospital in Tehran, Iran was used. All patients underwent a complete colonoscopy, regarded as a gold standard test. Bacterial species including S. bovis and F. nucleatum were measured by absolute quantitative real-time PCR. The Bayesian univariate and bivariate latent class models (LCMs) were applied to estimate the ability of the candidate bacterial markers in order to early detection of patients with CRC. Results Bayesian univariate LCMs demonstrated that the sensitivities of S. bovis and F. nucleatum were estimated to be 86% [95% credible interval (CrI) 0.82–0.91] and 82% (95% CrI 0.75–0.88); while specificities were 84% (95% CrI 0.78–0.89) and 80% (95% CrI 0.73–0.87), respectively. Moreover, the area under the receiver operating characteristic curves (AUCs) were 0.88 (95% CrI 0.83–0.94) and 0.80 (95% CrI 0.73–0.85) respectively for S. bovis and F. nucleatum. Based on the Bayesian bivariate LCMs, the sensitivities of S. bovis and F. nucleatum were calculated as 93% (95% CrI 0.84–0.98) and 90% (95% CrI 0.85–0.97), the specificities were 88% (95% CrI 0.78–0.93) and 87% (95% CrI 0.79–0.94); and the AUCs were 0.91 (95% CrI 0.83–0.99) and 0.88(95% CrI 0.81–0.96), respectively. Conclusions Our data has identified that according to the Bayesian bivariate LCM, S. bovis and F. nucleatum had a more significant predictive accuracy compared with the univariate model. In summary, these intestinal bacteria have been highlighted as novel tools for early-stage CRC diagnosis.

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Section: Discussionmentioning

confidence: 99%

Evaluating the predictive performance of gut microbiota for the early-stage colorectal cancer

et al. 2022

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“…Unfortunately, this association has been underestimated in the medical community, and the nomenclature trap in the literature and laboratories makes bacterial identification difficult. However, through the observation and adequate and timely monitoring of the patient, due to the possible pathogenic role of Streptococcus gallolyticus in colorectal cancer, it is possible to perform an early diagnosis and potentially curative treatment that saves the patient's life 4,5,[9][10][11][12][13][14][15][22][23][24] Therefore, the detection of this bacterial group in blood cultures or serum levels of elevated IgG antibodies against Streptococcus gallolyticus indicates the need for an evaluation to establish the origin of bacteremia and the presence of possible complications. 3,18,23,24 The present analysis describes a series of case reports that represent the evidence that exists between bacteraemia due to S. gallolyticus and its association with the presence of colorectal cancer and colorectal adenomas in patients with an average age of 65 years.…”

Section: Discussionmentioning

confidence: 99%

“…of colon through a report in which he made a complete evaluation of 15 patients with bacteraemia due to S. gallolyticus. 1,6,8,10,[13][14][15] With the report of Klein, a barrier that prevented directly related to Streptococcus was overcome gallolyticus with colorectal cancer, since through this study it was possible to formally establish the association that S. gallolyticus bacteremia has with the concomitant development of colorectal cancer, malignant or pre-malignant colorectal neoplasms and even with gastrointestinal neoplasms. This additionally suggests with certainty the performance of colonoscopy exams in infected patients, since the performance of colonoscopy after S. gallolyticus bacteremia could allow the detection of colorectal neoplasms in early or precancerous stages in affected patients, and thus, its clinical evolution would be beneficial for the reduction of morbidity and general mortality.…”

Section: Introductionmentioning

confidence: 94%

Association of bacteremias of Streptococcus gallolyticus with the development of colorectal cancer in people 65 years of age

Zurita¹,

Alejandra²

2018

MOJGG

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Objective: To establish the etiological mechanisms of Streptococcus gallolyticus bacteremia in the development of colorectal cancer in 65-year-olds. Methods: A review of articles published in PubMed, BioMed Central, Scielo, Elsevier, Springer, among others, was carried out using the following keywords: Streptococcus bovis and colorectal cancer, Streptococcus gallolyticus and colorectal cancer, Streptococcus gallolyticus Streptococcus bovis and Association between Streptococcus bovis and colorectal cancer ".Results: A total of 568 patients with colorectal cancer and a total of 362 patients with colorectal adenomas presenting with S. gallolyticus bacteremia were determined from a total of 15 case reports from the 1974 to 2017 period. Patient age was reported in the 15 reports with an average of 65 years. Conclusions:It was concluded that the association between colorectal tumors with S. gallolyticus appears to be of etiological naturel. Evidence presented through 15 case reports retrospectively assessed from the period 1974 to 2017 shows that there is a fundamental relationship between S, bovis bacteremia and colorectal cancer.Citation: Guillermo MZ, Alejandra NH. Association of bacteremias of Streptococcus gallolyticus with the development of colorectal cancer in people 65 years of age.

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Streptococcus bovis/gallolyticus Induce the Development of Colorectal Cancer

Cited by 2 publications

References 64 publications

Evaluating the predictive performance of gut microbiota for the early-stage colorectal cancer

Evaluating the predictive performance of gut microbiota for the early-stage colorectal cancer

Association of bacteremias of Streptococcus gallolyticus with the development of colorectal cancer in people 65 years of age

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