Promotion of glutathione-γ-glutamyl transpeptidase-dependent lipid peroxidation by copper and ceruloplasmin: The requirement for iron and the effects of antioxidants and antioxidant enzymes

Glass, G A; Stark, Avishay‐Abraham

doi:10.1002/(sici)1098-2280(1997)29:1<73::aid-em10>3.0.co;2-e

Cited by 44 publications

(29 citation statements)

References 17 publications

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“…Although the actual radical that initiates LDL oxidation has not been identified in this case, the reductant species has been proposed to be superoxide, because experimental evidence has been provided that, in metal-ion-free medium, cell-derived superoxide accounts quantitatively for the contribution of vascular cells to ceruloplasmin-dependent LDL oxidation [82]. A different mechanism underlines the enhancement of lipid peroxidation by catalytic amounts of ceruloplasmin in the presence of iron plus glutathione (GSH)-derived thiols or ascorbate, a system which is also able to promote mutagenesis [84]. In this system, the thiols produced by enzymatic cleavage of GSH by g-glutamyl transpeptidase are strong reductants, and ceruloplasmin appears to facilitate electron transfer from thiols to iron, rather than directly producing oxygen radical species.…”

Section: Copper Incorporation During Biosynthesismentioning

confidence: 99%

Structure to function relationships in ceruloplasmin: a 'moonlighting' protein

Bielli

Calabrese

2002

Cellular and Molecular Life Sciences (CMLS)

199

155

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Specialised copper sites have been recruited during evolution to provide long-range electron transfer reactivity and oxygen binding and activation in proteins destined to cope with oxygen reactivity in different organisms. Ceruloplasmin is an ancient multicopper dase evolved to insure a safe handling of oxygen in some metabolic pathways of vertebrates. The presently available knowledge of its structure provides a glimpse of its plasticity, revealing a multitude of binding sites that point to an elaborate mechanism of multifunctional activity. Ceruloplasmin represents an example of a 'moonlighting' protein that overcomes the one gene-one structure-one function concept to follow the changes of the organism in its physiological and pathological conditions.

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Section: Copper Incorporation During Biosynthesismentioning

confidence: 99%

Structure to function relationships in ceruloplasmin: a 'moonlighting' protein

Bielli

Calabrese

2002

Cellular and Molecular Life Sciences (CMLS)

199

155

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“…Whereas, nitrothiol adducts of NO function as NO transporters and are involved in modulation of intracellular and intercellular signal transduction (Akailke, 2000). Moreover, different mechanism highlight the enhancement of LPO by catalytic amounts of ceruloplasmin in the presence of iron plus GSH-derived thiols or ascorbate, a system which is also able to promote mutagenesis (Glass and Stark, 1997). In contrast, Beieli and Calabrese (2002) claimed that ceruloplasmin could benefit the organism under some pathophysiological conditions, such as neovascularization of injured tissues.…”

Section: Discussionmentioning

confidence: 99%

The protective role of 3-aminothiazolo[3-2a]benzimadzole-2-carbonitrile against lung and colon injury induced by nitrosomorpholine in adult male albino rat

Omar¹,

Abd-Allah²,

El-Din³

et al. 2013

J. Toxicol. Environ. Health Sci.

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Nitrites and morpholine are ubiquitous environmental contaminants found in drinking water and food. NMOR can be formed endogenously from nitrite and morpholine. Increased levels of reactive oxygen species/ reactive nitrite species (ROS/RNS) are involved in the mechanism of NMOR toxicity. Certain antimicrobial, antifungal and antioxidant potential were observed in heterocyclic benzimidazole derivatives and dimethyl sulfoxide (DMSO). This study was designed to evaluate the biological potential of 3-aminothiazolo[3-2a]benzimadzole-2-carbonitrile in the protection of lung and colon tissues against the increased levels of ROS/RNS that are induced by administration of nitrite and morpholine in drinking water for 15 weeks. Forty adult male rats were categorized into 4 groups, 10 rats each. The results showed a significant increase in NO, lipid peroxidation (LPO), total peroxides (TPO), superoxide anion (O 2 -) and DNA fragmentation in lung and colon tissues of rats treated with nitrite and morpholine compared to the control group. Moreover, histological observation of the lung and colon tissues showed cell necrosis, increase in the leukocyte infiltration and blood vessel congestion. Immunostaining for inducible nitric oxide synthase (iNOS) showed positive reaction for lung and colon tissues. After the co-treatment of rats with DEMSO and 3-aminothiazolo[3-2a]benzimadzole-2-carbonitrile, all the previous biochemical changes were reduced in addition to the relative improvement in the morphological changes of both lung and colon. In conclusion, the injury in lung and colon tissues induced by nitrite and morpholine may return to the increased production of ROS and to the alterations in the levels of antioxidants. Co-treatment of rats with 3-aminothiazolo[3-2a]benzimadzole-2-carbonitrile and DMSO may protect them against nitrite and morpholine toxicity.

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“…In this redox cycle, reactive oxygen radicals can be produced through Fenton-like reactions (Goldstein and Czapski 1986). Therefore, it is assumed that reactive copper can lead to oxidative cell damage, such as lipid peroxidation, thiol oxidation, and DNA damage (Glass andStark 1997, Li andTrush 1993).…”

Section: Volume 22mentioning

confidence: 99%

Copper and its inorganic compounds [MAK Value Documentation, 2006]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series MAK Value Documentations , Vol. 22 (2006) The article contains sections titled: Toxic Effects and Mode of Action Mechanism of Action Toxicokinetics and Metabolism Effects in Humans Single exposures Repeated exposures Local effects on skin and mucous membranes Allergenic effects Reproductive toxicity Carcinogenicity Animal experiments and in vitro studies Acute toxicity Subacute, subchronic and chronic toxicity Local effects on skin and mucous membranes Allergenic effects Reproductive toxicity Genotoxicity Carcinogenicity Other effects Manifesto (MAK value/classification)

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Promotion of glutathione-γ-glutamyl transpeptidase-dependent lipid peroxidation by copper and ceruloplasmin: The requirement for iron and the effects of antioxidants and antioxidant enzymes

Cited by 44 publications

References 17 publications

Structure to function relationships in ceruloplasmin: a 'moonlighting' protein

Structure to function relationships in ceruloplasmin: a 'moonlighting' protein

The protective role of 3-aminothiazolo[3-2a]benzimadzole-2-carbonitrile against lung and colon injury induced by nitrosomorpholine in adult male albino rat

Copper and its inorganic compounds [MAK Value Documentation, 2006]

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