Promotion of bacterial translocation by major liver resection in obstructive jaundice in rats colonised predominantly with indigenous Escherichia coli

Narioka, Junji; Nishi, Masaharu; Ogata, Yorihiko; Kuwahara, Tomomi; Nakayama, Haruyuki; Tashiro, Seiki; Ohnishi, Yoshinari

doi:10.1099/0022-1317-51-8-687

Cited by 11 publications

(9 citation statements)

References 35 publications

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“…It was reported by many studies that BT is provided by the lymphatic system (25,26). Reporting no growth in the blood samples from operated rats, but the first and greatest growth in mesenteric lymph nodes, the present study similarly supports the view that lymphatic system is essential way for BT.…”

Section: Discussionsupporting

confidence: 79%

Effects on Bacterial Translocation of High-Fat Enteral Nutrition in Bile Duct Ligated Rats

Elipek¹,

Utkan²

2012

Balkan Med J

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Objective: Bacterial Translocation (BT) from the gastrointestinal system is at the center of current sepsis theories. In patients with obstructive jaundice, the absence of intraluminal bile flow causes some alterations and mucosal damage in the gut. In the present study, it was aimed to investigate the effects on BT of high-fat enteral nutrition in bile duct ligated rats. Material and Methods:In this study, a total of 28 healthy Spraque-Dawley rats, weighing 230-300 gr, were grouped into four as sham group, control group, high-fat enteral nutrition group and low-fat enteral nutrition group. The rats in all the groups were sacrificed on the seventh postoperative day The values of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), total and direct bilirubin were measured for biochemical evaluation. Also, samples were taken from the blood, lung, liver, spleen and mesenteric lymph nodes for microbiological evaluation. The results were calculated as CFU/gr and evaluated statistically.Results: In all bile duct ligated rats, all findings of obstructive jaundice were observed clinically (in postoperatively third day) and in the laboratory. It was determined that the lymphatic system is an essential pathway for BT, as reported by similar studies. However, it was observed in this study that the high-fat enteral nutrition may be not severely effective in reducing BT in bile duct ligated rats. The results were supported by statistical analyses. Conclusion:It was observed that high-fat enteral nutrition has no meaningful effects on reducing BT in bile duct ligated rats.

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Section: Discussionsupporting

confidence: 79%

Effects on Bacterial Translocation of High-Fat Enteral Nutrition in Bile Duct Ligated Rats

Elipek¹,

Utkan²

2012

Balkan Med J

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“…Bacteria translocated into the bloodstream might be quickly sequestered and killed by the improved RES function by immunonutrition [25]. It is also highly probable that immunonutrition either prevented migration of bacteria or abolished their presence effectively.…”

Section: Discussionmentioning

confidence: 99%

Effect of Different Enteral Nutrients on Bacterial Translocation in Experimental Obstructive Jaundice

Kuru¹,

Dinç²,

Altınok

et al. 2004

Eur Surg Res

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Obstructive jaundice leads to bacterial translocation (BT) by disruption of the gut barrier, intestinal microecology, and impaired host immune defence. The objective of the present study is to investigate the effects of different enteral nutrients on BT that is induced by obstructive jaundice in rats. Eighty male Wistar-Albino rats were randomly assigned into 4 groups. Group 1: 20 rats underwent laparotomy, common bile duct (CBD) was not actually ligated and transected, but sham ligation of CBD was performed. Groups 2–4: 60 rats underwent laparotomy, CBD ligation and transection. Group 1 and 2 rats were given rat chow, group 3 rats were fed a glutamine and arginine supplemented enteral diet, and group 4 rats were fed an arginine, m-RNA and ω-3 supplemented enteral diet, an immunonutrient. Rats in groups 3 and 4 had significantly less BT to mesenteric lymph nodes compared to rats in group 2 (p = 0.001). These findings suggest that oral administration of an arginine and glutamine supplemented diet and immunonutrition reduce BT in rats with obstructive jaundice.

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“…Interestingly, Cai and coauthors demonstrated that administration of lovastatin significantly improved two-wk survival and metabolic functions in an experimental model of 90% hepatectomy [12]. It is well known that hepatectomy causes bacterial translocation from the intestine, which may be involved in post-operative sepsis and failure of the liver remnant [13][14][15]. However, it is not known whether statins may reduce hepatectomy-induced susceptibility to subsequent LPS-induced liver injury.…”

Section: Introductionmentioning

confidence: 92%

Simvastatin Attenuates Hepatic Sensitization to Lipopolysaccharide After Partial Hepatectomy

Slotta

Laschke

Schilling

et al. 2010

Journal of Surgical Research

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Promotion of bacterial translocation by major liver resection in obstructive jaundice in rats colonised predominantly with indigenous Escherichia coli

Cited by 11 publications

References 35 publications

Effects on Bacterial Translocation of High-Fat Enteral Nutrition in Bile Duct Ligated Rats

Effects on Bacterial Translocation of High-Fat Enteral Nutrition in Bile Duct Ligated Rats

Effect of Different Enteral Nutrients on Bacterial Translocation in Experimental Obstructive Jaundice

Simvastatin Attenuates Hepatic Sensitization to Lipopolysaccharide After Partial Hepatectomy

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