Promotion of anti-smoking strategies as the most effective and efficient way to reduce lung cancer (and other diseases)

Ruano-Raviña, Alberto; Provencio-Pulla, Mariano; Fernández-Villar, José Alberto

doi:10.1016/j.arbr.2019.12.003

Cited by 1 publication

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“…As all we know, smoking is the main risk factor for lung cancer. Anti-smoking strategies are the most effective and efficient way to reduce the high incidence and mortality of lung cancer ( 28 ). Through the relationship between CMTM4 expression and smoking status of lung cancer patients, we can conclude some etiology of lung cancer caused by smoking.…”

Section: Discussionmentioning

confidence: 99%

Expression of CMTM4 shows clinical significance in lung cancer

Zhu¹,

Zhang²,

Tan³

et al. 2020

Transl Cancer Res TCR

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Background: Human chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM) is implicated in the pathogenesis of immune, reproductive systems and various cancers.However, the expression and clinical significance of CMTM4 in lung cancer have not been identified. Methods: We performed immunohistochemistry to detect the expression of CMTM4 in 75 paired lung adenocarcinoma and non-tumor lung tissues. The correlation between CMTM4 expression and clinical significance of lung cancer patients was analyzed by Chi-square test. Kaplan-Meier method and Log-Rank test were used to calculate the survival time of lung cancer patients.Results: We found that CMTM4 was positively expressed in 34/75 (45.3%) cases of lung adenocarcinoma tissues, while positively expressed in 59/75 (78.6%) cases of non-tumor lung tissues, suggesting a lower expression of CMTM4 in lung adenocarcinoma tissues than non-tumor lung tissues (P<0.05). In addition, the negative expression of CMTM4 was associated with gender, smoking, and metastasis in lung cancer patients. Moreover, lung cancer patients with negative expression of CMTM4 had a shorter survival time than the patients with positive expression of CMTM4. COX regression analysis showed that CMTM4 was an independent prognostic factor for the overall survival of lung cancer patients.Conclusions: Our study supports that CMTM4 can be used as a new marker for the treatment and prognosis of lung cancer.

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Section: Discussionmentioning

confidence: 99%