Expression of CMTM4 shows clinical significance in lung cancer

Abstract

Background: Human chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM) is implicated in the pathogenesis of immune, reproductive systems and various cancers.However, the expression and clinical significance of CMTM4 in lung cancer have not been identified. Methods: We performed immunohistochemistry to detect the expression of CMTM4 in 75 paired lung adenocarcinoma and non-tumor lung tissues. The correlation between CMTM4 expression and clinical significance of lung cancer patients was analyzed by Chi-square test. Kaplan-Meier method and Log-Rank test were used to calculate the survival time of lung cancer patients.Results: We found that CMTM4 was positively expressed in 34/75 (45.3%) cases of lung adenocarcinoma tissues, while positively expressed in 59/75 (78.6%) cases of non-tumor lung tissues, suggesting a lower expression of CMTM4 in lung adenocarcinoma tissues than non-tumor lung tissues (P<0.05). In addition, the negative expression of CMTM4 was associated with gender, smoking, and metastasis in lung cancer patients. Moreover, lung cancer patients with negative expression of CMTM4 had a shorter survival time than the patients with positive expression of CMTM4. COX regression analysis showed that CMTM4 was an independent prognostic factor for the overall survival of lung cancer patients.Conclusions: Our study supports that CMTM4 can be used as a new marker for the treatment and prognosis of lung cancer.

Serum lncRNA THRIL predicts benign and malignant pulmonary nodules and promotes the progression of pulmonary malignancies

“…Lung cancer is a debilitating disease, and it is one of the most death tumors in the world [ 20 ]. The majority of patients are already in the advanced to the advanced stage when they are diagnosed, so timely confirmation is essential to improve the survival outcome of lung tumor patients [ 21 , 22 ]. With the widespread application of chest CT, more and more SPNs have been diagnosed.…”

Current Opinions on the Relationship Between CMTM Family and Hepatocellular Carcinoma

“…51 This indicates that CMTM4 is involved in the process of cell cycle and affects the occurrence and development of disease, especially in the progression of tumors. [52][53][54][55] In order to better understand the part played by CMTM4 in the progression of HCC, Bei et al examined tissue samples from HCC patients through IHC staining. 50 When compared to matched neighboring non-tumor tissues, they noticed that the expression of CMTM4 was down-regulated in HCC tissues.…”