Current Opinions on the Relationship Between CMTM Family and Hepatocellular Carcinoma

Abstract

Hepatocellular carcinoma (HCC) is a typically malignant tumor in the digestive system. The mortality of HCC ranks third place in the world, second only to lung cancer and colorectal cancer. For the characteristics of high invasiveness, high metastasis, high recurrence rate as well as short survival time, HCC treatment has always been difficult in clinical practice. Many causes have contributed to the appearance of these features, including insidious onset, high degree of malignancy, lack of effective early molecular diagnostic markers, and disease prediction models. The human chemokine-like factor superfamily (CMTMs) is a new gene family consisting of CKLF and CMTM1-CMTM8. CMTMs have a marvel domain which can activate and chemotaxis immune cells. Many studies have reported that CMTMs are involved in the regulation of cell growth and development, and play an important role in the malignant progression of the immune system and reproductive system, especially in the development of tumors. In this review, we summarized the structure and function of the human CMTMs, the relationship between its family members and HCC, the prognostic value, potential functions, and mechanisms in HCC. CMTMs could provide a new diagnostic and therapeutic target in clinical practice for patients with HCC.

Prognostic significance of RKIP, TGM2, and CMTM4 expression in oral squamous cell carcinoma

“…CMTM4 is located at 16q22.1, and is expressed as a tumor suppressor gene in hepatocellular carcinoma, lung squamous cell carcinoma, esophageal cancer, ovarian cancer, and type I renal clear cell carcinoma. [ 6 – 8 , 12 – 14 , 29 ] The expression of CMTM4 is significantly upregulated in human HNSCC and HNSCC cell lines. Previous studies have shown that CMTM4 is involved in the induction of CSC phenotype and PD-L1 expression by regulating EMT in HNSCC.…”