Promotion effect of angelica sinensis extract on angiogenesis of chicken preovulatory follicles in vitro

Chen, Hao; Chen, Xin; Ping, Zhenlei; Jiang, Xiaowen; Ge, Ming; Ma, Jun; Yu, Wenhui

doi:10.1016/j.psj.2022.101938

Cited by 7 publications

(4 citation statements)

References 43 publications

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“…In an in vitro study of the preovulation follicles on chicken blood vessels, the extract of A. sinensis potentiated angiogenic activity, by enhancing the endothelial blood vessel growth through promoting the phosphorylation reaction involved in the activation of the endothelial growth factor receptor II [125].…”

Section: Effects On Cardio-and Cerebrovascular Systemsmentioning

confidence: 99%

Phytochemical Constituents, Folk Medicinal Uses, and Biological Activities of Genus Angelica: A Review

et al. 2022

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Genus Angelica is one of the widely distributed and well-known genera of family Umbelliferae. It is utilized mainly by Chinese and Korean populations especially in their folk medicine. Angelica comprises a lot of medicinally important phytoconstituents such as coumarins, furanocoumarins, flavonoids, essential oils, verbascosides, polysaccharides, etc. Members of this genus play important roles, namely antioxidant, anti-inflammatory, anti-microbial, anti-diabetic, skin-whitening, cytotoxic, hepatoprotective, and many others. This review draws attention to many species of genus Angelica with much focus on A. dahurica being one of the highly medicinally used species within this genus.

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Section: Effects On Cardio-and Cerebrovascular Systemsmentioning

confidence: 99%

Phytochemical Constituents, Folk Medicinal Uses, and Biological Activities of Genus Angelica: A Review

et al. 2022

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“…Angelica sinensis, also known as “female ginseng”, is renowned for treating various gynaecological conditions [ 22 ]. Angelica sinensis extract could enhance the invasion and migration ability of follicle micro-vascular endothelial-like cells of chicken in vitro and promote the proliferation of granulosa cells [ 23 ]. Paeonia lactiflora Pall has long been used to treat female infertility and recurrent miscarriages.…”

Section: Discussionmentioning

confidence: 99%

ErZhiTianGui Decoction alleviates age-related ovarian aging by regulating mitochondrial homeostasis and inhibiting ferroptosis

Zhicheng,

Yongqian,

Peixuan

et al. 2024

J Ovarian Res

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Aim This study was designed to investigate the pharmacological effects and mechanisms of ErZhiTianGui Decoction (EZTG) for age-related ovarian aging in mice. Methods This study used naturally aging mice as a model, and EZTG was used for intragastric administration. Ovarian pathological changes, as well as follicular reserve were assessed by hematoxylin and eosin staining, and serum hormone levels (anti-mullerian hormone, follicle-stimulating hormone), mitochondrial reactive oxygen species (ROS) and mitochondrial DNA (mtDNA) damage marker 8-hydroxy-2′-deoxyguanosine(8-OHdG), and lipid peroxidation markers glutathione(GSH) and malondialdehyde(MDA) were determined by enzyme-linked immunosorbent assay. Mitochondrial membrane potential (MMP) levels in ovaries were determined using flow cytometry. The levels of PINK1 and Parkin were observed using immunofluorescence staining. Mitochondrial-derived vesicles (MDVs) and mitochondrial morphology were observed using electron microscopy. Prussian blue staining was used to observe iron ion aggregation in ovarian tissue. The Iron assay kits detected total iron levels. Western blot was used to detect the expression of proteins related to mitochondrial and ferroptosis related genes. Results After EZTG treatment, aged mice showed increased ovarian reserve, improved serum hormone levels, increased MMP, GSH levels, and decreased mitochondrial ROS, 8-OHdG, and MDA levels. Immunofluorescence staining showed decreased levels of PINK1 and Parkin, and the same trend was observed for the Western blot. Meanwhile, electron microscopy showed that EZTG improved the mitochondrial morphology in the ovaries of aged mice. EZTG also decreased the total iron and protein levels of Acyl-CoA synthetase long-chain family4 (ACSL4) and increased the protein level of glutathione peroxidase 4 (GPX4) in the ovaries of aged mice. Conclusions EZTG can maintain PINK1/Parkin-mediated mitochondrial homeostasis, reduce the lipid peroxidation caused by the accumulation of ROS, and inhibit the occurrence of ferroptosis and delaying ovarian aging. These findings suggest that EZTG may be a promising drug for treating age-related ovarian aging in females.

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“…We have successfully isolated primary GCs and FMECs from chicken preovulatory follicles according to the previously described methods ( Chen et al, 2022a ). Briefly, hens aged 30 wk which laying rate was more than 90% were used in this study.…”

Section: Methodsmentioning

confidence: 99%

Ligusticum chuanxiong promotes the angiogenesis of preovulatory follicles (F1–F3) in late-phase laying hens

Chen¹,

Chen²,

Ping³

et al. 2023

Poultry Science

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Promotion effect of angelica sinensis extract on angiogenesis of chicken preovulatory follicles in vitro

Cited by 7 publications

References 43 publications

Phytochemical Constituents, Folk Medicinal Uses, and Biological Activities of Genus Angelica: A Review

Phytochemical Constituents, Folk Medicinal Uses, and Biological Activities of Genus Angelica: A Review

ErZhiTianGui Decoction alleviates age-related ovarian aging by regulating mitochondrial homeostasis and inhibiting ferroptosis

Ligusticum chuanxiong promotes the angiogenesis of preovulatory follicles (F1–F3) in late-phase laying hens

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