Promoting role of pentraxin-3 in esophageal squamous cell carcinoma

Fan, Zhirui; Zheng, Yuanyuan; Li, Xiaoli; Deng, Xiaoming; Ba, Yan; Feng, Ke; Wang, Hui; Suo, Zhenhe; Li, Lifeng

doi:10.1016/j.omto.2022.02.005

Cited by 7 publications

(8 citation statements)

References 33 publications

(42 reference statements)

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“…PTX3 belongs to the long pentraxin subfamily and plays a critical role in modulating inflammation, innate immunity response, angiogenesis, and tissue remodeling 41 . Our investigation reveals that PTX3 is upregulated in all four SCCs with a dismal prognosis, corroborating the findings of several antecedent studies 42–46 . While some research posits that heightened PTX3 levels serve as an adverse prognostic indicator, others attribute this upregulation to the inherently inflammatory condition of the tumor microenvironment.…”

Section: Discussionsupporting

confidence: 84%

“…41 Our investigation reveals that PTX3 is upregulated in all four SCCs with a dismal prognosis, corroborating the findings of several antecedent studies. [42][43][44][45][46] While some research posits that heightened PTX3 levels serve as an adverse prognostic indicator, others attribute this upregulation to the inherently inflammatory condition of the tumor microenvironment. The active involvement of activated endothelial cells, tumor-associated fibroblasts, and infiltrating immune cells in the synthesis and secretion of PTX3.…”

Section: Discussionmentioning

confidence: 99%

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Systematical identification of key genes and regulatory genetic variants associated with prognosis of esophageal squamous cell carcinoma

Gu,

Yue,

Niu

et al. 2024

Molecular Carcinogenesis

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Esophageal squamous cell carcinoma (ESCC) stands as a highly lethal malignancy characterized by pronounced recurrence and metastasis, resulting in a bleak 5‐year survival rate. Despite extensive investigations, encompassing genome‐wide association studies, the identification of robust prognostic markers has remained elusive. In this study, leveraging four independent data sets comprising 404 ESCC patients, we conducted a systematic analysis to unveil pivotal genes influencing overall survival. our meta‐analysis identified 278 genes significantly associated with ESCC prognosis. Further exploration of the prognostic landscape involved an examination of expression quantitative trait loci for these genes, leading to the identification of six tag single nucleotide polymorphisms predictive of overall survival in a cohort of 904 ESCC patients. Notably, functional annotation spotlighted rs11227223, residing in the enhancer region of nuclear paraspeckle assembly transcript 1 (NEAT1), as a crucial variant likely exerting a substantive biological role. Through a series of biochemistry experiments, we conclusively demonstrated that the rs11227223‐T allele, indicative of a poorer prognosis, augmented NEAT1 expression. Our results underscore the substantive role of NEAT1 and its regulatory variant in prognostic predictions for ESCC. This comprehensive analysis not only advances our comprehension of ESCC prognosis but also unveils a potential avenue for targeted interventions, offering promise for enhanced clinical outcomes.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Systematical identification of key genes and regulatory genetic variants associated with prognosis of esophageal squamous cell carcinoma

Gu,

Yue,

Niu

et al. 2024

Molecular Carcinogenesis

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“…Previous studies have shown both that PTX3 is overexpressed in various tumors, and that it is involved in cancer progression through multiple signaling pathways ( 28 , 29 ). A recently published study ( 30 ) demonstrated that the transcription factor SOX9 directly regulates the expression of PTX3, whereas human leukocyte antigen system-associated genes are significantly upregulated when PTX3 is lacking in esophageal carcinoma (ESCA). Knockout of PTX3 in ESCA was also demonstrated to lead to increases in cell apoptosis and sensitivity to chemotherapy and radiotherapy ( 30 ).…”

Section: Discussionmentioning

confidence: 99%

PTX3 promotes breast cancer cell proliferation and metastasis by regulating PKCζbreast cancer, pentraxin 3, protein kinase Cζ, proliferation, metastasis

Wu,

Yang,

et al. 2024

Exp Ther Med

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Breast cancer (BC) is the most commonly diagnosed cancer in women, providing a leading cause of death from malignancy. Pentraxin 3 (PTX3) and protein kinase C ζ (PKCζ) are both known to exert important roles in the progression of multiple types of tumors, including BC. The present study aimed to explore both their interaction and their role in promoting the proliferation and metastasis of BC. The expression level of PTX3 was found to be elevated both in patients with BC and in BC cells; furthermore, it was found to be associated with lymph node metastasis in patients with BC. Knockdown of PTX3 decreased the rate of cell proliferation and the effects of a series of metastasis-associated cellular processes, including cell chemotaxis, migration, adhesion and invasion, as well as diminishing actin polymerization of the MDA-MB-231 and MCF7 BC cells, and decreasing tumor pulmonary metastasis in vivo . Mechanistically, PTX3 and PKCζ were found to be colocalized intracellularly, and they were co-translocated to the cell membrane upon stimulation with epidermal growth factor. Following the knockdown of PTX3, both the phosphorylation and membrane translocation of PKCζ were significantly impaired, suggesting that PTX3 regulates the activation of PKCζ. Taken together, the findings of the present study have shown that PTX3 may promote the proliferation and metastasis of BC cells through regulating PKCζ activation to enhance cell migration, cell chemotaxis, cell invasion and cell adhesion.

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“…SEMA3G also take part in tumor of reproductive system and nervous system [31,32]. The higher expression PTX3 would promote esophageal squamous cell carcinoma occurrence and promote cancer migrate by a toll-like receptor 4 (TLR4)/NF-kappaB signaling pathway [33,34]. The difference of disease prognosis and tumor clinical stage showed the various situation of PTX3 expression [33,35].…”

Section: Discussionmentioning

confidence: 99%

Development and Validation of an Individualized Immune Prognostic Signature in HNSCC

Sun

Zhao

et al. 2022

Preprint

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Head and neck cancer is the seventh most common type of cancer worldwide, and the development of immunotherapy is conducive to the preservation of function and the improvement of prognosis. Based on immune gene database ImmPort and InnateDB, we investigated prognostic value of 546 head and necks squamous cell carcinoma samples from The Cancer Genome Atlas. We intersected of the two databases, selected specific module by WGCNA, and then performed univariate and multivariate Cox regression analyses to screen their prognostic roles in HNSCC patients. Three prognostic immune genes were identified as prognostic gene, including DEFB1, PTX3and SEMA3G. According to the risk scores of patients, we divided HNSCC patients into low- and high-risk subgroups by the median value of risk scores in each dataset. In addition, we calculated immune cells and immune infiltration of the two groups and constructed K-M survival curve plot based on immune infiltration result. Enrichment analysis indicated that cytokines and cytokine receptors interaction was more common in the specific immune gene module. Moreover, we constructed a nomogram based on the results of multivariate cox analysis and clinical information and confirmed the survival of the two groups by using two GEO database. We also established a correlation analysis between immune prognostic signature genes and immune checkpoints. Finally, we believed that PTX3 was the key gene, and the expression levels of PTX3 in 30 clinical samples was detected by immunohistochemical method. In conclusion, PTX3 is a key immune gene, which may contribute to poor prognosis of HNSCC by affecting TME.

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Promoting role of pentraxin-3 in esophageal squamous cell carcinoma

Cited by 7 publications

References 33 publications

Systematical identification of key genes and regulatory genetic variants associated with prognosis of esophageal squamous cell carcinoma

Systematical identification of key genes and regulatory genetic variants associated with prognosis of esophageal squamous cell carcinoma

PTX3 promotes breast cancer cell proliferation and metastasis by regulating PKCζbreast cancer, pentraxin 3, protein kinase Cζ, proliferation, metastasis

Development and Validation of an Individualized Immune Prognostic Signature in HNSCC

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