Promoting Global Research Excellence in Severe Sepsis (PROGRESS): Lessons from an International Sepsis Registry

Beale, Richard; Reinhart, Konrad; Brunkhorst, Frank M.; Dobb, Geoffrey; Levy, Mitchell; Martin, Greg S.; Martin, Claudio M.; Ramsey, G.; Silva, E.; Vallet, B.; Vincent, Jean‐Louis; Janes, Jonathan; Sarwat, Samiha; Williams, Mark D.

doi:10.1007/s15010-008-8203-z

Cited by 159 publications

(132 citation statements)

References 45 publications

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“…A recent meta‐analysis of RCTs reported that the survival benefit of anticoagulant therapy was observed only in sepsis patients with DIC, but not in those without DIC 10. Furthermore, although many epidemiological studies for sepsis have been carried out,11, 12, 13, 14, 15 epidemiological data regarding sepsis in Japan is limited 16, 17…”

Section: Introductionmentioning

confidence: 99%

A summary of the Japan septic disseminated intravascular coagulation study

Hayakawa

Ono

2018

Acute Medicine & Surgery

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Over the past few decades, the large, international, randomized controlled trials of anticoagulant therapies for patients with sepsis have not yielded any improvement in mortality rates. However, in Japan, anticoagulant therapies are administered for sepsis patients with disseminated intravascular coagulation (DIC), but not for sepsis patients without DIC. Furthermore, epidemiological data regarding sepsis in Japan are scarce. Therefore, a nationwide multicenter retrospective observational study, the Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study, was undertaken. The JSEPTIC DIC study enrolled 42 intensive care units and included 3,195 patients with sepsis. The results of the JSEPTIC DIC study indicated the following: (i) anticoagulant therapy may be effective in sepsis‐induced DIC patients at high risk for death, (ii) recombinant human soluble thrombomodulin administration and antithrombin supplementation are associated with survival benefits in patients with sepsis‐induced DIC.

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Section: Introductionmentioning

confidence: 99%

A summary of the Japan septic disseminated intravascular coagulation study

Hayakawa

Ono

2018

Acute Medicine & Surgery

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“…(2,(18)(19)(20)(21)(22)(23) In Brazil it is higher than in other countries, 56% of mortality versus 30% in the developed countries and 45% in other developing countries. (2,24) Possibly these high rates are due to delay in starting therapy which greatly contributes to spreading of the inflammatory response and development of multiple organ dysfunction (MOD). Patients under treatment, even when appropriate, after multiple organ dysfunction have a worse prognosis.…”

Section: Discussionmentioning

confidence: 99%

Estratégia de detecção precoce e redução de mortalidade na sepse grave

Westphal¹,

Feijó²,

Andrade³

et al. 2009

Rev. bras. ter. intensiva

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Objective: To evaluate the impact of implementing an institutional policy for detection of severe sepsis and septic shock.Methods: Study before (stage I), after (stage II) with prospective data collection in a 195 bed public hospital.. Stage I: Patients with severe sepsis or septic shock were included consecutively over 15 months and treated according to the Surviving Sepsis Campaign guidelines. Stage II: In the 10 subsequent months, patients with severe sepsis or septic shock were enrolled based on an active search for signs suggesting infection (SSI) in hospitalized patients. The two stages were compared for demographic variables, time needed for recognition of at least two signs suggesting infection (SSIΔt), compliance to the bundles of 6 and 24 hours and mortality.Results: We identified 124 patients with severe sepsis or septic shock, 68 in stage I and 56 in stage II. The demographic variables were similar in both stages. The Δt-SSI was 34 ± 54 hours in stage I and 7 ± 8.4 hours in stage II (p <0.001). There was no difference in compliance to the bundles. In parallel there was significant reduction of mortality rates at 28 days (54.4% versus 30%, p <0.02) and hospital (67.6% versus 41%, p <0.003). Conclusion: The strategy used helped to identify early risk of sepsis and resulted in decreased mortality associated with severe sepsis and septic shock.

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“…Eldicus developed an ICU triage score in 11 European countries and found respiratory rate to be missing in 44% of 6796 patients triaged for ICU and 50% of 794 septic patients [13]. Data are mostly from the USA, where two qSOFA components predict mortality [3] but where mortality rates are lower than in LMICs [14]. Perhaps only one rather than two qSOFA components should be necessary, especially in LMICs with a higher mortality.…”

Section: The Badmentioning

confidence: 99%