Abstract:Materials and methods
MaterialsCaco-2 cell line was purchased from the Key Laboratory of Dairy of Northeast Agricultural University. NCM460 cell line was purchased from Guangzhou Biotechnology Co., Ltd. Two strains of probiotics Lactophilus acidophilus (AS1.2686
“…Epidemiological data in 2016 showed that there were 53,070 new cases of pancreatic cancer in the United States, ranking the fourth place in the mortality of malignant tumors. In addition, the incidence rate of pancreatic cancer is increasing year by year (Sancho-Albero et al, 2020;Jiang et al, 2021). Pancreatic cancer is highly of malignant, with extremely poor prognosis (5-year survival rate less than 5%) (Goral, 2015;Heinrich & Lang, 2017).…”
The aim of the present study was to investigate the function and mechanism of SUFU in treatment of pancreatic cancer. Patient with pancreatic cancer (n = 50) and normal volunteers (n = 30) were obtained from The Second Affiliated Hospital of Soochow University between May 2014 and April 2013. SUFU mRNA and protein expressions in patients with pancreatic cancer were reduced as compared to normal saline. OS and DFS of high expression of SUFU in pancreatic cancer were higher than those of low expression of SUFU in pancreatic cancer. The inhibition of SUFU promoted pancreatic cancer cell growth and migration; SUFU reduced pancreatic cancer cell growth and migration. SUFU suppressed Wnt/β-catenin signaling pathway in pancreatic cancer cell lines. SUFU reduced pancreatic cancer cell growth by Wnt/β-catenin signaling pathway, providing a novel possibility for an understanding of pancreatic cancer pathogenesis.
“…Epidemiological data in 2016 showed that there were 53,070 new cases of pancreatic cancer in the United States, ranking the fourth place in the mortality of malignant tumors. In addition, the incidence rate of pancreatic cancer is increasing year by year (Sancho-Albero et al, 2020;Jiang et al, 2021). Pancreatic cancer is highly of malignant, with extremely poor prognosis (5-year survival rate less than 5%) (Goral, 2015;Heinrich & Lang, 2017).…”
The aim of the present study was to investigate the function and mechanism of SUFU in treatment of pancreatic cancer. Patient with pancreatic cancer (n = 50) and normal volunteers (n = 30) were obtained from The Second Affiliated Hospital of Soochow University between May 2014 and April 2013. SUFU mRNA and protein expressions in patients with pancreatic cancer were reduced as compared to normal saline. OS and DFS of high expression of SUFU in pancreatic cancer were higher than those of low expression of SUFU in pancreatic cancer. The inhibition of SUFU promoted pancreatic cancer cell growth and migration; SUFU reduced pancreatic cancer cell growth and migration. SUFU suppressed Wnt/β-catenin signaling pathway in pancreatic cancer cell lines. SUFU reduced pancreatic cancer cell growth by Wnt/β-catenin signaling pathway, providing a novel possibility for an understanding of pancreatic cancer pathogenesis.
“…[ 29 ] We posit that such outcomes are rooted in prebiotics’ ability to: (1) hinder bacterial metabolism by suppressing nucleotide synthesis, chelating essential ions, interacting with cell membrane components, and facilitating electron transfer, [ 28,70 ] (2) serve as a source of energy for intestinal microbiota, [ 30 ] and (3) foster adhesion of probiotics to cells. [ 71,72 ]…”
Section: Mechanisms Underlying the Efficacy Of Pro‐ And/or Prebiotics...mentioning
confidence: 99%
“…[29] We posit that such outcomes are rooted in prebiotics' ability to: (1) hinder bacterial metabolism by suppressing nucleotide synthesis, chelating essential ions, interacting with cell membrane components, and facilitating electron transfer, [28,70] (2) serve as a source of energy for intestinal microbiota, [30] and (3) foster adhesion of probiotics to cells. [71,72] Collectively, the aforementioned research bears witness to use of pro-and/or prebiotics for promoting the proliferation and diversity of beneficial bacteria while impeding populations of harmful microbes within the gut. The development of regimens that include pro-and/or prebiotics may be a novel paradigm for the prevention and treatment of CRC, although further investigations are required to determine which types, dosages, and usage frequencies are most appropriate.…”
Section: Balance Of the Intestinal Microflora Compositionmentioning
Colorectal cancer (CRC) is the third most common type of cancer, posing a serious threat to human life. It is widely believed that dietary factors may be crucial modifiers of CRC risk, with pro‐and/or prebiotics being especially promising. In this review, a synthesis of CRC prevention and treatment of strategies relying on usage of pro‐ and/or prebiotics supplements is given, as well as discuss mechanisms underlying the contribution of pro‐and/or prebiotics to the suppression of colonic carcinogenesis. Furthermore, a framework for personalizing such supplements according to the composition of an individual's gut microbiome is suggested. Various factors including diversity of one's intestinal microflora, integrity of their intestinal barrier, and the presence of mutagenic/carcinogenic/genotoxic and beneficial compounds are known to have a prominent influence on the development of CRC; thus, clarifying the role of pro‐ and/or prebiotics will yield valuable insight toward optimizing interventions for enhanced patient outcomes in the future.
“…Probiotics are supposed to be beneficial or to prevent the production of biogenic amines and act as bactericidal components. Thus, the adhesion of probiotics would be promoted the strengthen of the beneficial effects of probiotics (Buran et al, 2022;Jiang et al, 2021;Moghadam et al, 2022). Probiotics are harmless microorganisms that, when delivered to humans in sufficient concentrations and for long enough periods of time, have certain beneficial effects on the host.…”
The aim of this study was to produce a synbiotic product containing Thai-pigmented rice as the carrier and the honey of the stingless bee as the prebiotic agent. From antibacterial activity results, all of the tested probiotic bacteria (Limosilactobacillus reuteri KUKPS6103, Lacticaseibacillus rhamnosus KUKPS6007 and Lacticaseibacillus paracasei KUKPS6201) had a high ability to inhibit six strains of intestinal pathogens. All three probiotic bacterial strains had high antioxidant activity according to the ABTS and DPPH scavenging assays. The three tested probiotic bacteria produced substantial reductions in the cholesterol removal percentage of 33.9-78.99%. In the prebiotic studies, stingless bee honey had high enhancing activity and the main carbohydrate components were sucrose, glucose and fructose. A synbiotic product was produced containing Thai-pigmented rice grains (cultivars Riceberry, Tubtim Chumphae and Sangyod) and stingless bee honey. During 8 weeks of storage, the viability of the probiotics in terms of mixed-strains was 7.96 ± 0.06 log CFU g -1 (90.25% survival rate). Microbiological safety testing stated that the amounts of contaminants were acceptable. This is the first report of an application of Thai-pigmented rice, stingless bee honey and mixed-culture probiotics as a novel functional synbiotic product.
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