Intake of Pro‐ and/or Prebiotics as a Promising Approach for Prevention and Treatment of Colorectal Cancer

Abstract

Colorectal cancer (CRC) is the third most common type of cancer, posing a serious threat to human life. It is widely believed that dietary factors may be crucial modifiers of CRC risk, with pro‐and/or prebiotics being especially promising. In this review, a synthesis of CRC prevention and treatment of strategies relying on usage of pro‐ and/or prebiotics supplements is given, as well as discuss mechanisms underlying the contribution of pro‐and/or prebiotics to the suppression of colonic carcinogenesis. Furthermore, a framework for personalizing such supplements according to the composition of an individual's gut microbiome is suggested. Various factors including diversity of one's intestinal microflora, integrity of their intestinal barrier, and the presence of mutagenic/carcinogenic/genotoxic and beneficial compounds are known to have a prominent influence on the development of CRC; thus, clarifying the role of pro‐ and/or prebiotics will yield valuable insight toward optimizing interventions for enhanced patient outcomes in the future.

Impact of storage on in vitro bioaccessibility of anthocyanins in ‘Rubycot’ plumcot and ‘Queen Garnet’ plum

“…Anthocyanin accumulation during postharvest storage is considered as an important quality attribute of dark red coloured plums, subsequently enhancing their bioactivity. (2) However, no significant (p > 0.05) differences were observed in relative anthocyanin bioaccessibility between the control and stored samples as well as between the two storage temperatures after in vitro digestion (RC: 1.8% (control), 0.1% (4°C) and 0.5% (23°C); QGP: 7.8% (control), 14.5% (4°C) and 12.3% (23°C)). In conclusion, these findings are important when considering the storage temperature and storage time to maintain, or even improve, the nutritional quality of RC and QGP.…”

Cellular and Molecular Mechanisms of the Colorectal Cancer Tumor Stroma: Insights into Disease Progression and Therapeutic Targets

“…Probiotics, live microorganisms conferring health benefits when administered in adequate amounts, may help restore immune homeostasis and reduce pro-inflammatory and pro-tumorigenic stimuli contributing to CRC progression [69,89,90]. Prebiotics, nondigestible food components that selectively stimulate the growth and activity of beneficial gut bacteria, promote the production of beneficial bacterial metabolites, such as SCFAs, potentially counteracting dysbiosis' adverse effects on colorectal tumor stroma development [91,92].…”

Cellular and Molecular Mechanisms of the Tumor Stroma in Colorectal Cancer: Insights into Disease Progression and Therapeutic Targets

“…Probiotics, live microorganisms conferring health benefits when administered in adequate amounts, may help restore immune homeostasis and reduce pro-inflammatory and pro-tumorigenic stimuli contributing to CRC progression [ 69 , 89 , 90 ]. Prebiotics, non-digestible food components that selectively stimulate the growth and activity of beneficial gut bacteria, promote the production of beneficial bacterial metabolites, such as SCFAs, potentially counteracting dysbiosis’ adverse effects on colorectal tumor stroma development [ 91 , 92 ].…”