Promoting bone regeneration by 3D-printed poly(glycolic acid)/hydroxyapatite composite scaffolds

Yeo, Taegyun; Ko, Young-Gwang; Kim, Eun Jin; Kwon, Oh Kyoung; Chung, Ho Yun; Kwon, Oh Hyeong

doi:10.1016/j.jiec.2020.11.004

Cited by 57 publications

(30 citation statements)

References 24 publications

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“…The PGA scaffold containing HAp nanoparticles was prepared by 3D printing technology, and the bone regeneration rate was 47% 8 weeks after surgery. Compared with the existing scaffolds, the porous PGA/HAp scaffold was implanted in the rabbit skull defect model, and the key defect area was covered by bone tissue, which indicates that the scaffold can promote the bone regeneration process [ 56 ]. Due to the nondegradability, good wear resistance, and low thermal conductivity of zirconia through 3D printing, it is widely used in ceramic abutments, implants, and crowns, as well as the femoral head part of hip prostheses in THA [ 57 ].…”

Section: Materials Of 3d Printingmentioning

confidence: 99%

Application and Development of Modern 3D Printing Technology in the Field of Orthopedics

Zhang

et al. 2022

BioMed Research International

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3D printing, also known as additive manufacturing, is a technology that uses a variety of adhesive materials such as powdered metal or plastic to construct objects based on digital models. Recently, 3D printing technology has been combined with digital medicine, materials science, cytology, and other multidisciplinary fields, especially in the field of orthopedic built-in objects. The development of advanced 3D printing materials continues to meet the needs of clinical precision medicine and customize the most suitable prosthesis for everyone to improve service life and satisfaction. This article introduces the development of 3D printing technology and different types of materials. We also discuss the shortcomings of 3D printing technology and the current challenges, including the poor bionics of 3D printing products, lack of ideal bioinks, product safety, and lack of market supervision. We also prospect the future development trends of 3D printing.

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Section: Materials Of 3d Printingmentioning

confidence: 99%

Application and Development of Modern 3D Printing Technology in the Field of Orthopedics

Zhang

et al. 2022

BioMed Research International

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“…Several studies have underlined the fragility of CaP scaffolds (which are highly porous), pointing them out as not suitable for weight-bearing bone defects. Therefore, in order to improve CaP mechanical and structural properties, different combinations have been attempted by adding other components with viscoelastic properties (tolerating high levels of strain or deformation and able to fill irregular-shaped bone defects) such as collagen [ 27 ], alginate [ 28 ], chitosan [ 29 , 30 ], polylactic acid (PLA) [ 31 ], and polyglycolic acid [ 32 ], giving rise to injectable hydrogel systems. They are typically biocompatible due to their large water content, and less prone to provoke an immune response [ 33 ].…”

Section: Strategies Promoting Bone Healing Through An Endogenous Responsementioning

confidence: 99%

Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

Macías

Alcorta-Sevillano

Infante

et al. 2021

IJMS

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Bone damage leading to bone loss can arise from a wide range of causes, including those intrinsic to individuals such as infections or diseases with metabolic (diabetes), genetic (osteogenesis imperfecta), and/or age-related (osteoporosis) etiology, or extrinsic ones coming from external insults such as trauma or surgery. Although bone tissue has an intrinsic capacity of self-repair, large bone defects often require anabolic treatments targeting bone formation process and/or bone grafts, aiming to restore bone loss. The current bone surrogates used for clinical purposes are autologous, allogeneic, or xenogeneic bone grafts, which although effective imply a number of limitations: the need to remove bone from another location in the case of autologous transplants and the possibility of an immune rejection when using allogeneic or xenogeneic grafts. To overcome these limitations, cutting edge therapies for skeletal regeneration of bone defects are currently under extensive research with promising results; such as those boosting endogenous bone regeneration, by the stimulation of host cells, or the ones driven exogenously with scaffolds, biomolecules, and mesenchymal stem cells as key players of bone healing process.

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“…Chen (2019) et al investigated the 3D printing of composite scaffolds composed of HA and gelatin, CS, and carboxymethyl cellulose (CMC) [ 81 ]. Yeo (2021) et al studied 3D-printed poly(glycolic acid)/HA composite scaffolds to promote bone regeneration [ 82 ]. The most important advantage of 3D-printed scaffolds is that 3D scaffolds can be used as tissue models to replicate the structural complexity of living tissues.…”

Section: Recent Strategies For Compounding Natural and Synthetic Poly...mentioning

confidence: 99%

Advances of Hydroxyapatite Hybrid Organic Composite Used as Drug or Protein Carriers for Biomedical Applications: A Review

et al. 2022

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Hydroxyapatite (HA), especially in the form of HA nanoparticles (HANPs), has excellent bioactivity, biodegradability, and osteoconductivity and therefore has been widely used as a template or additives for drug delivery in clinical applications, such as dentistry and orthopedic repair. Due to the atomically anisotropic distribution on the preferred growth of HA crystals, especially the nanoscale rod-/whisker-like morphology, HA can generally be a good candidate for carrying a variety of substances. HA is biocompatible and suitable for medical applications, but most drugs carried by HANPs have an initial burst release. In the adsorption mechanism of HA as a carrier, specific surface area, pore size, and porosity are important factors that mainly affect the adsorption and release amounts. At present, many studies have developed HA as a drug carrier with targeted effect, porous structure, and high porosity. This review mainly discusses the influence of HA structures as a carrier on the adsorption and release of active molecules. It then focuses on the benefits and effects of different types of polymer-HA composites to re-examine the proteins/drugs carry and release behavior and related potential clinical applications. This literature survey can be divided into three main parts: 1. interaction and adsorption mechanism of HA and drugs; 2. advantages and application fields of HA/organic composites; 3. loading and drug release behavior of multifunctional HA composites in different environments. This work also presents the latest development and future prospects of HA as a drug carrier.

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Promoting bone regeneration by 3D-printed poly(glycolic acid)/hydroxyapatite composite scaffolds

Cited by 57 publications

References 24 publications

Application and Development of Modern 3D Printing Technology in the Field of Orthopedics

Application and Development of Modern 3D Printing Technology in the Field of Orthopedics

Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration

Advances of Hydroxyapatite Hybrid Organic Composite Used as Drug or Protein Carriers for Biomedical Applications: A Review

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