Promoter polymorphisms in DNA repair gene ERCC5 and susceptibility to gastric cancer in Chinese

Duan, Zhipeng; He, Caiyun; Gong, Yantao; Li, Ping; Xu, Qian; Sun, Liping; Wang, Zhenning; Xing, Chengzhong; Yuan, Yuan

doi:10.1016/j.gene.2012.09.025

Cited by 31 publications

(46 citation statements)

References 30 publications

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“…A meta-analysis study with 23,490 cases and 27,168 controls indicated polymorphisms in XPG have role in various cancer risk, including skin cancer, breast cancer and smoking-related cancers (Zhu and Wang et al, 2012). In our study, we found rs2296147T>C and rs2094258C>T were associated with gastric cancer risk, and only one case-control study showed rs2296147C>T was associated with this cancer risk, and did not find association of other genotypes (Duan et al, 2012). The possible discrepancy of the results of XPG polymorphisms in gastric cancer may be due to different backgrounds of cases, sample size, sample size and etc.…”

Section: Discussioncontrasting

confidence: 57%

“…It is further involved in the stabilization of a pre-incision complex on the damaged DNA. It has only several studies reported the association of the SNPs of XPG and risk of cancers in Chinese population (Duan et al, 2012;Ma et al, 2012;Zhu and Shi et al, 2012). A study conducted in east China indicated rs2296147 CC was associated with decreased risk of esophageal cancer, of which was conducted among 1,115 squamous cell carcinoma cases and 1,117 cancer-free controls (Zhu and Shi, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…A study conducted in east China indicated rs2296147 CC was associated with decreased risk of esophageal cancer, of which was conducted among 1,115 squamous cell carcinoma cases and 1,117 cancer-free controls (Zhu and Shi, 2012). Another study included 403 cases and 403 health controls indicated rs751402 and rs2296147 polymorphisms might alter the risk of developing gastric cancer, and especially the diffuse subtype (Duan et al, 2012). A case-control study with 1059 cases and 1066 cancer free controls did not find a significant association with head and neck cancer risk (Ma et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

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SNPs of Excision Repair Cross Complementing Group 5 and Gastric Cancer Risk in Chinese Populations

Yang¹,

Zhang²,

Chen³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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We conducted a case-control study to determine the association between several potential SNPs of excision repair cross complementing group 5 (XPG) and gastric cancer susceptibility, and roles of XPG polymorphisms in combination with H.pylori infection in determining risk of gastric cancer. In our study, we collected 337 newly diagnosed gastric cancer cases and 347 health controls. Three SNPs of XPG, rs2296147T>C, rs2094258C>T and rs873601G>A, were genotyped using the Taqman real-time PCR method with a 7900 HT sequence detector system. H. pylori infection was diagnosed by ELISA. By multivariate logistic regression analysis, the rs2296147 CC genotype was associated with a decreased risk of gastric cancer (OR=0.52, 95% CI=0.27-0.97), and rs2094258 TT was associated with elevated risk (OR=2.13, 95% CI=1.22-3.35). Positive H.pylori individuals with rs2094258 TT genotypes demonstrated increased risk of gastric cancer (OR=2.13, 95% CI=1.22-3.35), while rs2296147 CC was associated with lower risk among patients with negative H.pylori (OR=0.45, 95%CI=0.22-0.89). Our findings suggested that XPG polymorphisms might contribute to risk of gastric cancer among Chinese populations, but the effect needs to be further validated by larger sample size studies.

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Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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SNPs of Excision Repair Cross Complementing Group 5 and Gastric Cancer Risk in Chinese Populations

Yang¹,

Zhang²,

Chen³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Previous studies have examined the association between ERCC5rs2094258 and rs751402 polymorphisms and the development of certain malignancies, including breast and gastric cancers, salivary gland tumors, and oral squamous cell carcinoma (Duan et al, 2012;Yang et al, 2012;Zavras et al, 2012;Meng et al, 2013;Na et al, 2015;Wang et al, 2015). For instance, Duan et al (2012) and Yang et al (2012) both reported that these polymorphisms contribute to the development of gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

“…To date, a small number of studies have examined the association between ERCC5 gene polymorphisms and gastric cancer risk, but their results have been inconclusive (Duan et al, 2012;Xue et al, 2015). Therefore, we conducted a case-control study to assess the association between ERCC5 promoter single nucleotide polymorphisms (SNPs; rs2094258 and rs751402) and development of gastric cancer in a Chinese population.…”

Section: Introductionmentioning

confidence: 99%

Lack of association between ERCC5 gene polymorphisms and gastric cancer risk in a Chinese population

et al. 2016

Genet. Mol. Res.

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ABSTRACT. We conducted a case-control study to assess the association between single nucleotide polymorphisms in the ERCC5 promoter (rs2094258 and rs751402) and development of gastric cancer in a Chinese population. This investigation included 184 patients with pathologically diagnosed gastric cancer and 206 healthy subjects recruited between October 2012 and December 2014. The genotyping of ERCC5 rs2094258 and rs751402 variants was performed by polymerase chain reaction coupled with restriction fragment length polymorphism. Genotype distributions of these polymorphisms conformed to HardyWeinberg equilibrium in both patient (P = 0.25 for rs2094258 and P = 0.61 for rs751402) and control groups (P = 0.48 for rs2094258 and P = 0.42 for rs751402). Using unconditional logistic regression analysis, we found that neither of these ERCC5 variants was associated with increased risk of gastric cancer under co-dominant, dominant, or recessive models (P < 0.05). In conclusion, we suggest that the rs2094258 and rs751402 polymorphisms are not connected to the development of this disease under codominant, dominant, and recessive models.

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An insight into clinical outcome of XPG polymorphisms in breast cancer

et al. 2018

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Promoter polymorphisms in DNA repair gene ERCC5 and susceptibility to gastric cancer in Chinese

Cited by 31 publications

References 30 publications

SNPs of Excision Repair Cross Complementing Group 5 and Gastric Cancer Risk in Chinese Populations

SNPs of Excision Repair Cross Complementing Group 5 and Gastric Cancer Risk in Chinese Populations

Lack of association between ERCC5 gene polymorphisms and gastric cancer risk in a Chinese population

An insight into clinical outcome of XPG polymorphisms in breast cancer

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