An insight into clinical outcome of XPG polymorphisms in breast cancer

Malik, Saima Shakil; Mubarik, Sumaira; Masood, Nosheen; Khadim, Muhammad Tahir

doi:10.1007/s11033-018-4401-7

Cited by 13 publications

(7 citation statements)

References 23 publications

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“…In Thailand, increased BCI in 1906–1935 might be due to the adoption of a westernized lifestyle and various sociodemographic and environmental risk factors. Early menarche and late menopause also contribute to increased BCI 12,30…”

Section: Discussionmentioning

confidence: 99%

“…Pakistan is the seventh most populated country in the world and faces an increased burden of breast cancer due to some demographic, economic, lifestyle, reproductive, and social issues. It is the most commonly diagnosed malignancy in Pakistan, and one-ninth women are facing this disease 11,12. Trend analysis suggests 98.6% increased cancer incidence among females,11 and younger women belonging to rural areas are more to develop hereditary breast cancer due to consanguinity resulting in poor disease prognosis 13.…”

Section: Introductionmentioning

confidence: 99%

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<p>Recent insights into breast cancer incidence trends among four Asian countries using age-period-cohort model</p>

Mubarik¹,

Malik²,

Wang³

et al. 2019

CMAR

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Purpose Breast cancer is one of the rapidly increasing cancers among women and a significant cause of cancer-related morbidity and mortality worldwide. Therefore, the current study was designed to examine and compare trends of breast cancer incidence (BCI) during the observed period (1990–2015) in specific age groups and investigate age-specific, time period, and birth cohort-related effects on BCI in China, India, Pakistan, and Thailand. Patients and method Data related to BCI were retrieved from the Institute for Health Metrics and Evaluation. Age–period–cohort model joint with intrinsic estimator algorithm was used to estimate the effect of age, period, and birth cohort on BCI. BCI rates were analyzed among different age groups ranging from 20 to 84 years in specified periods. Result Overall, results showed an increasing trend of BCI among four Asian countries during the study period especially in age groups 50 to 84 years. Higher incidence rates were observed in 2015 in the age group 70–74, 65–69, 50–54, and 60–64 in Pakistan, China, India, and Thailand, respectively. Age period cohort analysis revealed significantly raised effect of age and period and declined effect of the cohort on incidence rates. Conclusion The current study reported increased BCI with time in selected four Asian countries. Overall, BCI remained high in Pakistan as compared to China, India, and Thailand. Although proper registries are not available in most of the developing Asian countries, the current study highlighted the increased incidence and may play an essential role in registries development or spreading awareness against this disease. Therefore, maintaining proper records to build registries at the national level along with advancements in breast cancer screening and treatment are highly recommended to deal with the increasing burden of this disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>Recent insights into breast cancer incidence trends among four Asian countries using age-period-cohort model</p>

Mubarik¹,

Malik²,

Wang³

et al. 2019

CMAR

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“…Enzyme repair complementary complex 5 (ERCC5) is one of the key players for repairing platinum DNA adduct through the dual incision at both the 5’ and 3’ sides of the adduct which may lead to a decrease in platinum activity against cancer [ 30 ]. Hence, mutations in ERCC5 might enhance platinum effect on cancer cells.…”

Section: Discussionmentioning

confidence: 99%

“…Since the response to platinum-based regimens is variable therefore the need for identifying patients who would benefit more from chemotherapy is crucial. Enzyme repair complementary complex 5 (ERCC5) is one of the key players for repairing platinum DNA adduct through the dual incision at both the 5' and 3' sides of the adduct which may lead to a decrease in platinum activity against cancer [30]. Hence, mutations in ERCC5 might enhance platinum effect on cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Variants of ERCC5 and the outcome of platinum-based regimens in non-small cell lung cancer: a prospective cohort study

et al. 2022

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Excision repair complementary complex 5 (ERCC5) is an important component in the repair pathway of platinum-induced damage. The current study evaluated the effect of ERCC5 variants (rs751402 and rs1047768) on the clinical outcome of platinum-based regimens in non-small cell lung cancer (NSCLC) patients. A prospective, cohort study was conducted on 57 newly diagnosed NSCLC Egyptian patients. Patients received either cisplatin or carboplatin-based chemotherapy. DNA was extracted and the variants were analyzed using real time PCR. This study found no significant difference between the studied variants and patients’ response to chemotherapy, progression-free survival (PFS) or overall survival (OS). However, a statistically significant association was found between the histologic subtypes and the studied variants (p = 0.028 and 0.018 for rs751402 and rs1047768, respectively). A statistically significant association was evident between the type of the allele present in the studied polymorphisms, p value = 0.000040. Moreover, the minor allele frequency (MAF) of the studied variants rs751402 and rs1047768 were similar to those of African and European populations, respectively. Results of this study have concluded that ERCC5 variants did not affect the clinical outcome of platinum-based chemotherapy in NSCLC. A significant coinheritance was found between the two variants of ERCC5. Moreover, the similarity between the MAF of the studied variants and the African or European population can guide future research when extrapolating data from African European populations to their Egyptian counterparts.

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“…Breast cancer is the most commonly diagnosed cancer or disease among women all over the world and linked with considerable years of life lost, leading to increased cancer-related mortality and morbidity [1][2][3]. Breast cancer has multifactorial etiology and involves a complex interplay between genetic, epigenetic, and adjustable lifestyle or environmental factors [4].…”

Section: Introductionmentioning

confidence: 99%

A Hierarchical Age–Period–Cohort Analysis of Breast Cancer Mortality and Disability Adjusted Life Years (1990–2015) Attributable to Modified Risk Factors among Chinese Women

Mubarik

Wang

Malik

et al. 2020

IJERPH

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Limited studies quantified the age, period, and cohort effects attributable to different risk factors on mortality rates (MRs) and disability-adjusted life years (DALYs) due to breast cancer among Chinese women. We used data from the Global Burden of Disease Study (GBD) in 2017. Mixed-effect and hierarchical age–period–cohort (HAPC) models were used to assess explicit and implicit fluctuations in MRs and DALYs attributable to different breast cancer associated risk factors. As the only risk factor, high body mass index (HBMI) showed continuously increasing trends in MRs and DALYs across ages, periods, and cohorts. Age, recent periods (2010–2015), and risk factor HBMI showed significant positive effect on MRs and DALYs (p < 0.05). Moreover, we reported significant interaction effects of older age and period in recent years in addition to the interplay of older age and risk factor HBMI on MRs and DALYs. Increased age and obesity contribute to substantially raised breast cancer MRs and DALYs in China and around the globe. These discoveries shed light on protective health policies and provision of healthy lifestyle for improving the subsequent breast cancer morbidity and mortality for China, as well as other related Asian regions that are presently facing the same public health challenges.

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An insight into clinical outcome of XPG polymorphisms in breast cancer

Cited by 13 publications

References 23 publications

<p>Recent insights into breast cancer incidence trends among four Asian countries using age-period-cohort model</p>

<p>Recent insights into breast cancer incidence trends among four Asian countries using age-period-cohort model</p>

Variants of ERCC5 and the outcome of platinum-based regimens in non-small cell lung cancer: a prospective cohort study

A Hierarchical Age–Period–Cohort Analysis of Breast Cancer Mortality and Disability Adjusted Life Years (1990–2015) Attributable to Modified Risk Factors among Chinese Women

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