Promising Trial for Treatment of Chronic Myelogenous Leukemia Using Plasma Technology

Abstract

This article presents a trial of the treatment of chronic-phase (CP) and accelerated-phase (AP) chronic myelogenous leukemia (CML) that is resistant or only partially responded to chemotherapy. Blood samples of 6 cases diagnosed with CML were studied and compared with a control group. The first 3 cases were AP CML resistant to imatinib and nilotinib. The other 3 partially responded to the chemotherapy and returned to CP CML. Triple blood cultures for each case were exposed to a cold, pulsed, atmospheric pressure plasma jet for different durations (40, 80, and 120 seconds). Hematological, cytogenetic, and biochemical investigations were done before and after plasma jet exposure. The results showed an increase in necrotic and apoptotic cell counts and a decrease in the number of characteristic nucleoplasmic bridges (multinucleated threadlike shape). Concentrations of transforming growth factor-β1 and arginase decreased in the CML blood samples after exposure to plasma jet.This type of nonthermal plasma can kill cancer cells and prevent the cells from dividing, especially for the 80-second duration.

Redox‐regulation of activator protein 1 family members in blood cancer cell lines exposed to cold physical plasma‐treated medium

“…This is often due aberrancies in energy metabolism as they tend to employ glycolysis to generate energy (Warburg effect) . Thus, plasma provides an interesting opportunity to interfere with redox‐based processes in cancer cells by effectively inhibiting cell growth and inducing apoptosis, also in leukemic cells . Importantly, plasma‐treated solutions were shown to exhibit anticancer effects as well …”

Assessment of Cytogenetic Instability and Gene Transcription of Chronic Myelogenous Leukemia Cells Exposed to Non-thermal Plasma

“…In addition, the period time of 80 sec. was the most effective and save dose for attendant with the advice of Ahmed et al [59][60][61].…”

Another Concept of Cancer Interpretation in View of the Interaction between Plasma Radiation and DNA

“…[22][23][24][25] CAPPJ and gliding arc plasma exposure can be utilized to repair tissues, treat some diseases, and treat tumors, especially drug-resistant forms, according to evidence from several studies on various types of plasma and their effects on both healthy and malignant cells. [26,27] The most significant improvements in the halting of chromosomal instabilities were achieved by stimulation of several mitotic checkpoints, followed by apoptosis and necrosis processes, which were plasma's most effective roles. The same events were also found to increase immunological responses (interleukins and TNF-α) and the transcription of anti-tumor genes (P53, caspase-3, and Bcl2).…”