Promising Macromolecular Conjugates of Camptothecin - the Synthesis, Characterization and<i>in vitro</i>Studies

Sobczak, Marcin; Olędzka, Ewa; Kwietniewska, Magdalena; Nałęcz‐Jawecki, Grzegorz; Kołodziejski, Wacław

doi:10.1080/10601325.2014.871958

Cited by 8 publications

(11 citation statements)

References 27 publications

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“…In our previous paper [3] biodegradable conjugates of CMPT obtained from various copolymers were described. The copolymers were synthesized from ε-caprolactone (ε-CL), glycolide (GL), rac -lactide ( rac -LA) or trimethylene carbonate (TMC) and poly(ethylene glycol) (PEG).…”

Section: Resultsmentioning

confidence: 99%

“…CMPT-PLA conjugates were synthesized under an argon atmosphere using two-step process [3]. In the first step, PLA (1 g) was mixed with 1,4-diazabicyclo[2.2.2]octane (0.0025 g) and dissolved in CH 2 Cl 2 (20 mL).…”

Section: Methodsmentioning

confidence: 99%

“…These disadvantages could be overcome by attaching CMPT to a polymeric matrix. The polymeric conjugates of CMPT could act as a transport form for this drug and enhance its biodistribution [3]. In the past few years, CMPT has been covalently coupled to water-soluble polymers, i.e.…”

Section: Introductionmentioning

confidence: 99%

“…Although covalent conjugates of polylactide (PLA), a biodegradable and biocompatible polymer with a wide range of applications are known, PLA has not been applied for the synthesis of drug-PLA conjugates, which is due to its physicochemical properties; e.g., poly( l -lactide) (PLLA) is highly crystalline and degrades slowly [13,14]. In order to modify the drug release properties of PLA-based conjugates, PLA copolymers with poly(ε-caprolactone) (PCL), polyglycolide (PGL) and poly(trimethylenecarbonate) (PTMC) have been recently synthesized by us and used as polymeric matrices for the preparation of CMPT conjugates [3].…”

Section: Introductionmentioning

confidence: 99%

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Polylactide Conjugates of Camptothecin with Different Drug Release Abilities

et al. 2014

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Camptothecin-polylactide conjugates (CMPT-PLA) were synthesized by covalent incorporation of CMPT into PLA of different microstructure, i.e., atactic PLA and atactic-block-isotactically enriched PLA (Pm = 0.79) via urethane bonds. The kinetic release of CPMT from CMPT-PLA conjugates, tested in vitro under different conditions, is possible in both cases and notably, strongly dependent on PLA microstructure. It shows that release properties of drug-PLA conjugates can be tailored by controlled design of the PLA microstructure, and allow in the case of CMPT-PLA conjugates for the development of highly controlled biodegradable CMPT systems-important delivery systems for anti-cancer agents.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Polylactide Conjugates of Camptothecin with Different Drug Release Abilities

et al. 2014

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“…Biodegradable conjugates of camptothecin (CMPT), a terpenoid compound with strong anti‐tumour activity, obtained from different polyester copolymers from caprolactone, glycolide, lactide or trimethylene carbonate and PEG were also described . Polylactide is highly crystalline and degrades slowly, and these copolymers modify thus its drug release properties.…”

Section: Polyester Conjugation To Small Bioactive Moleculesmentioning

confidence: 99%

Covalent polyester-biomolecule conjugates: advances in their synthesis and applications in biomedicine and nanotechnology

Winnacker

2017

Polym. Int.

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Among the variety of polymeric biomaterials, polyesters have a significant position, for example due to their biocompatibility and (tunable) biodegradability. In addition to their established and 'pristine' use as, for example, implants or sutures, the introduction of specific functional biomolecules to polyesters has been attracting increasing attention within the past few years to afford polyester-based functional bioconjugates, which require certain synthesis strategies. Selected recent concepts for these covalent conjugations are summarized in this article in terms of the attachment of biological macromolecules as well as small bioactive drugs on polyesters.

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