Polyurethanes for controlled drug delivery

Basu, Arijit; Farah, Shady; Kunduru, Konda Reddy; Doppalapudi, Sindhu; Khan, Wahid; Domb, Abraham J.

doi:10.1016/b978-0-08-100614-6.00008-1

Cited by 29 publications

(17 citation statements)

References 107 publications

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“…This structure reveals unique and versatile physicochemical properties. In contrast to EVA, TPUs can be hydrophilic or hydrophobic depending on the chemical composition of their soft segments [ 48 , 50 ]. Hydrophilic TPUs tend to swell upon contact with water without degrading or dissolving, which impacts drug release kinetics [ 48 ].…”

Section: Introductionmentioning

confidence: 99%

Development of Porous Polyurethane Implants Manufactured via Hot-Melt Extrusion

et al. 2020

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Implantable drug delivery systems (IDDSs) offer good patient compliance and allow the controlled delivery of drugs over prolonged times. However, their application is limited due to the scarce material selection and the limited technological possibilities to achieve extended drug release. Porous structures are an alternative strategy that can overcome these shortcomings. The present work focuses on the development of porous IDDS based on hydrophilic (HPL) and hydrophobic (HPB) polyurethanes and chemical pore formers (PFs) manufactured by hot-melt extrusion. Different PF types and concentrations were investigated to gain a sound understanding in terms of extrudate density, porosity, compressive behavior, pore morphology and liquid uptake. Based on the rheological analyses, a stable extrusion process guaranteed porosities of up to 40% using NaHCO3 as PF. The average pore diameter was between 140 and 600 µm and was indirectly proportional to the concentration of PF. The liquid uptake of HPB was determined by the open pores, while for HPL both open and closed pores influenced the uptake. In summary, through the rational selection of the polymer type, the PF type and concentration, porous carrier systems can be produced continuously via extrusion, whose properties can be adapted to the respective application site.

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Section: Introductionmentioning

confidence: 99%

Development of Porous Polyurethane Implants Manufactured via Hot-Melt Extrusion

et al. 2020

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“…For areas where degradation should be tunable like drug delivery, PUs are usually developed in forms of electrospun networks [ 160 , 161 ], hydrogels [ 162 , 163 ], membranes [ 164 ] or nanocarriers like micelles [ 165 ] when quick drug release is needed. As PUs degradation process is mainly determined by the SS, degradation rates for tailored drug release time are obtained by varying the type and amount of polyols undergoing hydrolytic and enzymatic degradations such as polyesters-based polyols, to hydrophilic polyols undergoing water uptake and oxidative degradation like polyether-based polyols [ 166 , 167 ]. Tunable degradation for specific applications such as for example, cancer treatment was designed by incorporation of various stimuli-responsive bonds in the SS or HS of the PU architectures or molecules.…”

Section: Conventional (Fossil-based) Pu For Biomedical Applicationsmentioning

confidence: 99%

Biobased polyurethanes for biomedical applications

Wendels

Avérous

2021

Bioactive Materials

232

173

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Polyurethanes (PUs) are a major family of polymers displaying a wide spectrum of physico-chemical, mechanical and structural properties for a large range of fields. They have shown suitable for biomedical applications and are used in this domain since decades. The current variety of biomass available has extended the diversity of starting materials for the elaboration of new biobased macromolecular architectures, allowing the development of biobased PUs with advanced properties such as controlled biotic and abiotic degradation. In this frame, new tunable biomedical devices have been successfully designed. PU structures with precise tissue biomimicking can be obtained and are adequate for adhesion, proliferation and differentiation of many cell's types. Moreover, new smart shape-memory PUs with adjustable shape-recovery properties have demonstrated promising results for biomedical applications such as wound healing. The fossil-based starting materials substitution for biomedical implants is slowly improving, nonetheless better renewable contents need to be achieved for most PUs to obtain biobased certifications. After a presentation of some PU generalities and an understanding of a biomaterial structure-biocompatibility relationship, recent developments of biobased PUs for non-implantable devices as well as short- and long-term implants are described in detail in this review and compared to more conventional PU structures.

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“…Biodegradable by hydrolysis 45 , good mechanical properties 46 and solubility in organic solvents 47 , reinforce hydrogels 48,49 hydrolysis by-products can cause inflammation 44 occur. Addition of N-hydroxysuccinimide (NHS) allows for more stable esters compared to O-acylisourea intermediate and more reactive towards amines 62 .…”

Section: Poly(lactic Acid) and Copolymersmentioning

confidence: 99%