Promising Antidiabetic Drugs, Medicinal Plants and Herbs: An Update

Yatoo, Mohd Iqbal; Saxena, Archana; Gopalakris, Arumugam; Alagawany, Mahmoud; Dhama, Kuldeep

doi:10.3923/ijp.2017.732.745

Cited by 36 publications

(22 citation statements)

References 88 publications

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“…Various mechanisms have been proposed for the antidiabetic and hypoglycemic activities of medicinal plants. These include peripheral utilization of glucose, increased synthesis of hepatic glycogen by enhancement of glycogen regulatory enzyme expression in the liver, inhibition of carbohydrate metabolizing enzymes, stimulation of pancreatic insulin release, insulomimetic actions and inhibition of hepatic glucose production [55,56].…”

Section: Mechanism Of Actionmentioning

confidence: 99%

A Review of the Antidiabetic Activities of Ginger

Otunola¹,

Afolayan²

2020

Ginger Cultivation and Its Antimicrobial and Pharmacological Potentials

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Diabetes mellitus, a chronic metabolic disorder with major health care burden worldwide, is increasing, with 173 million adults being diabetic and over 8 million deaths recorded annually. Undesirable pathological conditions and high rates of secondary failure limit the use of current antidiabetic agents, thus, the need for more effective antidiabetic agents. Medicinal plants such as spices, rich in bioactive components that promote prevention and treatment of chronic conditions such as heart disease, cancer and Type-2 diabetes, are inexpensive with no side effects. The Zingiberaceae family, of which ginger is a member, consists of many species frequently cited for their antidiabetic and hypoglycemic properties. All important scientific literatures from 2000 to 2018 on the antidiabetic potentials of Zingiber officinale were evaluated. According to these studies, ginger exerts its antidiabetic effects through restorative effects on pancreatic β-cells, increasing insulin sensitivity, action and peripheral utilization of glucose. Other mechanisms include increased synthesis of hepatic glycogen through the enhancement of glycogen regulatory enzyme expression in the liver, inhibition of carbohydrate metabolizing enzymes, stimulation of pancreatic insulin release and inhibition of hepatic glucose production. Further studies, especially in humans are needed, more so, since ginger is one of the spices generally regarded as safe.

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Section: Mechanism Of Actionmentioning

confidence: 99%

A Review of the Antidiabetic Activities of Ginger

Otunola¹,

Afolayan²

2020

Ginger Cultivation and Its Antimicrobial and Pharmacological Potentials

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“…In Addition, diabetes is a fast growing potential epidemic syndrome in India with more than 62 million diabetic patients currently diagnosed every year. It is assumed that by the year 2030 such cases may increase up to 79.4 million, posing potential risk imposed by diabetes 2 .A vast number of herbal plants with potential antidiabetic activity have been studied, which may include: Azadirachta indica (leaves, stem bark and seeds) possess hypoglycemic activity via increasing insulin secretion from pancreatic beta-cells, Grewia asiatica (its antioxidant and radical scavenging activity), Eugenia jambolana (seed kernel extracts) inhibits alphaglucosidase activity, Cinamomum zeylanicum (chief active constituent cinnamaldehyde) increases serum insulin level, Allium sativum (active compound allicin) shows significant hypoglycemic activity, Allium cepa (active constituent S-methyl cysteine sulphoxide) significantly controls blood glucose levels and others like Aegle mermelos, Aralia elata, Phyllanthus amarus and Tinospora cordifolia 3 . Recently, the World Health Organization (WHO) suggested the use of medicinal plants for the management of Diabetes Mellitus and further encouraged the expansion of the frontiers of scientific evaluation of anti-diabetic properties of diverse plant species.…”

Section: Introductionmentioning

confidence: 99%

Anti-Diabetic Effects of Some Medicinal Plants in Experimental Animals: A Review

Maqbool¹,

Gani²,

Dar³

2019

Asian J Pharm Res Dev

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Diabetes is a chronic endocrine disease with global prevalence and increasing incidence. Diabetes presents with a major health issue in all age groups in the present times owing to its multisystem involvement and serious complications. In spite of drug development and therapeutic interventions, successful treatment of diabetes still remains a challenge and worldwide research is focused on finding alternative modalities. By conducting sizable amount of analytical work, numerous traditional medicines have been found for diabetes. Substances and extracts isolated from completely different natural resources particularly plants have perpetually been a fashionable arsenal for dominant and treating polygenic disorders downside and complication arising because of it. Many medicinal plants have shown promising effects in experimental animals which can be extrapolated to humans also. In this paper, we will review various medicinal plants showing anti-diabetic activity in experimental animals.

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“…Medicinal plants have been popular since ancient times because of their fewer toxic and side effects, widespread availability and relatively low costs (3). A number of medicinal plants have been used extensively in treatment of diabetes mellitus (4,5). Anti-hyperglycemic activities of Myrtus communis oil in type-2 diabetic patients (6), hypolipidemic effects of Trachyspermum copticum seeds in patients with primary hyperlipidemia (7) and effects of Ferula gummosa species in treatment of diabetes (8) have already been shown in a few studies.…”

Section: Introductionmentioning

confidence: 99%

“…However, specific ingredients of most herbs with therapeutic effects are not well defined (9). Findings of several medicinal plant studies have shown that phenolics, alkaloids, terpenoids, flavonoids, carotenoids, tannins and saponins are the most substantial phytoconstituents with antidiabetic effects which have been used empirically in antidiabetic and antihyperlipidemic remedies (5,10,11).…”

Section: Introductionmentioning

confidence: 99%

“…Medicinal plants may reduce blood glucose due to their ability to restore the function of pancreatic tissues and increase insulin output, inhibit intestinal glucose uptake or modulate inflammatory and oxidative stress-dependent pathways which show critical roles in pathogenesis of diabetes (11). Various constituents of antidiabetic medicinal plants improve glucose metabolism and lipid profiles in diabetic animals through various mechanisms including antioxidant, immunomodulatory and hepatopancreatic protective mechanism (5).Demonstrating antidiabetic and antihyperlipidemic effects of medicinal plants in stablished animal models of diabetes and further pharmaceutical mechanism studies are necessary. Antioxidant, anti-atherosclerosis and hepatoprotective effects of M. communis extracts have been demonstrated in STZ-induced diabetes rats (12,13).…”

Section: Introductionmentioning

confidence: 99%

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Hypoglycemic and Hypolipidemic Effects of Myrtus communis, Trachyspermum copticum and Ferula gummosa Essential Oils on Streptozotocin Induced Diabetic Rats

et al. 2019

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Background and Objectives: Diabetes is one of the major health challenges in world. Herbal medicines are widely used for the treatment of diabetes. The current study assessed the effects of oral administration of essential oils from Myrtus communis, Trachyspermum copticum and Ferula gummosa on blood glucose and lipid profiles in streptozotocininduced diabetic rats and inhibitory effects of these oils on α-glucosidase activity in vitro. Materials and Methods: Forty-eight male Wistar rats were divided into six groups of healthy control, diabetic control, healthy control received corn oil and three experimental diabetic groups treated by the essential oils. Four weeks after intraperitoneal injections of 45-mg/kg streptozotocin doses, experimental groups were gavaged with 200 mg/kg/day of the oils for thirty days, then serum glucose and lipid profiles of the rats were assessed. Data were analyzed using one-way ANOVA and Tukey test. Study was carried out in Animal Laboratory of the

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Promising Antidiabetic Drugs, Medicinal Plants and Herbs: An Update

Cited by 36 publications

References 88 publications

A Review of the Antidiabetic Activities of Ginger

A Review of the Antidiabetic Activities of Ginger

Anti-Diabetic Effects of Some Medicinal Plants in Experimental Animals: A Review

Hypoglycemic and Hypolipidemic Effects of Myrtus communis, Trachyspermum copticum and Ferula gummosa Essential Oils on Streptozotocin Induced Diabetic Rats

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