Promising anti‐tumor properties of bisdemethoxycurcumin: A naturally occurring curcumin analogue

Ramezani, Mohammad; Hatamipour, Mahdi; Sahebkar, Amirhosein

doi:10.1002/jcp.25795

Cited by 59 publications

(32 citation statements)

References 97 publications

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“…DMC has also shown ability to inhibit the growth of prostate cancer cells [32]. Furthermore, BDMC, the minor constitute, has shown the highest stability compared to the other two curcuminoids and was found to inhibit tumor growth in various cell lines such as HeLa and ovarian cancer cells [33,41,42]. In the present study, the three members of curcuminoids jointly exhibited a toxic effect against SKOV-3 cells with an IC 50 of 30 µM.…”

Section: Discussionmentioning

confidence: 60%

Cytotoxicity of Standardized Curcuminoids Mixture against Epithelial Ovarian Cancer Cell Line SKOV-3

et al. 2020

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Herbal medicine has been in use for centuries for a wide variety of ailments; however, the efficacy of its therapeutic agents in modern medicine is currently being studied. Curcuminoids are an example of natural agents, widely used due to their potential contribution in the prevention and treatment of cancer. In this study, the three main compounds of curcuminoids-curcumin, desmethoxycurcumin, and bisdesmethoxycurcumin-were determined by reversed-phase high performance liquid chromatography (HPLC) to quantify total content in a mixture. Subsequently, the effect of the three curcuminoids, employed as one sample, was evaluated, to study the proliferation, apoptosis, cell cycle, and migration of the human ovarian cancer cell line SKOV-3. The results reveal that curcuminoids inhibit the proliferation of SKOV-3 cells with concentration-and time-dependent mechanisms. The morphological analysis of the treated SKOV-3 cells showed a typical apoptotic phenotype-cell shrinkage and membrane blebbing in a dose-dependent manner. In addition, flow cytometry demonstrated an increase in apoptosis with an IC 50 of 30 µM curcuminoids. The migration of SKOV-3 cells was also inhibited, reflected by a decrease in wound area. Furthermore, the curcuminoids were found to have no stimulation effect on the expression of cytokines TNF-α and IL-10. These results suggest that a curcuminoid mixture can effectively suppress epithelial cancer cell growth in vitro by inducing cellular changes and apoptosis.

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Section: Discussionmentioning

confidence: 60%

Cytotoxicity of Standardized Curcuminoids Mixture against Epithelial Ovarian Cancer Cell Line SKOV-3

et al. 2020

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“…Mahin Ramezani et al mentioned that BDMC, a natural analogue, present in the rhizome Curcuma longa along with Curcumin, also possess antitumour activity. This compound has shown more effective anticancer activity than Curcumin in almost all type of cancers through different pathways [123]. Apoptotic effect of BDMC is induced by reducing the levels of heme oxygenase-1, BCL-2 (an anti-apoptotic protein).…”

Section: Fig 10: Preparation Of Phospholipid Vesicle For the Delivermentioning

confidence: 99%

Curcumin, a Natural Golden Drug and Its Anticancer Aspects From Synthesis to Delivery: A Review

2020

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Cancer is a dreadful disease and, in most cases, leads to death even when it is being treated. Even though synthetic drugs are still in use for the treatment of cancer, the seriousness of the side effects of these drugs has boggled researcher’s mind to find more effective drugs which will help to overcome the side effects and have greater potency in trying to make the patient completely free of the disease. Recently, researchers turned their attention towards bio-components present in natural products. Curcumin, a polyphenol and the main constituent of a rhizome Curcuma longa, has geared significant interest due to its wide spectrum of therapeutics values, especially anticancer activity. Paper summarizes the chemistry and bio-metabolism of curcumin in the human body. Aim of this review article is to gather the dispersed efforts of researchers predominantly in improving the bioavailability of curcumin. In the present review, comprehensive literature on anticancer activity of Curcumin via combination therapy, structure modification, synthesis of analogues, novel delivery systems have been highlighted. Besides, the review paper explicated several challenges associated with Curcumin as an adjuvant chemotherapeutic agent and emphasizes more on clinical studies.

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“…Curcumin (diferuloylmethane) is a polyphenolic component of Curcuma longa , which is commonly accompanied by related structures such as demethoxycurcumina nd bsdemethoycurcumin, generally known as curcuminoids (Figure ). It has been shown that curcumin possesses anticancer (Mirzaei et al, ; Momtazi et al, ; Ramezani, Hatamipour, & Sahebkar, ; Teymouri, Pirro, Johnston, & Sahebkar, ), antioxidant (Panahi, Alishiri, Parvin, & Sahebkar, ; Panahi, Khalili, et al, ; Sahebkar et al, ; Sahebkar, Serban, Ursoniu, & Banachm, ), anti‐inflammatory (Ghandadi & Sahebkar, ; Panahi et al, ; Panahi, Sahebkar, Parvin, & Saadat, ; Sahebkar, ), immunomodulatory (Abdollahi, Momtazi, Johnston, & Sahebkar, ; Ganjali et al, ; Karimian, Pirro, Majeed, & Sahebkar, ; Sahebkar, Cicero, Simental‐Mendía, Aggarwal, & Gupta, ), hepatoprotective (Panahi, Kianpour, et al, ; Rahmani et al, ; Zabihi, Pirro, Johnston, & Sahebkar, ), lipid‐regulating (Ganjali et al, ; Mohammadi et al, ; Panahi, Ahmadi, Teymouri, Johnston, & Sahebkar, ; Panahi, Khalili, Hosseini, Abbasinazari, & Sahebkar, ; Panahi et al, ; Sahebkar, ), antidepressant (Esmaily et al, ; Panahi, Badeli, Karami, & Sahebkar, ), anti‐arthritis (Panahi et al, ; Sahebkar & Henrotin, ) and pulmonoprotective (Lelli, Sahebkar, Johnston, & Pedone, ; Panahi, Ghanei, Hajhashemi, & Sahebkar, ) actions. Curcumin has also been shown to have chemoprotective, chemopreventive, and immuno‐modulating properties (Cole et al, ; Donatus & Vermeulen, ).…”

Section: Curcumin As a Potential Agent In Cardiovascular Diseasementioning

confidence: 99%

Curcumin, hemostasis, thrombosis, and coagulation

Keihanian

Saeidinia

Bagheri

et al. 2017

Journal Cellular Physiology

142

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Atherothrombotic cardiovascular disease is a major cause of mortality throughout the world. Platelet activation and aggregation play a central role in hemostasis and thrombosis. Herbal medicines have been traditionally used in the management of cardiovascular disease and can help in modifying its progression, particularly in hemostasis and the coagulation process, as well as altering platelet function tests and some coagulation parameters. Curcumin is a polyphenol derived from the Curcuma longa plant and has been used extensively in complementary and alternative medicine, as it is nontoxic and safe with various therapeutic properties. Modern scientific research has demonstrated its anti-inflammatory, antioxidant, anti-carcinogenic, antithrombotic, and cardiovascular protective effects. The present study reviewed previous studies in the literature, which support the positive activity of curcumin in hemostasis, anticoagulation, and fibrinolysis. We also presented molecular mechanisms associated with the antiplatelet and anticoagulant activities of curcumin and potential implications for the treatment of cardiovascular disease.

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Promising anti‐tumor properties of bisdemethoxycurcumin: A naturally occurring curcumin analogue

Cited by 59 publications

References 97 publications

Cytotoxicity of Standardized Curcuminoids Mixture against Epithelial Ovarian Cancer Cell Line SKOV-3

Cytotoxicity of Standardized Curcuminoids Mixture against Epithelial Ovarian Cancer Cell Line SKOV-3

Curcumin, a Natural Golden Drug and Its Anticancer Aspects From Synthesis to Delivery: A Review

Curcumin, hemostasis, thrombosis, and coagulation

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