Prominent B-Cell Signature Differentiates Discoid from Subacute Cutaneous Lupus Erythematosus

Lerman, Irina; Bawany, Fatima; Whitt, Wade; Esaa, Fatema; Yon, Joshuah; Babkowski, N.; Rapp, M.B.; Scott, Glynis; Anolik, Jennifer H.; Richardson, Christopher T.

doi:10.1016/j.jid.2022.03.033

Cited by 9 publications

(1 citation statement)

References 41 publications

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“…These cells include neurons ( MAP2 ; Chen M.L. et al, 2021 and TBR1 ; Yook et al, 2019 ), astrocytes ( GFAP ; Wang et al, 2020 and ALDOC ; Zeisel et al, 2015 ), microglia ( HEXB8 ; Sousa et al, 2018 ), oligodendrocytes ( PLP1 ; Marques et al, 2016 ), oligodendrocyte precursor cells ( PDGFRA ; Alessandrini et al, 2020 ), endothelial cells ( ITM2A ; Cegarra et al, 2022 ), pericytes (Desmin and PDGFR-β ; Smyth et al, 2018 ), macrophages ( CD163 ; Skytthe et al, 2020 ), B cells ( MS4A1 and CD79A ; Lerman et al, 2022 ), T cells ( CD3 , CD4 , CD5 , CD8 ; Martinez-Lage et al, 2019 ), monocytes ( CD14 and CD16 ; Calderon et al, 2017 ), ependymal cells ( TTR ; Gokce et al, 2016 ), and fibroblasts ( COL1A1 ; Bonney et al, 2022 ). Among them, most cells were microglia, astrocytes, and oligodendrocytes.…”

Section: Brain Cellular Damagementioning

confidence: 99%

Post-ischemic inflammatory response in the brain: Targeting immune cell in ischemic stroke therapy

Shen

Shao

et al. 2023

Front. Mol. Neurosci.

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An ischemic stroke occurs when the blood supply is obstructed to the vascular basin, causing the death of nerve cells and forming the ischemic core. Subsequently, the brain enters the stage of reconstruction and repair. The whole process includes cellular brain damage, inflammatory reaction, blood–brain barrier destruction, and nerve repair. During this process, the proportion and function of neurons, immune cells, glial cells, endothelial cells, and other cells change. Identifying potential differences in gene expression between cell types or heterogeneity between cells of the same type helps to understand the cellular changes that occur in the brain and the context of disease. The recent emergence of single-cell sequencing technology has promoted the exploration of single-cell diversity and the elucidation of the molecular mechanism of ischemic stroke, thus providing new ideas and directions for the diagnosis and clinical treatment of ischemic stroke.

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