Prolymphozytäre Leukämie

Abstract

Prolymphocytic leukaemia occurred in two women aged 75 and 57 years, respectively. In both instances the lymphatic cells fulfilled the morphological criteria of the disease picture. In one patient the disease was characterised by immunological and physical methods as being a B-cell lymphoma, in the other a T-cell lymphoma. Acid phosphatase was of special significance among cytochemical studies. While the patient with the T-cell lymphoma died after three months, the one with B-cell lymphoma is still alive 16 months later. Splenectomy resulted in marked improvement in the latter patient's condition and may turn out to be the treatment of choice in prolymphocytic leukaemia.

B‐Prolymphocytic Leukaemia ‐ A Mantle Zone Lymphoma?

“…In total, 6 cases of T-PL (Catovsky et a1 1973, Brouet et a1 1975, Loffler et al 1977, Lennert et al 1978, Abbrederis et a1 1979 and 16 cases of B-PL (Catovsky et a1 1973, Buskard et a1 1976, Catovsky 1977, Lennert et a1 1978, Abbrederis et al 1979 have been reported. In total, 6 cases of T-PL (Catovsky et a1 1973, Brouet et a1 1975, Loffler et al 1977, Lennert et al 1978, Abbrederis et a1 1979 and 16 cases of B-PL (Catovsky et a1 1973, Buskard et a1 1976, Catovsky 1977, Lennert et a1 1978, Abbrederis et al 1979 have been reported.…”

Efficacy of Doxorubicin in Prolymphocytic Leukaemia

“…Following the review by Galton et al (1974) prolymphocytic leukaemia has been a well recognized lymphoproliferative disorder though only a few well-documented cases have been published (Catovsky et al, 1973;Brouet et al, 1976;Buskard et al, 1976;Prakask & Aurora, 1976;Catovsky, 1977;Cavalli et al, 1977;Loffler et al, 1977;Thiel et al, 1977;Huhn et al, 1978;Singh et al, 1978;Abbrederis et al, 1979). This rare variant of chronic lymphocytic leukaemia (CLL) is considered to have a much poorer prognosis than classical CLL.…”

“…This rare variant of chronic lymphocytic leukaemia (CLL) is considered to have a much poorer prognosis than classical CLL. Splenectomy as proposed by Galton et al(1974) and/or leucapheresis seem to confer some benefit (Prakask & Aurora, 1976;Buskard et al, 1976;Abbrederis et al, 1979) whereas chemotherapy with drugs which are usually effective in CLL, particularly alkylating agents and corticosteroids, has been said to be notoriously ineffective.…”