B‐Prolymphocytic Leukaemia ‐ A Mantle Zone Lymphoma?

Abstract

A case of prolymphocytic lymphomdleukaemia (PL) sensu Galton in a 32-year-old man is presented. The leucocyte count was 19.0 x 1@/1 at presentation and tartrate resistent acid phosphatase was present in most prolymphocytes. Immunological investigation of prolymphocytes from lymph nodes, spleen and peripheral blood r e vealed the surface marker phenotype: SmIg+ ( p , (a), A), IgG-Fc-receptor+, C3-receptor+. The prolymphocytes from lymph nodes and spleen were C3-receptor+ in a high percentage, while only a few were IgG-Fc-receptor+. This proportion was reversed in the blood prolymphocytes. The histology of lymph nodes was unique and strongly suggested a preferential involvement (homing phenomenon) of the mantle zone of the lymphatic follicle. These results may indicate that emission of prolymphocytes from lymph nodes to circulation involves a change of surface receptors. It is finally suggested to consider the diagnosis of not only hairy-cell leukaemia but also PL in the case of tartrate resistent acid phosphatase-positive lymphoma/ leukaemia.

Immunophenotyping of mature B-cell non Hodgkin lymphoma involving bone marrow and peripheral blood: critical analysis and insights gained at a tertiary care cancer hospital

“…In the study conducted by Kaleem et al, 10% of CLL cases showed other CD5/CD23 phenotypes, out of which 7% showed CD5þ/CD237 pattern [14]. Frequency of CD23 negativity in CLL is very low and support the hypothesis that most cases reported as CLL with CD23 negativity were actually leukemic phase of NHL [15], commonly MCL [16,17]. In some patients, it may be difficult to distinguish between CLL and MCL on FCM and these cases might need a LN biopsy for confirmation.…”