Prolymphocytic Leukemia with T Cell Properties and Tartrate Resistant Acid Phosphatase

Löffler, Helmut; Graubner, M.; Desaga, J. F.; Jung, M

doi:10.1007/978-3-642-66639-1_20

Cited by 20 publications

(7 citation statements)

References 8 publications

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“…These results seem to indicate that T-rAcP is observed in well-differentiated lymphoid cells except the most highly differentiated forms of B-cells of macroglobulinemia and MM. Recent reports of the existence of T-rAcP activity in the neoplastic cells from the patients with prolymphocytic leukemia [19], B-CLL [20], and Sezary syndrome (211 may be compatible with our results.…”

Section: Discussionsupporting

confidence: 93%

Existence of tartrate‐resistant acid phosphatase activity in differentiated lymphoid leukemic cells

et al. 1982

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Acid phosphatase (AcP) in neoplastic cells from various lymphoid leukemias was examined. In the cytochemical studies, tartrate-resistant AcP (T-rAcP) activity was observed in the neoplastic cells from well-differentiated lymphoid leukemias such as adult T-cell leukemia (ATL), B-cell chronic lymphocytic leukemia (B-CLL), T-cell chronic lymphocytic leukemia (T-CLL), and hairy-cell leukemia (HCL). T-rAcP activity was also detected in a small number of leukemic cells obtained from T-cell acute lymphoblastic leukemia (T-ALL), while it was not detected in the neoplastic cells from null-ALL, macroglobulinemia, and multiple myeloma (MM). In the electrophoretical studies, fraction 1 (F-1), F-3, F-3b, and F-4 were completely tartrate-sensitive, while F-2 was partially resistant and F-5 was completely resistant. T-rAcP activity (F-5) was observed in ATL cells, B-CLL cells, and HCL cells, while it was not detected in ALL cells, macroglobulinemia cells, and MM cells. The present study indicates that T-rAcP activity is observed not only in HCL cells but also in the well-differentiated lymphoid cells such as ATL cells, B-CLL and T-CLL cells except the most highly differentiated forms of B-cells of MM and macroglobulinemia.

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Section: Discussionsupporting

confidence: 93%

Existence of tartrate‐resistant acid phosphatase activity in differentiated lymphoid leukemic cells

et al. 1982

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“…These varying results are in accordance with findings of other authors [3,6,14] who observed typical cases of PL with either B-or T-ceU characteristics. These varying results are in accordance with findings of other authors [3,6,14] who observed typical cases of PL with either B-or T-ceU characteristics.…”

Section: Discussionsupporting

confidence: 93%

“…PL can be delimitated from CLL, from ALL, and from lymphosarcoma cell leukemia mainly on the grounds of typical clinical (greatly enlarged spleen) and hematological (very high leukocyte counts and peculiar morphology of leukemic cells) findings. PL, as described by Galton [5,6] and confirmed by other authors [4,11,14], appears to be quite rare. In PL, the response to treatment usually effective in classical CLL or ALL is almost uniformly poor, the survival time is in the range of several months and only few patients survive for more than one year after diagnosis [6].…”

Section: Discussionsupporting

confidence: 64%

Prolymphocytic leukemia

Huhn

Thiel²,

Rodt³

et al. 1978

Klin Wochenschr

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“…In total, 6 cases of T-PL (Catovsky et a1 1973, Brouet et a1 1975, Loffler et al 1977, Lennert et al 1978, Abbrederis et a1 1979 and 16 cases of B-PL (Catovsky et a1 1973, Buskard et a1 1976, Catovsky 1977, Lennert et a1 1978, Abbrederis et al 1979 have been reported. In total, 6 cases of T-PL (Catovsky et a1 1973, Brouet et a1 1975, Loffler et al 1977, Lennert et al 1978, Abbrederis et a1 1979 and 16 cases of B-PL (Catovsky et a1 1973, Buskard et a1 1976, Catovsky 1977, Lennert et a1 1978, Abbrederis et al 1979 have been reported.…”

Section: Discussionmentioning

confidence: 99%

B‐Prolymphocytic Leukaemia ‐ A Mantle Zone Lymphoma?

Pallesen

Madsen

Pedersen

1979

Scandinavian Journal of Haematology

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A case of prolymphocytic lymphomdleukaemia (PL) sensu Galton in a 32-year-old man is presented. The leucocyte count was 19.0 x 1@/1 at presentation and tartrate resistent acid phosphatase was present in most prolymphocytes. Immunological investigation of prolymphocytes from lymph nodes, spleen and peripheral blood r e vealed the surface marker phenotype: SmIg+ ( p , (a), A), IgG-Fc-receptor+, C3-receptor+. The prolymphocytes from lymph nodes and spleen were C3-receptor+ in a high percentage, while only a few were IgG-Fc-receptor+. This proportion was reversed in the blood prolymphocytes. The histology of lymph nodes was unique and strongly suggested a preferential involvement (homing phenomenon) of the mantle zone of the lymphatic follicle. These results may indicate that emission of prolymphocytes from lymph nodes to circulation involves a change of surface receptors. It is finally suggested to consider the diagnosis of not only hairy-cell leukaemia but also PL in the case of tartrate resistent acid phosphatase-positive lymphoma/ leukaemia.

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Prolymphocytic Leukemia with T Cell Properties and Tartrate Resistant Acid Phosphatase

Cited by 20 publications

References 8 publications

Existence of tartrate‐resistant acid phosphatase activity in differentiated lymphoid leukemic cells

Existence of tartrate‐resistant acid phosphatase activity in differentiated lymphoid leukemic cells

Prolymphocytic leukemia

B‐Prolymphocytic Leukaemia ‐ A Mantle Zone Lymphoma?

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