Prolonged Targeting of Ischemic/Reperfused Myocardium by Liposomal Adenosine Augments Cardioprotection in Rats

Abstract

An infusion as PEGylated liposomes augmented the cardioprotective effects of adenosine against ischemia/reperfusion injury and reduced its unfavorable hemodynamic effects. Liposomes are promising for developing new treatments for acute MI.

From bench to bedside: Seeing the future of ischaemic post-conditioning as a novel cardioprotective therapy

“…(30) Ischaemic post-conditioning in reperfusion following PCI (31) Ischaemic post-conditioning in reperfusion following emergency PCI (52) Retrospective trial comparing patients with balloon inflations in emergency PCI (34) Ischaemic post-conditioning in reperfusion following PCI (33) Ischaemic post-conditioning during cold cardioplegic arrest in valve surgery (35) Infarct size However, recent experimental studies using polyethylene glycol liposomal adenosine in rats protected against ischaemia-reperfusion and reduced the haemodynamic effect of adenosine. (47) If this protocol can be applied in a clinical setting, it may limit the side effects of adenosine.…”

Cardiac Protection with Targeted Drug Delivery to Ischemic-Reperfused Myocardium

“…Important results were obtained in a landmark study by Takahama et al (2009) who used liposomal adenosine for treatment of myocardial ischemia-reperfusion in rats. Adenosineloaded liposomes were infused intravenously for 10 minutes starting 5 minutes prior to myocardial reperfusion.…”

“…For example, intravenous administration of adenosine is associated with arterial hypotension and bradycardia (Takahama et al, 2009), while administration of bradykinin might lead to hypotension and bronchial spasm (Homma & Irvin, 1999). It follows, therefore, that targeted delivery of preconditioning mimetics or synthetic agonists of G-protein-coupled receptors might contribute to improved safety and efficacy profile of these compounds, especially taking into account the encouraging results with heart-targeted delivery of adenosine (Takahama et al, 2009). Table 3.…”

Cardiac Postconditioning: An Additional Therapy to Limit Cell Death Following Myocardial Infarction

“…However, recent experimental studies using polyethylene glycol liposomal adenosine in rats protected against ischemia-reperfusion and reduced the hemodynamic effect of adenosine. (Takahama et al 2009) If this protocol can be applied in a clinical setting, it may limit the side effects of adenosine.…”