Prolonged subcutaneous delivery of low molecular weight heparin based on thermoresponsive hydrogels with chitosan nanocomplexes: Design, in vitro evaluation, and cytotoxicity studies

Poly(vinyl alcohol)/chitosan/honey/clay responsive nanocomposite hydrogel wound dressing

“…Chen et al . and Matanovic et al . also reported the precipitation of chitosan chains and dissociation of hydrogel network at pH = 7.4…”

Multi-component hybrid hydrogels – understanding the extent of orthogonal assembly and its impact on controlled release

“… 9 There is interest in applying these for transdermal or subcutaneous low-dose heparin delivery for long term use in hospital settings. 10 Heparin has also been included in gels with potential applications in tissue engineering, to control growth factor release and/or encourage tissue growth. 11 However, supramolecular gels which incorporate heparin remain very rare, and are restricted to gels based on relatively complex self-assembling peptides.…”

Development and preclinical pharmacokinetics of a novel subcutaneous thermoresponsive system for prolonged delivery of heparin

“…As demonstrated in our previous papers (Radivojša et al, 2013;Radivojsa Matanovic et al, 2015), the combination of temperature-responsive poloxamerbased hydrogels and pH-responsive nanocomplexes of heparin and chitosan seems to be an excellent platform for prolonged subcutaneous delivery of heparin. Researches in the field of thermally induced gelling systems have been of continuous interest, probably due to their wide spectra of applications, easy preparation, good acceptability and biocompatibilty (Bajpai et al, 2008;Liu et al, 2007;Matanovi c et al, 2014).…”