Prolonged renal failure in the course of atypical ethylene glycol intoxication.

Liberek, Tomasz; Śliwarska, Julita; Czurak, Krzysztof; Perkowska‐Ptasińska, Agnieszka; Weber, Ewa; Rutkowski, Bolesław

doi:10.18388/abp.2013_2037

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…Patients present with acute kidney injury and a mildly elevated anion gap that resolve with minimal intervention [ 2 , 3 ]. They describe abdominal discomfort that ranges from nausea, vomiting, and diarrhea to abdominal cramping [ 1 , 3 – 5 ]. Cases are also notable for a prior history of substance abuse or a history of depression [ 1 – 3 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

A Case of Chronic Ethylene Glycol Intoxication Presenting without Classic Metabolic Derangements

Toth‐Manikowski

Menn-Josephy

Bhatia

2014

Case Reports in Nephrology

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Acute ethylene glycol ingestion classically presents with high anion gap acidosis, elevated osmolar gap, altered mental status, and acute renal failure. However, chronic ingestion of ethylene glycol is a challenging diagnosis that can present as acute kidney injury with subtle physical findings and without the classic metabolic derangements. We present a case of chronic ethylene glycol ingestion in a patient who presented with acute kidney injury and repeated denials of an exposure history. Kidney biopsy was critical to the elucidation of the cause of his worsening renal function.

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Section: Introductionmentioning

confidence: 99%

A Case of Chronic Ethylene Glycol Intoxication Presenting without Classic Metabolic Derangements

Toth‐Manikowski

Menn-Josephy

Bhatia

2014

Case Reports in Nephrology

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Miscellaneous Drugs, Materials, Medical Devices and Techniques

Nan

2015

Side Effects of Drugs Annual

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Novel Technique for Simultaneous Ethylene Glycol and Its Metabolites Determination in Human Whole Blood and Urine Samples Using GC–QqQ–MS/MS

Tusiewicz,

Wachełko,

Zawadzki

et al. 2024

JoX

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Toxicological analyses often necessitate the identification of compounds belonging to diverse functional groups. For GC–MS analyses, derivatization of compounds belonging to different functional groups can pose a challenge and requires the development of comprehensive methods of analysis. One example could be ethylene glycol, whose widespread use is related to possible unintentional or suicidal intoxications. This fact clearly indicates the need to develop sensitive methods for the determination of ethylene glycol and its metabolites in biological material, as only such complex analysis allows for proper toxicological expertise. A simultaneous GC–QqQ–MS/MS method for the determination of ethylene glycol together with its metabolites, glyoxal and glycolic acid, as well as the detection of glyoxylic acid and oxalic acid, was developed and fully validated. A novel approach for simultaneous derivatization of substances from different groups (alcohols, aldehydes, and carboxylic acids) was established. Sample preparation included the addition of three internal standards (BHB-d4, ethylene glycol-d4 and methylglyoxal), precipitation with acetonitrile and subsequent derivatization with N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide (MTBSTFA), as well as pentafluorophenylhydrazine (PFPH). Detection was carried out with the use of triple quadrupole mass spectrometer. The ionization method was electron impact, and quantitative analysis was carried out in multiple reaction monitoring mode. The lower limit of quantification was 1 μg/mL, 0.1 μg/mL, and 500 μg/mL for ethylene glycol, glyoxal, and glycolic acid, respectively. The presented method was applied in three authentic postmortem cases of ethylene glycol intoxication.

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Prolonged renal failure in the course of atypical ethylene glycol intoxication.

Cited by 3 publications

References 7 publications

A Case of Chronic Ethylene Glycol Intoxication Presenting without Classic Metabolic Derangements

A Case of Chronic Ethylene Glycol Intoxication Presenting without Classic Metabolic Derangements

Miscellaneous Drugs, Materials, Medical Devices and Techniques

Novel Technique for Simultaneous Ethylene Glycol and Its Metabolites Determination in Human Whole Blood and Urine Samples Using GC–QqQ–MS/MS

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