Miscellaneous Drugs, Materials, Medical Devices and Techniques

Nan, Anjan

doi:10.1016/bs.seda.2015.06.007

Cited by 11 publications

(6 citation statements)

References 72 publications

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“…In addition to the antibiotic, the paste components are glycerol solvent, glycerol monostearate having emulsifying properties, and paste consistency and parabens, e.g., propyl para-hydroxybenzoate and methyl parahydroxybenzoate having preservative properties. These are substances that can cause severe allergies [67,68].…”

Section: Discussionmentioning

confidence: 99%

Drug Carriers Based on Graphene Oxide and Hydrogel: Opportunities and Challenges in Infection Control Tested by Amoxicillin Release

Trusek-Hołownia

Kijak

2021

Materials

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Graphene oxide (GO) was proposed as an efficient carrier of antibiotics. The model drug, amoxicillin (AMOX), was attached to GO using a peptide linker (Leu-Leu-Gly). GO-AMOX was dispersed in a hydrogel to which the enzyme responsible for releasing AMOX from GO was also added. The drug molecules were released by enzymatic hydrolysis of the peptide bond in the linker. As the selected enzyme, bromelain, a plant enzyme, was used. The antibacterial nature of the carrier was determined by its ability to inhibit the growth of the Enterococcus faecalis strain, which is one of the bacterial species responsible for periodontal and root canal diseases. The prepared carrier contained only biocompatible substances, and the confirmation of its lack of cytotoxicity was verified based on the mouse fibrosarcoma cell line WEHI 164. The proposed type of preparation, as a universal carrier of many different antibiotic molecules, can be considered as a suitable solution in the treatment of inflammation in dentistry.

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Section: Discussionmentioning

confidence: 99%

Drug Carriers Based on Graphene Oxide and Hydrogel: Opportunities and Challenges in Infection Control Tested by Amoxicillin Release

Trusek-Hołownia

Kijak

2021

Materials

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“…Choline is a water-soluble quaternary amine of the vitamin B group considered as an essential nutrient by the Food and Nutrition Board of the Institute of Medicine [1]. Choline endogenous synthesis from amino acid methionine is insufficient to support human choline requirements, so it is essential to maintain an appropriate dietary intake of choline, consuming fish, eggs, and meats [2]. Adequate choline daily intakes ranged from 330 to 468 mg for men, 269 to 444 mg for women, and 356 mg/day as mean estimate intake in pregnant women [3].…”

Section: Introductionmentioning

confidence: 99%

Choline: An Essential Nutrient for Skeletal Muscle

et al. 2020

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Background: Choline is an essential micronutrient with a pivotal role in several metabolic pathways contributing to liver, neurological, and hematological homeostasis. Although choline is commonly administered to improve physical performance, its effects on muscle are still unclear. The aim of this scoping review is to analyze the role of choline on skeletal muscle in terms of biological effects and clinical implications. Methods: A technical expert panel (TEP) of 6 medical specialists with expertise in muscle physiology and skeletal muscle disorders performed the review following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) model. The TEP planned a research on PubMed selecting “choline” as MeSH (Medical Subject Headings) term adding to PubMed Search Builder the terms ”skeletal muscle” and “muscle striated”. TEP considered for eligibility articles published in the last 30 years, including original researches, particularly in vitro studies, and animal and clinical studies in the English language. Results: From the 1239 studies identified, TEP included 14 studies, 3 in vitro, 9 animal, and 2 clinical studies. Conclusions: Our scoping review elucidates and summarizes the crucial role of choline in modulating muscle fat metabolism, muscle proteins homeostasis, and the modulation of inflammation and autophagy.

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“…Although CrEL (Polyethoxylated castor oil) is a choice solubilizer for TAC [43,44], with a reported solubility of 25.02 ± 1.16 mg/mL [44], it is not a physiologically inert vehicle. Dose-dependent anaphylactoid hypertensive reactions in response to CrEL are documented when used as a solubilizing vehicle in the paclitaxel formulation (Taxol) [45]. However, the paclitaxel formulation consisted of 50% CrEL as a solubilizer, resulting in an administration of 527 mg of CrEL per mL of the formulation.…”

Section: Preparation and Characterization Of Tac-nementioning

confidence: 99%

A Reversibly Thermoresponsive, Theranostic Nanoemulgel for Tacrolimus Delivery to Activated Macrophages: Formulation and In Vitro Validation

Vichare,

Crelli,

Liu

et al. 2023

Pharmaceutics

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Despite long-term immunosuppression, organ transplant recipients face the risk of immune rejection and graft loss. Tacrolimus (TAC, FK506, Prograf®) is an FDA-approved keystone immunosuppressant for preventing transplant rejection. However, it undergoes extensive first-pass metabolism and has a narrow therapeutic window, which leads to erratic bioavailability and toxicity. Local delivery of TAC directly into the graft, instead of systemic delivery, can improve safety, efficacy, and tolerability. Macrophages have emerged as promising therapeutic targets as their increased levels correlate with an increased risk of organ rejection and a poor prognosis post-transplantation. Here, we present a locally injectable drug delivery platform for macrophages, where TAC is incorporated into a colloidally stable nanoemulsion and then formulated as a reversibly thermoresponsive, pluronic-based nanoemulgel (NEG). This novel formulation is designed to undergo a sol-to-gel transition at physiological temperature to sustain TAC release in situ at the site of local application. We also show that TAC-NEG mitigates the release of proinflammatory cytokines and nitric oxide from lipopolysaccharide (LPS)-activated macrophages. To the best of our knowledge, this is the first TAC-loaded nanoemulgel with demonstrated anti-inflammatory effects on macrophages in vitro.

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Miscellaneous Drugs, Materials, Medical Devices and Techniques

Cited by 11 publications

References 72 publications

Drug Carriers Based on Graphene Oxide and Hydrogel: Opportunities and Challenges in Infection Control Tested by Amoxicillin Release

Drug Carriers Based on Graphene Oxide and Hydrogel: Opportunities and Challenges in Infection Control Tested by Amoxicillin Release

Choline: An Essential Nutrient for Skeletal Muscle

A Reversibly Thermoresponsive, Theranostic Nanoemulgel for Tacrolimus Delivery to Activated Macrophages: Formulation and In Vitro Validation

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