Prolonged release from orodispersible films by incorporation of diclofenac-loaded micropellets

Speer, Isabell; Lenhart, Vincent; Preis, Maren; Breitkreutz, Jörg

doi:10.1016/j.ijpharm.2018.11.013

Cited by 37 publications

(18 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is suggested that upon contact with water, compared to DCF (solubility in water: 0.005 mg/mL), the hydrochloride form of LID (used in this study, solubility in water: 0.6 mg/mL) incorporated within the hydrophilic ALG-CMC 3 matrix dissolves and diffuses quicker through the film, and thus a larger amount of drug is released over time. Overall, the data show that it is possible to carefully tune the release rate of drug using one particular system, as it is demonstrated by several others (Vasilev et al, 2011; Wang et al, 2016; Maver et al, 2018a; Speer et al, 2019). Using thinner and thicker multi-layer coatings, the release rate can be extended even further (desired in treatment of chronic wounds is for multiple days).…”

Section: Resultssupporting

confidence: 62%

Polysaccharide Thin Solid Films for Analgesic Drug Delivery and Growth of Human Skin Cells

et al. 2019

View full text Add to dashboard Cite

Chronic wounds not only lower the quality of patient's life significantly, but also present a huge financial burden for the healthcare systems around the world. Treatment of larger wounds often requires the use of more complex materials, which can ensure a successful renewal or replacement of damaged or destroyed tissues. Despite a range of advanced wound dressings that can facilitate wound healing, there are still no clinically used dressings for effective local pain management. Herein, alginate (ALG) and carboxymethyl cellulose (CMC), two of the most commonly used materials in the field of chronic wound care, and combination of ALG-CMC were used to create a model wound dressing system in the form of multi-layered thin solid films using the spin-assisted layer-by-layer (LBL) coating technique. The latter multi-layer system was used to incorporate and study the release kinetics of analgesic drugs such as diclofenac and lidocaine at physiological conditions. The wettability, morphology, physicochemical and surface properties of the coated films were evaluated using different surface sensitive analytical tools. The influence of in situ incorporated drug molecules on the surface properties (e.g., roughness) and on the proliferation of human skin cells (keratinocytes and skin fibroblasts) was further evaluated. The results obtained from this preliminary study should be considered as the basis for the development “real” wound dressing materials and for 3D bio-printing applications.

show abstract

Section: Resultssupporting

confidence: 62%

Polysaccharide Thin Solid Films for Analgesic Drug Delivery and Growth of Human Skin Cells

et al. 2019

View full text Add to dashboard Cite

show abstract

“…To overcome this problem, micropellets with microcrystalline cellulose and sodium carboxymethylcellulose were prepared. The researchers investigated the incorporation of prolonged release small-size micropellets into ODFs with diclofenac as a model drug [93]. After disintegration of ODFs in the oral cavity, the incorporated matrix particles or micropellets can be swallowed together with the saliva after which the drug is slowly released in the gastrointestinal tract.…”

Section: Prolonged Drug Releasementioning

confidence: 99%

Oromucosal films: from patient centricity to production by printing techniques

Tian

Orlu

Woerdenbag

et al. 2019

Expert Opinion on Drug Delivery

Self Cite

View full text Add to dashboard Cite

Introduction: Oromucosal films, comprising mucoadhesive buccal films (MBFs) and orodispersible films (ODFs), are considered patient-centric dosage forms. Target groups are patients with special needs. Various active pharmaceutical ingredients have been shown to be suitable for oromucosal film production. A shift is seen in the production techniques, from conventional solvent casting to printing techniques. Areas covered: In this review, the patient acceptability of oromucosal films is discussed. An overview is given of the small molecule drugs, biopharmaceuticals and herbal extracts that have been incorporated so far. Finally, the current state of 2D and 3D printing techniques for production purposes is discussed. Expert opinion: The patient-centric features are important for the further development and acceptance of this oral solid dosage form. Oromucosal films perfectly fit in the current attention for personalized medicine. Both MBFs and ODFs are intended for either a local or a systemic effect. For buccal absorption, sufficient mucoadhesion is one of the most important criteria an oromucosal film must comply with. For the preparation, the solvent casting technique is still predominately used. Some limitations of this production method can be tackled by printing techniques. However, these novel techniques introduce new requirements, yet to be set, for oromucosal film preparation.

show abstract

“…The other possibility is to suspend the drug in the aqueous solution of the polymer used for casting the film, which allows uncontrolled recrystallization to be avoided [8,16,17,[19][20][21][22][23][24]. However, the formulation of such biphasic films, containing suspended API, implies serious challenges regarding the uniformity of the content, texture, and appropriate mechanical properties of the films [15].…”

Section: Introductionmentioning

confidence: 99%

Technology of Orodispersible Polymer Films with Micronized Loratadine—Influence of Different Drug Loadings on Film Properties

2020

View full text Add to dashboard Cite

The production of orodispersible films (ODFs) with suspended insoluble drug substances is still a challenge, mainly due to the difficulty associated with achieving a proper homogeneity and mechanical properties of the films. Hypromellose (HPMC) and a mixture of polyvinyl alcohol (AP) and povidone (PVP) were compared in terms of their suitability for ODFs incorporating suspended micronized loratadine (LO) in a concentration range of 10%–40%. In a planetary mixer (Thinky), a uniform dispersion of LO in an aqueous viscous casting solution was obtained. The suspended LO particles caused dose-dependent changes in the viscosity of the casting mass and affected the mechanical quality of ODFs. Drug concentrations higher than 30% reduced the film flexibility and tear resistance, depending on the polymer type. LO films with a thickness of 100 µm disintegrated within 60-100 s, with no significant influence of the LO content in the range 10%–30%. HPMC films, regardless of the drug concentration, met the pharmacopoeial requirements regarding the uniformity of the drug content. AP/PVP films were too elastic, and the drug content uniformity was not achieved. The conclusion is that, using an HPMC matrix, it is possible to obtain a high load of a poorly water-soluble drug (30% of dry film mass corresponds to a dose of 5 mg per 1.5 cm2) in ODFs characterized by proper physical characteristics.

show abstract

Prolonged release from orodispersible films by incorporation of diclofenac-loaded micropellets

Cited by 37 publications

References 48 publications

Polysaccharide Thin Solid Films for Analgesic Drug Delivery and Growth of Human Skin Cells

Polysaccharide Thin Solid Films for Analgesic Drug Delivery and Growth of Human Skin Cells

Oromucosal films: from patient centricity to production by printing techniques

Technology of Orodispersible Polymer Films with Micronized Loratadine—Influence of Different Drug Loadings on Film Properties

Contact Info

Product

Resources

About