Prolonged fever as an unusual manifestation of the hyaline vascular type of Castleman’s disease in the chest: report and review of the literature

Emad, Ali

doi:10.1007/s002770050335

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…16 The plasma cell variant tends to be a local form, which occurs more commonly in young adults and is amenable to local therapy. 17,18 The multicentric form occurs in older adults or in HIV infected patients with diffuse adenopathy and a variable, but often fatal clinical course in which 20 to 30% of patients develop Kaposi sarcoma or B-cell lymphoma. 19,20 Immunophenotyping and IgG gene rearrangements of the plasma cell variant in CT indicate that patients usually have polyclonal lesions.…”

Section: Discussionmentioning

confidence: 99%

Castleman's Disease: A Study of a Rare Lymphoproliferative Disorder in a University Hospital

Abdul-Rahman¹,

Alamri²,

Ghallab

2009

Clinical medicine. Blood disorders

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Castleman's disease (CD) is a group of rare lymphoproliferative disorders sharing characteristic clinical and histological features, and usually accompanied by a marked systemic inflammatory response. Three histological patterns of lymph nodes were described: the hyaline-vascular, the plasma-cell and the mixed types. The former is more common (80%-90%) and tends to be localized. The plasma cell type is more aggressive and usually multicentric. It is interesting that the inflammatory manifestations seem to be related to a lymph node lesion, because the systemic symptoms and inflammatory activity can return to normal after surgical excision or successful medical treatment of the disease. We report here our 15-year experience with this rare disease in King Fahd Hospital of the University, Al-Khobar, Saudi Arabia, focusing on the clinical features, therapy, and patients'outcome.

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Section: Discussionmentioning

confidence: 99%

Castleman's Disease: A Study of a Rare Lymphoproliferative Disorder in a University Hospital

Abdul-Rahman¹,

Alamri²,

Ghallab

2009

Clinical medicine. Blood disorders

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Localised Hyaline Vascular Type of Castleman's Disease Mimicking Adult-Onset Still's Disease

Lin

Chao

1999

Clinical Rheumatology

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A previously healthy 18-year-old boy presented with daily spiking fever, polyarthritis, and evanescent skin rashes, as well as hepatomegaly and Raynaud's phenomena for 2 months. He was initially diagnosed with adult-onset Still's disease (AOSD). During the period of follow-up, intermittent fever and migratory polyarthritis persisted and an insidiously growing mass over the right axillary region was noted 1 year after the diagnosis of AOSD. Excisional biopsy of the mass revealed a group of lymph nodes with histological features of the hyaline vascular type of Castleman's disease. The patient's symptoms disappeared soon after excision of the lymph nodes. evanescent rash, lymphadenopathy, hepatosplenomegaly and serositis [5]. A clinical picture compatible with the diagnosis of AOSD has not been described in the localised hyaline vascular type of Castleman's disease. We report such a case in an 18-year-old male patient who presented prolonged fever and polyarthritis with an initial diagnosis of AOSD. The diagnosis of hyaline vascular type of Castleman's disease was made 1 year later, when the patient developed an insidiously growing mass over the right axilla.

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Prolonged fever as an unusual manifestation of the hyaline vascular type of Castleman’s disease in the chest: report and review of the literature

Cited by 2 publications

References 35 publications

Castleman's Disease: A Study of a Rare Lymphoproliferative Disorder in a University Hospital

Castleman's Disease: A Study of a Rare Lymphoproliferative Disorder in a University Hospital

Localised Hyaline Vascular Type of Castleman's Disease Mimicking Adult-Onset Still's Disease

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