Castleman's Disease: A Study of a Rare Lymphoproliferative Disorder in a University Hospital

Abdul-Rahman, Ibrahiem Saeed; Alamri, Ali; Ghallab, Khalid Qassim

doi:10.4137/cmbd.s2161

Cited by 5 publications

(2 citation statements)

References 69 publications

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“…On the other hand, hyaline vascular variant is characterized by large follicles, showing marked capillary proliferation and hyalinization in a mass of lymphoid tissue. The lymphocytes form a concentric layer at the periphery of these follicles that comprise the mantle zone [ 1 , 3 , 4 ].…”

Section: Discussionmentioning

confidence: 99%

IL-5 in the plasma-cell-dominant Castleman disease: a nosological entity

et al. 2016

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A 40-year-old male presented with a history of low-grade fever, weight loss, night sweats and breathlessness of 3 months duration. On examination, the patient had freely mobile lump in left lumbar region. The lump was surgically excised. Histological examination and immunohistochemistry of the specimen were consistent with the diagnosis of plasma cell variant of the Castleman disease. The patient had polyclonal hypergammaglobulinemia, anemia, eosinophilia and elevated interleukin (IL)-6 level. The level of IL-5 was not measured; however, the presence of eosinophilia indirectly suggests an increased IL-5 level. He obtained complete remission after resection of lump and 20 months of surgery had no signs and symptoms of diseases recurrence with normal hematological parameters. We discuss the role of IL-5 in the pathophysiology of the Castleman disease along with dysregulated overproduction of IL-6.

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Section: Discussionmentioning

confidence: 99%

IL-5 in the plasma-cell-dominant Castleman disease: a nosological entity

et al. 2016

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“…The vascular endothelial growth factor (VEGF) has been found to be elevated in lymph nodes of patients with Castleman; this can induce blood vessel proliferation [5,8].…”

Section: Etiologymentioning

confidence: 99%

Castleman’s Disease of the Pleura: Case Presentation and Review of Literature

Loarte¹,

Araguez²,

Flores³

et al. 2012

IJCM

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Purpose: Castleman's Disease is a very rare medical disease and the presence of this condition in the pleura is even rarer and there are only few reported cases. The presence of symptoms is also unusual and has been mostly described in multicentric cases of castleman's disease instead of solitary lesions (unicentric castleman). We report a case of unicentric pleural castlema's disease with presence of constitutional symptoms. Methods: A 36-year-old male without any significant past medical history who presented to the emergency due to an incidental large pleural effusion seen in chest radiograph, but referring chronic constitutional symptoms consistent of significant weight loss and chronic cough. Results: Chest computed tomography revealed a mass and several attemps with minimally invase approach failed to identify the lesion. The mass was excised through VATS but due to its significant vascularity, it had to be converted to open thoracotomy. Conclusion: The treatment of unicentric lesions is mainly complete surgical excision and the prognosis is excellent with some chances of recurrence. There are less than one dozen of reported pleural castleman reported in the literature. This case evidence than unicentric lesion may exhibit constitutional symptoms and confirmed than lesions above 5 cm can be removed by VATS but the chances for conversion to an open thoracotomy are high.

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