Prolonged eradication of urogenital mycoplasmas after administration of tetracycline to men in the Antarctic.

Macleod, Angus; Furr, P. M.; Taylor‐Robinson, David

doi:10.1136/sti.52.5.337

Cited by 6 publications

(5 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In some cases, however, the organisms could not be reisolated and their disappearance was not due to their sensitivity to the antibiotic. This is the first evidence of spontaneous clearance of ureaplasmas from adult male patients and contrasts with the results of previous studies where persistence for at least a year was noted in the absence of antibiotic therapy (Holmes et al, 1974;MacLeod et al, 1976).…”

Section: Discussioncontrasting

confidence: 98%

Treatment of nongonococcal urethritis with rifampicin as a means of defining the role of Ureaplasma urealyticum

Coufalik

Taylor‐Robinson

Csonka

1979

Sexually Transmitted Infections

View full text Add to dashboard Cite

SUMMARY The results of a double-blind therapeutic trial on 217 men with nongonococcal urethritis (NGU) show that minocycline was more effective than rifampicin. Before treatment Chlamydia trachomatis was isolated from 43 % of men, Ureaplasma urealyticum from 59 %, and Mycoplasma hominis from 22%. Chlamydiae and ureaplasmas were isolated less frequently from men with a recent history of NGU. Minocycline was given to 94 patients, and after treatment chlamydiae were isolated from only one of 40 initially chlamydia-positive patients and ureaplasmas from only five of 57 initially ureaplasma-positive patients. Although most patients responded clinically, failure and partial recovery rather than complete recovery were observed more often among those who were infected with ureaplasmas. Rifampicin was given to 123 patients, after which chlamydiae were isolated from only one of 53 initially chlamydia-positive men whereas ureaplasmas, insensitive to the antibiotic in vitro, were isolated from 55 of 68 men who had initially positive results. Patients infected with ureaplasmas failed to respond to rifampicin treatment significantly more often than those who were not infected. This was also observed when only patients who had never had NGU or who had not had a recent episode were considered. Furthermore, 24 (44 %) of the 55 men whose ureaplasmas persisted failed to recover whereas only one (7-7 %) of 13 men whose ureaplasmas disappeared did not respond to treatment. These results suggested that ureaplasmas were a cause of urethritis in some of the men (an estimated 10 % at least). In addition, Reiter's disease developed in two men treated with rifampicin from whom only ureaplasmas had beenisolatedinitially. M. hominis did not seem to have an important pathogenic role in NGU and there was evidence that ureaplasmas were an unlikely cause of urethritis in some men since the organisms persisted despite complete clinical recovery.

show abstract

Section: Discussioncontrasting

confidence: 98%

Treatment of nongonococcal urethritis with rifampicin as a means of defining the role of Ureaplasma urealyticum

Coufalik

Taylor‐Robinson

Csonka

1979

Sexually Transmitted Infections

View full text Add to dashboard Cite

show abstract

“…Large numbers ( 3 105 c.c.u./ml) were found rarely in the urines of either men or women. Although previous observations (Holmes, Furr & Taylor-Robinson, 1974;MacLeod, Furr & Taylor-Robinson, 1976) showed that, without sexual contact, ureaplasmas and mycoplasmas could persist in the male urethra for a year or more, it is clear that they tend to disappear, being found least frequently in both men and women in the older age group.…”

Section: Resultsmentioning

confidence: 89%

Prevalence and significance ofMycoplasma hominisandUreaplasma urealyticumin the urines of a non-venereal disease population

Furr

Taylor‐Robinson

1987

Epidemiol. Infect.

View full text Add to dashboard Cite

SUMMARYUreaplasma urealyticum organisms (ureaplasmas) and Mycoplasma hominis organisms (mycoplasmas) were sought in mid-stream urines collected from 200 men and 200 women attending hospital with conditions of a non-venereal nature. In addition, the urines from 100 male and 100 female healthy volunteers were examined. Overall, ureaplasmas were isolated four times more often than mycoplasmas. In individuals less than 50 years ofage, the organisms were found in about 20 % of men and about 40 % of women. In individuals 50 years or older, they were found about one-third to one-half as frequently. Centrifugation of urine and examination of the resuspended deposit did not increase the isolation rates. In men, the numbers of organisms in the urine were usually small ( < 103 c.c.u./ml) with less than tenfold more in the urine of women. The occurrence of 51-> 1000 leucocytes per mm3 in some of the urines was not associated with either the presence or an increased number of ureaplasmas/mycoplasmas, whereas they were associated with the presence of 105 or more bacteria/ml. The significance of these findings in the context of defining the role of ureaplasmas/mycoplasmas in genital-tract disease is discussed.

show abstract

“…However, isolates were not serotyped, and it was not possible to determine whether long-term carriage was due to persistence of a particular strain. Ureaplasmas have been recovered from meatal swabs collected over 13 months (12) and 2.5 years (10) from Antarctic base personnel, indicating that chronic urethral infection may occur without the need for reinfection by sexual contact.…”

Section: Discussionmentioning

confidence: 99%

“…In all such patients, ureaplasmas were reisolated, and this may have been due to inadequate clearance or to reinfection. MacLeod et al (12) demonstrated that, after adequate antibiotic treatment of Antarctic base personnel, urethral infection recurred only after further sexual contact. This suggests that any serotype recovered after treatment should be that carried by the sexual partner, and this was confirmed with our patient B.…”

Section: Discussionmentioning

confidence: 99%

Ureaplasma urealyticum serotypes in urinary tract disease

Hewish¹,

Birch²,

Fairley³

1986

J Clin Microbiol

View full text Add to dashboard Cite

Ureaplasma urealyticum cultures from 124 patients with urinary tract disease were serotyped by indirect immunofluorescence, using antisera to serotypes I to VIII. A similar range of serotypes was recovered from first-voided, midstream, and bladder-aspiration (SPA) urine, upper urinary tract samples, and vaginal swabs. Serotype VI was predominant (44/124) among the samples, whereas serotypes V (1/124 samples) and VII (0/124 samples) were uncommon. Twenty of 124 cultures contained more than one serotype, and three cultures were untypeable. Serotypes cultured from bladder urine were also present in vaginal and urethral samples, although these samples often carried additional serotypes. Consecutive SPA samples from the same patient invariably contained the same serotype, whereas some consecutive midstream urine samples showed a loss or gain of serotypes with time. One patient carried the same serotype in SPA urine over a period of 13 months. The pattern of serotypes recovered from the urinary tract was similar irrespective of the sampling site, the site of infection, the clinical diagnosis and renal function of the patient, and the presence or absence of other microorganisms. Colonization above the urethra and association with urinary tract disease appeared to be serotype independent.

show abstract

Prolonged eradication of urogenital mycoplasmas after administration of tetracycline to men in the Antarctic.

Cited by 6 publications

References 11 publications

Treatment of nongonococcal urethritis with rifampicin as a means of defining the role of Ureaplasma urealyticum

Treatment of nongonococcal urethritis with rifampicin as a means of defining the role of Ureaplasma urealyticum

Prevalence and significance ofMycoplasma hominisandUreaplasma urealyticumin the urines of a non-venereal disease population

Ureaplasma urealyticum serotypes in urinary tract disease

Contact Info

Product

Resources

About