Prolonged dysbiosis and altered immunity under nutritional intervention in a physiological mouse model of severe acute malnutrition

A Murine Model of Maternal Micronutrient Deficiencies and Gut Inflammatory Host-microbe Interactions in the Offspring

“…Furthermore, the LM pups did not exhibit any overt signs of stunting, such as reduced tail length and body weight, perhaps due to the specific time frame of the model and the absence of more severe forms of malnutrition. 39 , 46 …”

Lab-on-chip technologies for exploring the gut–immune axis in metabolic disease

“…Parabacteroides/Bifidobacterium ↑ Alanine aminotransferase in women ↓ Visceral adipose tissue in men ↓ Bilophila ↓ Malnutrition 100 Male mice (n = 3-40) 102 Male mice (n = 5-7) 103 Obese male mice (n = 6)…”

Gut microbiota and childhood malnutrition: Understanding the link and exploring therapeutic interventions

“…Inadequate intake of protein energy or micronutrients like iron, vitamin A, and iodine, which are the most prevalent types of deficits in undernutrition, can lead to clinical signs of undernutrition [ 27 ]. Due to insecure nutritional conditions in developing countries, weaning and introducing solid foods in turn can be a risk indicator for gut microbial balance of undernourished children [ 67 ]. Recent findings have shown that the gut microbiota of malnourished children is less diverse and mature than that of their healthy peers [ 68 ].…”

“…Conversely, the study conducted by Hidalgo‐Villeda et al on SAM mice, indicated a lower concentration of mucin degrader Akkermansia , an increase in bacteria attached to the terminal ileum, and altered mucosal layer morphology. Also, in the previous study, the reduction of T helper 17 (Th17)‐inducing bacteria, Candidatus arthromitus , and as a result the imbalance of Th17 to regulatory T cells ratio was related to the physiology of SAM mice [ 67 ]. Another diligent study reported that Ruminococcus gnavus and Clostridium symbiosum can be able to prevent the growth‐restraining effects of immature gut microbiota of undernourished children in germ‐free mice [ 69 ].…”