Prolonged Cough Suppression

Townsend, Edward H.

doi:10.1056/nejm195801092580202

Cited by 13 publications

(3 citation statements)

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“…Becker and Szvift (2) showed that such resin complexes have a substantially lower toxicity than correspontl-ing soluble salts of the same drugs. Their data were confirmed by Townsend (5) and by Cass and Frederik (6,7). Chan and Hays (4) applied these principles to the antitussive field and, in addition, showed in human subjects that the antitussive potency of dihydrocodeinone resin complex couUl be synergi/.ed by the addition of phenyltoloxamine resin complex.…”

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confidence: 56%

“…Chan and Hays (4) applied these principles to the antitussive field and, in addition, showed in human subjects that the antitussive potency of dihydrocodeinone resin complex couUl be synergi/.ed by the addition of phenyltoloxamine resin complex. Their data were confirmed by Townsend (5) and by Cass and Frederik (6,7). In previous studies (8,9) this author delineated the clinical value of chlorpheniramine alone and witb antitussive medications.…”

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Antitussive Medication in Asthma, Emphysema and Chronic Bronchitis

Silbert¹

1961

Allergy

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Cough, failure to raise inspissated mucus, wheezing and the general symptom syndrome associated with chronic bronchitis, pollen bronchitis, pollen asthma, chronic bronchial asthma, emphysema, antl broncbiectasis have long been a vexing problem to the practitioner in all fields of medicine. The search for an effective antitussive medication which would not abolish the normal activity of the cilial lining of the bronchial tree and yet afford the necessary free flow of secretion and the release of the heavier inspissated mucus has been the subject of cooperative study. Therapeutic agents which will minimize, if not completely relieve, the aggravating chronicity of coughs in the above-mentioned bronchial conditions has been under study for the past fifteen months.The unique advantage of ion exchange resin complexes for prolonging the activity of various medications and for reducing their toxicity has heen adequately demonstratetl in previously published data. Sensenbach and Hays (i) have shown that the combination of a variety of therapeutically useful drugs with certain ion exchange resins to form resin complexes is capable of producing a drug having a predictable rate of release in the gastro-intestinal tract through the mechanism of ion exchange. Becker and Szvift (2) showed that such resin complexes have a substantially lower toxicity than correspontl-

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Antitussive Medication in Asthma, Emphysema and Chronic Bronchitis

Silbert¹

1961

Allergy

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“…Sideeffects are not frequently mentioned, one study noting constipation and facial pruritis. 6 No instances of severe reactions or idiosyncrasy relating to this drug were found in the literature. Each teaspoon of the suspension contains 5 mg. of dihydrocodeinone and 10 mg. of phenyltoloxamine, both as exchange resin complexes.…”

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confidence: 99%