Sedation and Tranquilization

Klerman, Gerald L.; Dimascio, Alberto; Havens, Leston L.; Snell, John E.

doi:10.1001/archpsyc.1960.01710010016002

Cited by 17 publications

(2 citation statements)

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“…According to the CS results, gabapentin was the only substance that managed to drop the score from 2 to 0, in 4/25 cats (16%), bypassing the intermediate score between them. Only eight cats were considered sedated (ie, they produced sufficient CNS depression to cause muscle relaxation and an apparent unawareness of the environment) 30 – seven were in the gabapentin group (28%), including the Bengal and the outlier cat weighing 11 kg, and one was from the melatonin group (4%). Therefore, gabapentin statistically significantly provoked more sedation than the other treatments ( P = 0.004).…”

Section: Resultsmentioning

confidence: 99%

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Behavioral and cardiovascular effects of a single dose of gabapentin or melatonin in cats: a randomized, double-blind, placebo-controlled trial

Tuleski

Silveira

Bastos

et al. 2022

Journal of Feline Medicine and Surgery

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Objectives The aim of this study was to verify whether a single oral dose of gabapentin (100 mg) or melatonin (3 mg) given 60 mins before a cardiac evaluation would reduce anxiety without interfering with heart rate (HR), systemic blood pressure (SBP), electrocardiogram (ECG) and echocardiographic indexes. Methods Seventy-five client-owned healthy cats underwent two sets of cardiac assessments 60 mins apart, randomly divided into gabapentin, melatonin and placebo groups. The interval between treatment and the second ECG and SBP measurement was 60 mins, and 70 mins for echocardiography. A compliance score (CS) classified the behavior, focusing on the ease of handling. Results Most variables did not change between the examinations. The placebo group showed more significant changes (SBP, tricuspid annular plane systolic excursion, HR during echocardiography, aortic flow velocity, S′ wave from lateral mitral annulus), but they were not considered to be hemodynamically relevant. Gabapentin and melatonin significantly increased the cats’ compliance without interfering with cardiac assessment. Eight cats presented with mild sedation, seven after gabapentin and one after melatonin. No major side effects were observed. Conclusions and relevance Gabapentin tranquilized the cats when it was given 60 mins prior to ECG and SBP measurement, and 70 mins prior to echocardiography, without interfering with systolic echocardiographic indexes. Melatonin also decreased the CS, but without sedation in most cases. The waiting period may have relaxed the cats in the placebo group, resulting in lower SBP measurements. However, this tranquility did not last as some echocardiographic changes signaled a sympathetic predominance.

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Section: Resultsmentioning

confidence: 99%

“…Tranquilization was defined as a reduction in anxiety, while sedation had more potent central nervous system (CNS) depression, compromising performance and environment perception. 30 When observed, sedation was classified according to a score developed for cats, 29 described as sedation score (SS) (Table 1).…”

Section: Methodsmentioning

confidence: 99%