Proliferative verrucous leukoplakia: high incidence of gingival squamous cell carcinoma

Bagán, José; Jiménez, Yolanda; Sanchis, José M.; Poveda, Rafael; Milian, Mari A.; Murillo, Judith; Scully, Crispian

doi:10.1034/j.1600-0714.2003.00167.x

Cited by 133 publications

(196 citation statements)

References 20 publications

Supporting

Mentioning

150

Contrasting

Unclassified

Order By: Relevance

“…PVL is known for its aggressive pathology, given its multifocal involvement, tendency to recur after removal, and high rate of malignant transformation, which can be higher than 70%, reaching 100% in some cases (14)(15)(16). 74.62% of the published cases report a mean malignant transformation rate of 6.08 years (14)(15)(16)(17)(18)(19)(20). Therefore, the early diagnosis of PVL can be beneficial in the prognosis of these patients.…”

Section: Discussionmentioning

confidence: 99%

“…1). Nevertheless, the latest published case series have reported an increased tendency towards PVL lesions settling in keratinized mucosa: gingiva, alveolar ridge and hard palate (18)(19)(20) (Fig. 2, 3 and 4).…”

Section: Discussionmentioning

confidence: 99%

“…Barely a few decades ago, a rare form of oral leukoplakia known as proliferative verrucous leukoplakia (PVL) was first reported. It presents specific characteristics, mainly a more aggressive biological behaviour than other forms of leukoplakia expressed by: a tendency towards multifocality; a high probability of recurrence; and a high rate of malignant transformation, which can range between 40 and 100% in a follow-up period of 4.4 to 11.6 years (14)(15)(16)(17)(18)(19)(20). PVL was first described in 1985 by Hansen et al as a long-term progressive condition (sometimes more than 20 years) which develops initially as a white plaque of hyperkeratosis that eventually becomes a multifocal disease with confluent, exophytic and proliferative features.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Proliferative verrucous leukoplakia: A proposal for diagnostic criteria

Cerero-Lapiedra¹,

et al. 2010

View full text Add to dashboard Cite

Proliferative verrucous leukoplakia (PVL) is a rare form of oral leukoplakia, which was first described in 1985 by Hansen et al. Since then, various published case series have presented PVL as a disease with aggressive biological behaviour due to its high probability of recurrence and a high rate of malignant transformation, usually higher than 70%. PVL is a long-term progressive condition, which is observed more frequently in women and elderly patients over 60 years at the time of diagnosis. Eventually, PVL tends to become multifocal with a progressive deterioration of the lesions, making it more and more difficult to control. Tobacco use does not seem to have a significant influence on the appearance or progression of PVL. These lesions may occur both in smokers and nonsmokers. Nevertheless, at present, the aetiology of PVL remains unclear as well as its management and diagnosis, which is still retrospective, late and poorly defined, lacking consensus criteria. Therefore, the aim of this study is to propose a set of diagnostic criteria to allow for the early and objective identification of PVL cases, and thereby conduct an adequate management. The proposal includes five major criteria and four minor criteria, as well as specific combinations among them in order to establish a correct and objective diagnosis of proliferative verrucous leukoplakia.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Proliferative verrucous leukoplakia: A proposal for diagnostic criteria

Cerero-Lapiedra¹,

et al. 2010

View full text Add to dashboard Cite

show abstract

“…associated with this lesion. Four stages have been described in its development, initially as a simple hyperkeratosis without epithelial dysplasia, followed by verrucous hyperplasia, verrucous carcinoma, and finally conventional carcinoma [20][21][22].…”

Section: Leukoplakia and Epstein Barr Virus (Ebv)mentioning

confidence: 99%

Leuloplakia - Review of A Potentially Malignant Disorder

Abidullah

Grover²,

Gaddikeri

et al. 2014

JCDR

View full text Add to dashboard Cite

“…[3] According to some authors, chances of PVL transforming into oral carcinoma are more than 60%. [6,7] Erythroplakia is a velvety bright red plaque that is not clinically or histologically ascribed to any other condition. [1] Clinical features involve a high prevalence in males and occur in the floor of the mouth, tongue, soft palate, and retromolar pad.…”

Section: Introductionmentioning

confidence: 99%

Role of curcumin in management of potentially malignant disorders: A review of literature

Vasudev¹,

Vakade²,

Paramesh³

et al. 2016

JCRI

View full text Add to dashboard Cite

Potentially malignant disorders (PMD) are premalignant lesions or conditions having a high rate of malignant transformation. The risk of malignancy accounts for more than 50% in the commonly occurring oral PMD. There is a need to identify oral PMD early on and prevent their transformation into malignancy. Oxidative stress plays a major role in the pathogenesis of oral PMD. Curcumin, an antioxidant has shown promising results in oral PMD by reducing oxidative stress by various mechanisms. The aim of this article is to shed light on the use of curcumin in different oral PMD, its benefits, and shortcomings based on previously published literature.

show abstract

Proliferative verrucous leukoplakia: high incidence of gingival squamous cell carcinoma

Abstract: Cancer developing in patients with PVL manifested particularly on the gingiva.

Cited by 133 publications

References 20 publications

Proliferative verrucous leukoplakia: A proposal for diagnostic criteria

Proliferative verrucous leukoplakia: A proposal for diagnostic criteria

Leuloplakia - Review of A Potentially Malignant Disorder

Role of curcumin in management of potentially malignant disorders: A review of literature

Contact Info

Product

Resources

About