Proliferative activity and diagnostic delay in oral cancer

Seoane, Juan; Pita-Fernández, Salvador; Gómez, Isabel Neira; Vázquez, Inés; López-Cedrún, José Luís; Agustín, Domingo De; Varela‐Centelles, Pablo

doi:10.1002/hed.21338

Cited by 31 publications

(33 citation statements)

References 34 publications

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“…A study of the state of Thuringia, Germany, described that almost 50% of their cases were diagnosed in stage IV (Guntinas-Lichius et al 2009). These data underlined the results of clinical studies that two-thirds of the cases are diagnosed at an advanced stage (Robert Koch Institut 2010;Sankaranarayanan et al 2005;Sargeran et al 2008;Seoane et al 2010). In addition, the data of the Cancer Registry in Schleswig-Holstein as well as in Thuringia showed no improvement with regard to stage I or II over the particular time period they observed.…”

Section: Discussionsupporting

confidence: 54%

Trends in incidence, tumour sites and tumour stages of oral and pharyngeal cancer in Northern Germany

Hertrampf

Wiltfang

Katalinic

et al. 2011

J Cancer Res Clin Oncol

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Detailed population-based results described important variations with regard to tumour sites, stages and areas. These data play a central role as they provide the epidemiological profile of a tumour. This profile, together with possible targeted knowledge evaluations of the public and the health care providers involved, can be used as a prerequisite for health care activities and for the development of preventive strategies for targeted public awareness campaigns.

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Section: Discussionsupporting

confidence: 54%

Trends in incidence, tumour sites and tumour stages of oral and pharyngeal cancer in Northern Germany

Hertrampf

Wiltfang

Katalinic

et al. 2011

J Cancer Res Clin Oncol

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“…The tumour growth rate may play the role of a confounding factor in the relationship between diagnostic delay and disease-stage or survival, as patients with aggressive tumours and bad prognosis do not usually present diagnostic delay whereas tumours with low proliferation rates elicit good prognosis despite long diagnostic delays (28). Unfortunately, the evidence on tumour proliferation activity that could corroborate this hypothesis is scarce.…”

Section: Discussionmentioning

confidence: 99%

Factors related to late stage diagnosis of oral squamous cell carcinoma

Seoane-Romero¹,

Vázquez-Mahía²,

Seoane³

et al. 2012

Med Oral

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Aims: To identify factors related to advanced-stage diagnosis of oral cancer to disclose high-risk groups and facilitate early detection strategies. Study design: An ambispective cohort study on 88 consecutive patients treated from January 1998 to December 2003. Inclusion criteria: pathological diagnosis of OSCC (primary tumour) at any oral site and suffering from a tumour at any TNM stage. Variables considered: age, gender, smoking history, alcohol usage, tumour site, macroscopic pattern of the lesion, co-existing precancerous lesion, degree of differentiation, diagnostic delay and TNM stage. Results: A total of 88 patients (mean age 60±11.3; 65.9% males) entered the study. Most patients (54.5%) suffered no delayed diagnosis and 45.5% of the carcinomas were diagnosed at early stages (I-II). The most frequent clinical lesions were ulcers (70.5%). Most cases were well- and moderately-differentiated (91%). Univariate analyses revealed strong associations between advanced stages and moderate-poor differentiation (OR=4.2; 95%CI=1.6-10.9) or tumour site (floor of the mouth (OR=3.6; 95%CI=1.2-11.1); gingivae (OR=8.8; 95%CI=2.0-38.2); and retromolar trigone (OR=8.8; 95%CI=1.5-49.1)). Regression analysis recognised the site of the tumour and the degree of differentiation as significantly associated to high risk of late-stage diagnosis. Conclusions: Screening programmes designed to detect asymptomatic oral cancers should be prioritized. Educational interventions on the population and on the professionals should include a sound knowledge of the disease presentation, specifically on sites like floor of the mouth, gingivae and retromolar trigone. More studies are needed in order to analyse the part of tumour biology on the extension of the disease at the time of diagnosis. Key words: Oral cancer, advanced-stage, diagnosis, cohort study.

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“…The Ki-67 value is a measure of cell proliferation (Seoane et al 2010). In this study, researchers wish to compare Ki-67 values in individuals diagnosed with head and neck cancer to a reference value for healthy individuals.…”

Section: Additional Resources For Glimmpsementioning

confidence: 99%

GLIMMPSE: Online Power Computation for Linear Models with and without a Baseline Covariate

Kreidler¹,

Muller²,

Grunwald³

et al. 2013

J. Stat. Soft.

288

181

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GLIMMPSE is a free, web-based software tool that calculates power and sample size for the general linear multivariate model with Gaussian errors (http://glimmpse.SampleSizeShop.org/). GLIMMPSE provides a user-friendly interface for the computation of power and sample size. We consider models with fixed predictors, and models with fixed predictors and a single Gaussian covariate. Validation experiments demonstrate that GLIMMPSE matches the accuracy of previously published results, and performs well against simulations. We provide several online tutorials based on research in head and neck cancer. The tutorials demonstrate the use of GLIMMPSE to calculate power and sample size.

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Proliferative activity and diagnostic delay in oral cancer

Abstract: These results seem to suggest that survival from oral cancer is affected more by the biology of the cancer (rapid tumor growth) than by diagnostic delay.

Cited by 31 publications

References 34 publications

Trends in incidence, tumour sites and tumour stages of oral and pharyngeal cancer in Northern Germany

Trends in incidence, tumour sites and tumour stages of oral and pharyngeal cancer in Northern Germany

Factors related to late stage diagnosis of oral squamous cell carcinoma

GLIMMPSE: Online Power Computation for Linear Models with and without a Baseline Covariate

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